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Volume 40 Issue 4
Apr.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(4): 810-815

Mechanism of amino acid metabolism in nonalcoholic fatty liver disease

DOI: 10.12449/JCH240427

  • Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education，Chongqing Medical University，Chongqing 010000，China

Research funding:

General Project of National Natural Science Foundation of China (82273423);

Youth Fund of National Natural Science Foundation of China (82202501)

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  • Corresponding author: CHEN Juan， chenjuan2014@cqmu.edu.cn （ORCID： 0000-0001-6920-7972）
  • Received Date: 2023-08-01
  • Accepted Date: 2023-10-07
  • Published Date: 2024-04-11
    Abstract
  • Nonalcoholic fatty liver disease （NAFLD） is one of the most prevalent chronic liver diseases in the world， affecting about one quarter of the global population， and it is estimated that NAFLD will become the main indication for liver transplantation by 2030. NAFLD can lead to significant abnormalities in the levels of a variety of amino acids including branched-chain amino acids， thereby promoting the development and progression of NAFLD. These results suggest that in addition to glucose and lipid metabolism， amino acid metabolism also plays an important role in the progression of NAFLD. In order to systematically understand the role and mechanism of amino acid metabolism in NAFLD， this article reviews the research advances in amino acid metabolism in NAFLD. This article aims to explore the role and mechanism of amino acid metabolism in the progression of NAFLD， so as to provide ideas and a theoretical basis for clinical prevention and treatment.

     

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