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Volume 40 Issue 2
Feb.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(2): 233-238

Research advances in combined artificial liver

DOI: 10.12449/JCH240203

  • Department of Infectious Diseases，Guizhou Provincial People’s Hospital，Guizhou 550000，China

Research funding:

Guizhou Science and Technology Foundation (ZK［2021］Key 013)

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  • Corresponding author: LUO Xinhua， luoxinhua1972@126.com （ORCID： 0000-0001-8285-3063）
  • Received Date: 2023-10-30
  • Accepted Date: 2023-11-29
  • Published Date: 2024-02-19
    Abstract
  • At present， in vitro artificial liver support system has achieved a good therapeutic effect in the diseases such as liver failure due to various causes， non-function state before and after liver transplantation， and severe cholestasis. Non-bioartificial liver （NBAL） is widely used in clinical practice through various combinations of modes， mainly the plasma exchange mode for improving coagulation factors and albumin combined with other modes for enhancing the elimination of toxic substances in the body. Bioartificial liver （BAL）， based on the design concept of the synthesis and transformation of hepatocytes， has achieved rapid development in recent years. Patients with liver failure can almost obtain the normal physiological function of human liver after NBAL detoxification and BAL synthesis and transformation of active substances in the body. NBAL mode combined with BAL with a stable therapeutic effect according to the conditions of the patient is the direction of in vitro support treatment for patients with severe liver disease in the future.

     

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