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肝癌微环境中肿瘤相关巨噬细胞的研究进展
DOI: 10.3969/j.issn.1001-5256.2023.05.033
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：汪鹏、仇建南负责收集数据，资料分析，撰写论文；王忠夏负责修改文章；江春平、吴俊华提供写作思路，指导撰写文章，修改文章并最后定稿。
Research advances in tumor-associated macrophages in hepatocellular carcinoma microenvironment
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摘要: 由于肝细胞癌早期临床症状不明显，患者确诊时大多已发展到晚期阶段。错失最佳手术机会的肝癌患者治疗手段有限，因此寻找新的治疗靶点变得十分重要。肿瘤相关巨噬细胞(TAM)，是存在于肿瘤免疫微环境中一群巨噬细胞，影响着肝癌细胞的各种恶性行为和肿瘤内的免疫逃逸状态。介绍了TAM的起源和分类，归纳了TAM在肝癌血管增生、侵袭转移、干细胞特性的形成和维持、以及抗肿瘤免疫中的作用和机制，简述了当前针对TAM的治疗靶点的研究进展等，认为靶向TAM可能是一个有前景的临床治疗方向。Abstract: Since there is a lack of obvious clinical symptoms in the early stage of hepatocellular carcinoma (HCC), most patients have progressed to the advanced stage at the time of confirmed diagnosis. There are limited treatment options for HCC patients who miss the opportunity for surgery, so it is of great importance to find new therapeutic targets. Tumor-associated macrophages (TAMs) are a group of macrophages existing in the tumor immune microenvironment and affect the malignant behaviors of HCC cells and the state of immune escape within the tumor. This article introduces the origin and classification of TAM, summarizes the role and mechanism of TAMs in vascular proliferation, invasion and metastasis, formation and maintenance of stemness, and anti-tumor immunity in HCC, and briefly describes the current research advances in therapeutic targets for TAM, and it is pointed out that targeting TAM may be a promising direction for clinical treatment.
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