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细胞器之间相互作用在非酒精性脂肪性肝病发生发展中的作用

刘天会

引用本文:
Citation:

细胞器之间相互作用在非酒精性脂肪性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2023.01.028
基金项目: 

国家自然科学基金面上项目 (82070618)

利益冲突声明:作者声明不存在利益冲突。
详细信息
    通信作者:

    刘天会, liu_tianhui@163.com (ORCID: 0000-0001-6789-3016)

Role of organelle interaction in the development and progression of nonalcoholic fatty liver disease

Research funding: 

National Natural Science Foundation of China (82070618)

More Information
  • 摘要: 细胞器除了具有各自特定的功能外,还可与其他细胞器相互作用完成重要的生理功能。细胞器之间相互作用的异常与疾病的发生发展密切相关。近年来,细胞器之间相互作用在非酒精性脂肪性肝病(NAFLD)发生发展中的作用受到关注,特别是线粒体、脂滴与其他细胞器之间的相互作用。

     

  • 图  1  线粒体与其他细胞器之间的相互作用

    注:FFA,游离脂肪酸;IP3R,三磷酸肌醇受体;VDAC,电压依赖性阴离子选择性通道蛋白;GRP75,葡萄糖调节蛋白75;IFN2,肌动蛋白成核因子2;Spire1C,与甲酸结合的肌动蛋白成核蛋白1C;Mfn2,线粒体融合蛋白2;Plin1,脂滴包被蛋白1;Plin5,脂滴包被蛋白5;ECI2,烯酰辅酶A异构酶2;TOM20,线粒体外膜转位酶20;RAB7,Ras相关GTP结合蛋白7。图中使用的线粒体及高尔基体模式图来自BioRender网站。

    Figure  1.  Interactions between mitochondria and other organelles

    图  2  脂滴与其他细胞器之间的相互作用

    注:UBXD8,泛素调节X结构域蛋白8;TGN,高尔基体反面囊膜;VPS13B,液泡蛋白分选相关蛋白13B;DGAT2,二酰甘油酰基转移酶2;CCTα,磷酸胆碱胞苷酰转移酶α;ATGL,脂肪甘油三酯脂肪酶。图中使用的细胞核及高尔基体模式图来自BioRender网站。

    Figure  2.  Interactions between lipid droplets and other organelles

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  • 收稿日期:  2022-07-30
  • 录用日期:  2022-08-31
  • 出版日期:  2023-01-20
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