HIV感染合并自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征1例报告
DOI: 10.3969/j.issn.1001-5256.2023.09.021
伦理声明:本例报告已获得患者知情同意。
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:彭世秀、黄爱萍负责课题设计,资料分析,撰写论文;朱松涛、麦静、伍丽萍参与收集资料;李春燕负责修改论文并最后定稿。
Human immunodeficiency virus infection comorbid with autoimmune hepatitis-primary biliary cholangitis overlap syndrome: A case report
-
摘要: 获得性免疫缺陷综合征(AIDS)主要侵犯人体的免疫系统,最终导致人体细胞免疫功能严重缺陷。自身免疫性肝炎(AIH)-原发性胆汁性胆管炎(PBC)重叠综合征是由于自身免疫功能紊乱引起肝细胞及毛细胆管损伤,在自身免疫性肝病重叠综合征类型中较为常见,而AIH-PBC重叠综合征合并HIV感染较为罕见。广汉市人民医院联合西部战区总医院报道1例HIV感染合并AIH-PBC重叠综合征患者的诊治,为该类疾病临床诊治提供借鉴。Abstract: Acquired immunodeficiency syndrome mainly invades the human immune system and eventually leads to serious defects in human cellular immune function. Autoimmune hepatitis (AIH)-primary biliary cholangitis (PBC) overlap syndrome is a common type of the overlap syndrome of autoimmune liver disease and involves the damage to liver cells and bile capillaries caused by autoimmune dysfunction, while AIH-PBC overlap syndrome comorbid with human immunodeficiency virus (HIV) infection is relatively rare. Guanghan People’s Hospital, in collaboration with The General Hospital of Western Theater Command, reported the diagnosis and treatment of a patient with HIV infection and AIH-PBC overlap syndrome, so as to provide a reference for the clinical diagnosis and treatment of this type of disease.
-
Key words:
- HIV Infections /
- Hepatitis, Autoimmune /
- Primary Biliary Cholangitis
-
[1] Acquired Immunodeficiency Syndrome and Hepatitis C Professional Group, Society of Infectious Diseases, Chinese Medical Association; Chinese Center for Disease Control and Prevention. Chinese guidelines for diagnosis and treatment of human immunodeficiency virus infection/acquired immunodeficiency syndrome(2021 edition)[J]. Med J Peking Union Med Coll Hosp, 2022, 13( 2): 203- 226. DOI: 10.12290/xhyxzz.2022-0097.中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心. 中国艾滋病诊疗指南(2021年版)[J]. 协和医学杂志, 2022, 13( 2): 203- 226. DOI: 10.12290/xhyxzz.2022-0097. [2] WU MC, LI MD. Practice of hepatology[M]. Beijing: People’s Medical Publishing House, 2011: 228.吴孟超, 李梦东. 实用肝脏病学[M]. 北京: 人民卫生出版社, 2011: 228. [3] RUST C, BEUERS U. Overlap syndromes among autoimmune liver diseases[J]. World J Gastroenterol, 2008, 14( 21): 3368- 3373. DOI: 10.3748/wjg.14.3368. [4] XIE J, LI TS. Research progress on abnormal immune activation associated with human immunodeficiency virus infection[J]. Natl Med J China, 2014( 31): 2477- 2479. DOI: 10.3760/cma.j.issn.0376-2491.2014.31.022.谢静, 李太生. 人类免疫缺陷病毒感染相关异常免疫激活研究进展[J]. 中华医学杂志, 2014( 31): 2477- 2479. DOI: 10.3760/cma.j.issn.0376-2491.2014.31.022. [5] YAO DK, PENG Y. Current status and prospects of diagnosis and treatment of autoimmune liver diseases[J]. J Southwest Med Univ, 2022, 45( 1): 26- 28, 43. DOI: 10.3969/j.issn.2096-3351.2022.01.006.姚定康, 彭宇. 常见自身免疫性肝病的诊治现状与展望[J]. 西南医科大学学报, 2022, 45( 1): 26- 28, 43. DOI: 10.3969/j.issn.2096-3351.2022.01.006. [6] Chinese Society of Hepatology, Chinese Medical Association. Guidelines on the diagnosis and management of autoimmune hepatitis(2021)[J]. J Clin Hepatol, 2022, 38( 1): 42- 49.中华医学会肝病学分会. 自身免疫性肝炎诊断和治疗指南(2021)[J]. 临床肝胆病杂志, 2022, 38( 1): 42- 49. [7] CHAZOUILLÈRES O, WENDUM D, SERFATY L, et al. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy[J]. Hepatology, 1998, 28( 2): 296- 301. DOI: 10.1002/hep.510280203. [8] CHEN L, YOU J. Research advances in pathogenesis of HIV infection and acquired immunodeficiency syndrome[J]. Med Recapitulate, 2010, 16( 24): 3713- 3716. DOI: 10.3969/j.issn.1006-2084.2010.24.012.陈丽, 游晶. HIV/AIDS发病机制的研究进展[J]. 医学综述, 2010, 16( 24): 3713- 3716. DOI: 10.3969/j.issn.1006-2084.2010.24.012. [9] CHAITEERAKIJ R, SANPAWAT A, AVIHINGSANON A, et al. Autoimmune hepatitis in human immunodeficiency virus-infected patients: A case series and review of the literature[J]. World J Gastroenterol, 2019, 25( 35): 5388- 5402. DOI: 10.3748/wjg.v25.i35.5388. [10] O’LEARY JG, ZACHARY K, MISDRAJI J, et al. De novo autoimmune hepatitis during immune reconstitution in an HIV-infected patient receiving highly active antiretroviral therapy[J]. Clin Infect Dis, 2008, 46( 1): e12-e14. DOI: 10.1086/524082. [11] HU ML, WANG QX, MA X. Advances in the pathogenesis of autoimmune hepatitis and new targets for clinical intervention[J]. J Clin Hepatol, 2022, 38( 4): 743- 747. DOI: 10.3969/j.issn.1001-5256.2022.04.002.胡明礼, 王绮夏, 马雄. 自身免疫性肝炎发病机制进展与临床干预新靶点[J]. 临床肝胆病杂志, 2022, 38( 4): 743- 747. DOI: 10.3969/j.issn.1001-5256.2022.04.002.