肠道菌群及其代谢产物在非酒精性脂肪性肝病发生发展及治疗中的作用
DOI: 10.3969/j.issn.1001-5256.2023.08.006
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:李永强负责论文的拟定及撰写; 唐文娟负责论文的修改; 周永健参与修改论文并最后定稿。
Role of intestinal microbiota and metabolites in the development, progression, and treatment of nonalcoholic fatty liver disease
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摘要: 非酒精性脂肪性肝病(NAFLD)是全世界最为常见的慢性肝病。肝脏与肠道之间有着紧密的结构及功能关系即“肠-肝轴”,其中肠道菌群可通过菌群易位、内源性乙醇的产生、胆汁酸和胆碱代谢的调节异常、内毒素血症等参与NAFLD的发生、发展。本文主要关注肠道菌群及代谢产物在NAFLD发生、发展及治疗中的作用进展。Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease around the world. There is a close structural and functional relationship between the liver and the intestine, namely "the gut-liver axis", in which intestinal microbiota can participate in the development and progression of NAFLD through microbial translocation, production of endogenous ethanol, abnormal regulation of bile acid metabolism and choline metabolism, and endotoxemia. This article reviews the role of intestinal microbiota and metabolites in the development, progression, and treatment of NAFLD.
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