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邻苯二甲酸酯对胆汁淤积性肝病影响的研究进展

张佳怡 王建青

引用本文:
Citation:

邻苯二甲酸酯对胆汁淤积性肝病影响的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.01.035
基金项目: 

国家自然科学基金 (82073566)

安徽省高校优秀青年人才支持计划资助项目 (gxyq2019014)

临床药学与药理学共建项目 (2020)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张佳怡负责查阅文章,撰写论文; 王建青负责修改文章并最后定稿。
详细信息
    通信作者:

    王建青,jianqingwang81@126.com (ORCID: 0000-0002-7935-9520)

Research advances in the impact of phthalates on cholestatic liver disease

Research funding: 

National Natural Science Foundation of China (82073566);

the Program of Excellent Young Talents in Universities of Anhui Province (gxyq2019014);

Co-sponsored by Clinical Pharmacy and Pharmacology (2020)

More Information
  • 摘要: 胆汁淤积性肝病是由于胆汁生成、排泄及代谢障碍,造成胆汁在肝脏沉积所致的一类常见肝胆疾病。目前胆汁淤积性肝病的致病因素尚未充分阐明,但有研究者认为环境因素可能在其中发挥重要作用。环境污染物邻苯二甲酸酯已被证实可干扰人类内分泌系统,对人体具有潜在毒性,危及肝肾功能,且可能增加肝内胆汁淤积的发生风险。基于此,本研究对邻苯二甲酸酯与胆汁淤积性肝病的关系进行综述,分别从临床研究、动物实验研究和体外实验研究及潜在机制进行总结,为胆汁淤积性肝病的预防以及临床治疗提供思路和参考。

     

  • 图  1  胆汁酸转运示意图

    注:BA,胆汁酸;FXR,法尼醇受体;SHP,小异二聚体伴侣;CYP7A1,胆固醇7α-羟化酶;BSEP,胆盐输出泵;MRP2,胆盐输出泵;IBAT,回肠胆汁酸转运体;FGF19,成纤维细胞生长因子19;OATP,有机阴离子转运肽;NTCP,Na+-牛磺酸共转运多肽。

    Figure  1.  Bile acid transport

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  • 收稿日期:  2022-05-02
  • 录用日期:  2022-07-25
  • 出版日期:  2023-01-20
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