中药抗肝纤维化实验研究进展

尚小飞; 李秀惠

doi:10.3969/j.issn.1001-5256.2023.02.001

中药抗肝纤维化实验研究进展

DOI: 10.3969/j.issn.1001-5256.2023.02.001

尚小飞^{1, 2},
李秀惠^1, , ,

1.
首都医科大学附属北京佑安医院中西医结合中心，北京 100069
2.
北京市肝病研究所，北京 100069

基金项目:

中国博士后科学基金 (2021M702312);

北京市博士后工作基金 (2021-ZZ-049)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：尚小飞参与起草文章，组织语言，整理参考文献等；李秀惠提出文章思路，并对文章进行修改。

详细信息

通信作者:
李秀惠，lixiuhui@sohu.com (ORCID: 0000-0002-6707-1693)

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出版历程
- 收稿日期: 2022-12-10
- 录用日期: 2023-01-14
- 出版日期: 2023-02-20

Advances in the experimental research on traditional Chinese medicine against liver fibrosis

Xiaofei SHANG^{1, 2},
Xiuhui LI^{1
, ,
,}

1.
Integrated Chinese and Western Medicine Center, Beijing YouAn Hospital of Capital Medical University, Beijing 100069, China
2.
Beijing Institute of Hepatology, Beijing 100069, China

Research funding:

China Postdoctoral Science Foundation (2021M702312);

Beijing Postdoctoral Research Foundation (2021-ZZ-049)

More Information

Corresponding author: LI Xiuhui, lixiuhui@sohu.com (ORCID: 0000-0002-6707-1693)

摘要

摘要: 肝纤维化是由病毒性肝炎、酒精中毒等多种病因导致的慢性肝脏疾病的共同病理过程，可进展为肝硬化，乃至肝癌，严重威胁人类健康。中药在抑制肝纤维化进展和促进肝纤维化逆转方面有着“多成分-多靶点-多途径”的作用特点，具备独特的临床疗效。近年来，中药抗肝纤维化的实验研究取得了较大的进展，许多具有良好抗肝纤维化作用的中药复方和单味药及其有效成分被发现，并从细胞、分子水平等方面揭示了其潜在的作用机制。为进一步阐明中药抗肝纤维化实验研究进展，本文从中药抗肝纤维化实验动物模型、中药抗肝纤维化作用机理、从动物实验到临床试验的中药研究三方面，系统阐述了其近5年的研究进展，为科研人员及临床医师开展中药抗肝纤维化药物研发和应用提供参考。
- 肝纤维化 /
- 中药 /
- 动物模型 /
- 作用机理 /
- 进展
Abstract: Liver fibrosis is the common pathological process of chronic liver diseases caused by various etiologies such as viral hepatitis and alcoholism, and it can progress to liver cirrhosis and even liver cancer and seriously threatens human health. Traditional Chinese medicine (TCM) has the characteristics of multiple components, targets, and pathways in inhibiting the progression of liver fibrosis and promoting the reversal of liver fibrosis and thus has unique clinical efficacy. In recent years, great progress has been made in the experimental research on the anti-liver fibrosis potential of TCM, and related studies have found a variety of compound TCM prescriptions, single TCM medicine, and their effective constituents and revealed their potential mechanism of action from the cellular and molecular levels. In order to further clarify the advances in the experimental research on the anti-liver fibrosis potential of TCM, this article systematically reviews the research advances in the past five years from the aspects of experimental animal models for the anti-liver fibrosis potential of TCM, the mechanism of action of TCM in the treatment of liver fibrosis, and TCM research from animal experiments to clinical trials, so as to provide a reference for researchers and clinicians to develop and apply anti-liver fibrosis TCM drugs.
- Liver Fibrosis /
- Traditional Chinese Medicine /
- Animal Model /
- Mechanism /
- Progress

HTML全文

表 1 肝毒素、非酒精性脂肪肝炎和胆道纤维化的肝纤维化模型诱导方法及特点^[8]

Table 1. Induction methods and characteristics of hepatic fibrosis models of hepatotoxin, nonalcoholic steatohepatitis and biliary fibrosis^[8]

项目	肝毒素导致的肝纤维化	非酒精性脂肪性肝炎肝纤维化	胆道纤维化
常用诱导方法	CCl₄^、TAA^、DMN/DEN、酒精等	饮食：HFHCD^、MCD^ 饮食+遗传修饰：foz/foz或db/db 小鼠+高脂饮食等	手术：BDL^* 饮食：DDC、CDE、ANIT 遗传修饰：Mdr2等
造模时长	CCl₄：6~12周 TAA：8~24周	HFHCD：＞24周 MCD: ＞12周	BDL: 2~3周 Mdr2：＞6周龄
主要病理特点	间隔纤维化	网眼状纤维化	门静脉纤维化洋葱皮样纤维化
注：代表最为常用的诱导方法。CCl₄，四氯化碳；TAA，硫代乙酰胺；HFHCD，高脂高胆固醇饮食；MCD，蛋氨酸和胆碱缺乏饮食；BDL，胆管结扎术；CDE，缺乏胆碱的乙硫氨酸补充饮食；ANIT，α-异硫氰酸萘酯饮食；Mdr*2，多药耐药相关蛋白2基因；DMN/DEN，二甲基亚硝胺和二乙基亚硝胺。

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