中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

急性乙型肝炎合并一过性再生障碍性贫血1例报告

张玉 田雨 董美丽 张瑞华 王阳 温晓玉

引用本文:
Citation:

急性乙型肝炎合并一过性再生障碍性贫血1例报告

DOI: 10.3969/j.issn.1001-5256.2023.03.021
基金项目: 

吉林省科技计划项目基金 (20190201065JC)

伦理学声明:本例报告已获得患者知情同意。
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张玉负责资料分析,撰写论文;田雨、董美丽、张瑞华参与收集并分析数据;王阳负责撰写文章并修改文章;温晓玉指导撰写文章并最后定稿。
详细信息
    通信作者:

    温晓玉,xywen@jlu.edu.cn(ORCID: 0000-0003-2109-1557)

Transient aplastic anemia associated with acute hepatitis B: A case report

Research funding: 

Foundation of Science and Technology Commission of Jilin Province (20190201065JC)

More Information
    Corresponding author: WEN Xiaoyu, xywen@jlu.edu.cn (ORCID: 0000-0003-2109-1557)
  • 图  1  住院期间WBC、RBC、PLT和Hb变化

    Figure  1.  Time course of WBC、RBC、PLT and Hb while in hospital

    图  2  住院期间骨髓穿刺涂片(×1000)

    注:a、b,髂骨骨髓增生重度降低,粒细胞缺乏,巨核细胞少,吞噬细胞易见;c、d,胸骨骨髓增生活跃,粒、红两系比例大致正常,粒细胞颗粒明显增多,血小板成堆可见。

    Figure  2.  Bone marrow aspirate smear while in hospital(×1000)

    表  1  住院期间HBV血清标志物及HBV DNA变化

    Table  1.   Time course of serum markers of HBV and HBV DNA while in hospital

    时间 HBsAg
    (IU/mL)
    抗-HBs
    (mIU/mL)
    HBeAg
    (COI)
    抗-HBe
    (COI)
    抗-HBc
    (COI)
    HBV DNA
    (IU/mL)
    2021.10.13 <0.050 23.14 0.121 0.01 0.01 151
    2021.10.24 0 - - - - 197
    2021.11.01 0 - - - - 53
    2021.11.10 0 244.58 0.391 0.400 5.490 <50
    下载: 导出CSV
  • [1] KILLICK SB, BOWN N, CAVENAGH J, et al. Guidelines for the diagnosis and management of adult aplastic anaemia[J]. Br J Haematol, 2016, 172(2): 187-207. DOI: 10.1111/bjh.13853.
    [2] WANG L, LIU H. Pathogenesis of aplastic anemia[J]. Hematology, 2019, 24(1): 559-566. DOI: 10.1080/16078454.2019.1642548.
    [3] BROWN KE, TISDALE J, BARRETT AJ, et al. Hepatitis-associated aplastic anemia[J]. N Engl J Med, 1997, 336(15): 1059-1064. DOI: 10.1056/NEJM199704103361504.
    [4] MORI T, ONISHI Y, OZAWA Y, et al. Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia[J]. Int J Hematol, 2019, 109(6): 711-717. DOI: 10.1007/s12185-019-02644-8.
    [5] ZAHNG YT, YE D, LI XY, et al. Baseline HBsAg quantitative level, dynamic changes and clinical signifi-cance of adult acute hepatitis B[J]. China Mod Doct, 2021, 59(12): 1-4, 15, 193. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202112001.htm

    张雨婷, 叶栋, 李欣予, 等. 成人急性乙型肝炎基线HBsAg定量水平、动态变化及临床意义[J]. 中国现代医生, 2021, 59(12): 1-4, 15, 193. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202112001.htm
    [6] Red Cell Disease (Anemia) Group, Hematology Branch, Chinese Medical Association. Chinese expert consensus on the diagnosis and treatment of aplastic anemia (2017)[J]. Chin J Hematol, 2017, 38(1): 1-5. DOI: 10.3760/cma.j.issn.0253-2727.2017.01.001.

    中华医学会血液学分会红细胞疾病(贫血)学组. 再生障碍性贫血诊断与治疗中国专家共识(2017年版)[J]. 中华血液学杂志, 2017, 38(1): 1-5. DOI: 10.3760/cma.j.issn.0253-2727.2017.01.001.
    [7] HENDREN N, MOORE J, HOFMANN S, et al. Resolution of acute hepatitis B-associated aplastic anaemia with antiviral therapy[J]. BMJ Case Rep, 2017, 2017: bcr2017221503. DOI: 10.1136/bcr-2017-221503.
    [8] BOZKAYA H, YURDAYDIN C, TÖRVNER M, et al. Remission of severe aplastic anemia associated with hepatitis B virus infection after viral clearance: potential role of lamivudine[J]. Dig Dis Sci, 2002, 47(8): 1782-1785. DOI: 10.1023/a:1016444611997.
    [9] IKEDA T, MORIMOTO A, NAKAMURA S, et al. A marked decrease in CD4-positive lymphocytes at the onset of hepatitis in a patient with hepatitis-associated aplastic anemia[J]. J Pediatr Hematol Oncol, 2012, 34(5): 375-377. DOI: 10.1097/MPH.0b013e31822bf699.
    [10] AKRAM Z, AHMED P, KAJIGAYA S, et al. Epidemiological, clinical and genetic characterization of aplastic anemia patients in Pakistan[J]. Ann Hematol, 2019, 98(2): 301-312. DOI: 10.1007/s00277-018-3542-z.
    [11] BÄR C, POVEDANO JM, SERRANO R, et al. Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia[J]. Blood, 2016, 127(14): 1770-1779. DOI: 10.1182/blood-2015-08-667485.
    [12] SHI YM, LAN YH, SHAN L, et al. The relationship between of hematopoietic stem cells and hepatitis B virus infection[J]. J Clin Hepatol, 2010, 26(4): 377-380. DOI: 10.3969/j.issn.1001-5256.2010.04.012.

    石雁梅, 兰英华, 单蕾, 等. 乙型肝炎病毒感染时的骨髓造血干细胞[J]. 临床肝胆病杂志, 2010, 26(4): 377-380. DOI: 10.3969/j.issn.1001-5256.2010.04.012.
    [13] RULE JA, HYNAN LS, ATTAR N, et al. Procalcitonin identifies cell injury, not bacterial infection, in acute liver failure[J]. PLoS One, 2015, 10(9): e0138566. DOI: 10.1371/journal.pone.0138566.
    [14] ZHANG Q, RAOOF M, CHEN Y, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury[J]. Nature, 2010, 464(7285): 104-107. DOI: 10.1038/nature08780.
    [15] ROH JS, SOHN DH. Damage-associated molecular patterns in inflammatory diseases[J]. Immune Netw, 2018, 18(4): e27. DOI: 10.4110/in.2018.18.e27.
    [16] MATWIYOFF GN, PRAHL JD, MILLER RJ, et al. Immune regulation of procalcitonin: a biomarker and mediator of infection[J]. Inflamm Res, 2012, 61(5): 401-409. DOI: 10.1007/s00011-012-0439-5.
    [17] LAI ZX, WANG F, WANG S, et al. Acute-on-chronic liver failure with severe bone marrow suppression: A case report[J]. J Clin Hepatol, 2019, 35(9): 2050-2053. DOI: 10.3969/j.issn.1001-5256.2019.09.034.

    赖长祥, 王方, 王松, 等. 慢加急性肝衰竭合并严重骨髓抑制1例报告[J]. 临床肝胆病杂志, 2019, 35(9): 2050-2053. DOI: 10.3969/j.issn.1001-5256.2019.09.034.
  • 加载中
图(2) / 表(1)
计量
  • 文章访问数:  309
  • HTML全文浏览量:  121
  • PDF下载量:  97
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-08-03
  • 录用日期:  2022-09-20
  • 出版日期:  2023-03-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回