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Volume 40 Issue 4
Apr.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(4): 822-827

Role of the Hedgehog signaling pathway in hepatocellular carcinoma and its tumor microenvironment

DOI: 10.12449/JCH240429
  • 1.

    Department of Integrated Traditional Chinese and Western Medicine，Beijing Ditan Hospital，Capital Medical University，Beijing 100102，China

  • 2.

    Department of Infectious Diseases，Shanxi Bethune Hospital，Taiyuan 030021，China

Research funding:

State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project of Traditional Chinese Medicine (zyyzdxk-2023005);

Capital Health Development Research Project (2024-1-2173)

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  • Corresponding author: WANG Xianbo， wangxb@ccmu.edu.cn （ORCID： 0000-0002-3593-5741）
  • Received Date: 2023-06-28
  • Accepted Date: 2023-10-07
  • Published Date: 2024-04-11
    Abstract
  • The Hedgehog （Hh） signaling pathway plays an important role in the development and progression of hepatocellular carcinoma and its tumor microenvironment， and abnormal activation of Hh signal can accelerate the growth of tumor. The crosstalk between the Hh signaling pathway and TME is closely associated with tumor growth and the formation of inhibitory tumor microenvironment. Evidence shows that inhibition of Hh signal plays an important role in inhibiting the growth of hepatocellular carcinoma. This article reviews the current research status of the role， mechanism， and potential therapeutic significance of abnormal activation of Hh signal in hepatocellular carcinoma and its tumor microenvironment， so as to provide new ideas for the treatment of hepatocellular carcinoma.

     

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