中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2013
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Article Contents

Targeted therapy of liver fibrosis on the horizon

DOI: 10.3969/j.issn.1001-5256.2013.11.004
  • Received Date: 2013-07-30
  • Published Date: 2013-11-20
  • Over the past few years, significant advances have occurred in the targeted therapy of liver fibrosis. However, it is still a big challenge to deliver drugs to target cells and exert desirable therapeutic effect. The research on targeted therapy of liver fibrosis, including the types of target cells and target molecules and their selection rules, the general rules and methods for carrier selection and modification, and the evaluation of treatment outcomes and toxic or side effects, is reviewed. It is pointed out that liver fibrosis is a complex pathological process involving multiple cells, cytokines, and signaling pathways, so selecting suitable therapeutic target is the key to targeted therapy, and proper development of targeted delivery system is the guarantee for successful treatment.

     

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