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扩大慢性乙型肝炎初始治疗:降低ALT治疗阈值

张佳怡 陈姝延 尤红

引用本文:
Citation:

扩大慢性乙型肝炎初始治疗:降低ALT治疗阈值

DOI: 10.3969/j.issn.1001-5256.2023.01.004
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张佳怡负责撰写论文;陈姝延负责修改论文;尤红负责指导、审阅论文。
详细信息
    通信作者:

    尤红,youhong30@sina.com (ORCID: 0000-0001-9409-1158)

Expanding initial anti-HBV therapy for chronic hepatitis B: Reducing the treatment threshold of alanine aminotransferase

More Information
  • 摘要: 为实现世界卫生组织制定的2030年全球消除病毒性肝炎公共卫生危害的目标,扩大慢性乙型肝炎的治疗人群尤为重要。近些年,各种研究表明,ALT与肝脏炎症、纤维化、肝细胞癌和肝病终点事件均有关。降低ALT治疗阈值作为扩大抗病毒治疗的策略,可减少肝硬化、肝细胞癌及肝病相关死亡事件的发生。在2022年我国《扩大慢性乙型肝炎抗病毒治疗的专家意见》中,对于慢性乙型肝炎患者的治疗适应证已更新为血清HBV DNA阳性,ALT高于治疗阈值(男性30 U/L,女性19 U/L),且排除其他原因。

     

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  • 收稿日期:  2022-11-18
  • 出版日期:  2023-01-20
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