沉默调节蛋白1在酒精性肝病中的作用机制及相关药物研究进展

刘甜恬; 刘江凯; 李素领; 刘靓; 张雅儒; 张建文; 李冰倩

doi:10.3969/j.issn.1001-5256.2022.12.030

沉默调节蛋白1在酒精性肝病中的作用机制及相关药物研究进展

DOI: 10.3969/j.issn.1001-5256.2022.12.030

1.
河南中医药大学第一临床医学院，郑州 450018
2.
河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

国家自然科学基金(联合基金) (U1504825);

河南省高等学校重点科研项目 (20A360014);

河南省中医药拔尖人才培养项目资助 (Yuwei Traditional Chinese Medicine 2021 No.15)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：刘甜恬负责课题设计，资料分析，撰写论文；李素领负责修改论文；刘靓、张雅儒、张建文、李冰倩参与收集及分析文献资料；刘江凯负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
刘江凯，xmlc001@126.com

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出版历程
- 收稿日期: 2022-05-07
- 录用日期: 2022-06-17
- 出版日期: 2022-12-20

Advances in the mechanism of action of silent information regulator 1 in alcoholic liver disease and related pharmaceutical studies

1.
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450018, China
2.
Spleen, Stomach and Hepatobiliary Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (Joint Fund) (U1504825);

Key Scientific Research Projects of Colleges and Universities in Henan Province (20A360014);

Henan Provincial Top talents training Program of Traditional Chinese Medicine (Yuwei Traditional Chinese Medicine 2021 No.15)

More Information

Corresponding author: LIU Jiangkai, xmlc001@126.com (ORCID: 0000-0002-1529-5089)

摘要

摘要: 酒精性肝病(ALD)是全球慢性肝病的主要病种之一，我国ALD发病率正逐年上升且呈年轻化发展态势。沉默调节蛋白1(SIRT1)是一种烟酰胺腺嘌呤二核苷酸依赖性的脱乙酰化酶，在细胞代谢、氧化应激、炎症反应等方面作用显著，有望成为ALD治疗新靶点。本文总结了SIRT1在ALD中的作用机制及相关药物研究，以期为进一步研究ALD发病机制及其潜在治疗靶标提供参考和策略。
- 酒精性肝病 /
- 沉默信息调节蛋白质类 /
- 炎症
Abstract: Alcoholic liver disease (ALD) is one of the main chronic liver diseases in the world, and the prevalence rate of ALD is increasing year by year in China, with a trend of earlier age of onset. Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase and plays a significant role in cell metabolism, oxidative stress, and inflammation, and it is expected to become a new therapeutic target for ALD. This article reviews the mechanism of action of SIRT1 in ALD and related pharmaceutical studies, in order to provide a reference and strategies for further research on the pathogenesis of ALD and its potential therapeutic targets.
- Alcoholic Liver Disease /
- Silent Information Regulator Proteins /
- Inflammation

HTML全文

图 1 SIRT1调节ALD的机制

Figure 1. Mechanism of SIRT1 regulating ALD

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