脾切除术对肝硬化病程的影响及机制

郑政隆; 徐先鹏; 李白雪; 苏悦; 谢伊兰; 冯全生

doi:10.3969/j.issn.1001-5256.2023.08.029

脾切除术对肝硬化病程的影响及机制

DOI: 10.3969/j.issn.1001-5256.2023.08.029

郑政隆^{1, 2},
徐先鹏¹,
李白雪¹,
苏悦¹,
谢伊兰³,
冯全生^1, , ,

1.
成都中医药大学，成都 610075
2.
简阳市中医医院消化内科，成都 610075
3.
简阳市人民医院全科医学科，成都 610075

基金项目:

四川省科技计划重点研发项目 (2020YFS0301)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：郑政隆负责课题设计，资料分析，撰写论文；徐先鹏、谢伊兰参与收集数据，资料查询；李白雪、苏悦参与修改论文；冯全生负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
冯全生，fengqs118@163.com (ORCID: 0000-0003-3437-8987)

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- 被引次数: 0
出版历程
- 收稿日期: 2022-11-22
- 录用日期: 2023-01-20
- 出版日期: 2023-08-20

Influence of splenectomy on the course of liver cirrhosis and related mechanism

1.
Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
2.
Department of Digestive Medicine, Jianyang Hospital of Traditional Chinese Medicine, Chengdu 610075, China
3.
Department of General Medicine, Jianyang People's Hospital, Chengdu 610075, China

Research funding:

Key Technology Research and Development Program of Sichuan Province (2020YFS0301)

More Information

Corresponding author: FENG Quansheng, fengqs118@163.com (ORCID: 0000-0003-3437-8987)

摘要

摘要: 脾肿大是肝硬化门静脉高压常见的病理改变，并可进展为脾功能亢进，导致患者血细胞减少，增加临床出血、感染等风险。脾切除术是治疗脾大伴脾功能亢进的重要手段，但面临着感染、手术出血、术后血栓形成、术后胰瘘等风险。然而，随着现代研究的不断深入，脾切除术后肝硬化患者的病情在一定程度上得到了改善，例如降低消化道出血的风险、降低门静脉的压力、改善内脏等的血流动力学、促进肝组织的再生、改善肝纤维化、调节免疫、改善营养状况、降低肝癌发生的风险等。本文结合现有的临床和实验研究，综述了脾切除术对肝硬化病程的影响及其机制，以期为临床脾切除术的选择和开展提供可靠的参照和依据。
- 肝硬化 /
- 脾切除术 /
- 脾功能亢进
Abstract: Splenomegaly is a common pathological change of portal hypertension in liver cirrhosis and can progress to hypersplenism, leading to the reduction in blood cells and increasing the risk of clinical bleeding and infection. Splenectomy is an important method for the treatment of splenectomy with hypersplenism, but it faces the risks of infection, surgical bleeding, postoperative thrombosis, and postoperative pancreatic fistula. However, with the gradual deepening of modern research, it has been found that patients with liver cirrhosis have a certain degree of improvement after splenectomy, such as the reduced risk of gastrointestinal bleeding, a reduction in portal venous pressure, the improvement in the hemodynamics of internal organs, the promotion of liver tissue regeneration, the improvement in liver fibrosis, the regulation of immune function, the improvement in nutritional status, and the reduced risk of liver cancer. With reference to available clinical and experimental studies, this article reviews the influence of splenectomy on the course of liver cirrhosis and actively explores related mechanism, in order to provide reliable reference and basis for the selection and implementation of splenectomy in clinical practice.
- Liver Cirrhosis /
- Splenectomy /
- Hypersplenism

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参考文献(50)

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