经内镜逆行胰胆管造影在儿童胰腺疾病诊治中的进展

邹晓平

doi:10.3969/j.issn.1001-5256.2022.12.002

经内镜逆行胰胆管造影在儿童胰腺疾病诊治中的进展

DOI: 10.3969/j.issn.1001-5256.2022.12.002

邹晓平^, ,

1.
南京大学医学院附属泰康仙林鼓楼医院消化科，南京 210046
2.
南京大学医学院附属鼓楼医院消化科，南京 210008

基金项目:

国家自然科学基金中德合作项目 (M-0251);

国家自然科学基金面上项目 (82072652)

利益冲突声明：作者声明不存在利益冲突。

详细信息

通信作者:
邹晓平，zouxp@nju.edu.cn

计量
- 文章访问数: 1406
- HTML全文浏览量: 962
- PDF下载量: 77
- 被引次数: 0
出版历程
- 收稿日期: 2022-10-11
- 录用日期: 2022-11-11
- 出版日期: 2022-12-20

Advances in endoscopic retrograde cholangiopancreatography in diagnosis and treatment of pancreatic diseases in children

Xiaoping ZOU^{,
,}

1.
Department of Gastroenterology, The Affiliated Taikang Xianlin Drum Tower Hospital of Nanjing University Medical School, Nanjing 210046, China
2.
Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

Research funding:

Sino-German Cooperation Program of National Natural Science Foundation (M-0251);

General Program of National Natural Science Foundation of China (82072652)

More Information

Corresponding author: ZOU Xiaoping, zouxp@nju.edu.cn (ORCID: 0000-0003-4147-7051)

摘要

摘要: 儿童胰腺疾病多表现为先天发育异常所致的慢性胰腺炎及外伤所致的胰管断裂等，严重影响患儿生长发育及生活质量。近年来，经内镜逆行胰胆管造影(ERCP)已逐渐成为儿童胰腺疾病诊治最重要的手段。本文结合自身经验，对ERCP及相关技术在儿童胰腺疾病诊治中的临床应用及相关进展进行论述。
- 胰腺疾病 /
- 胰胆管造影术, 内窥镜逆行 /
- 儿童
Abstract: Pancreatic diseases in children mainly include chronic pancreatitis caused by congenital abnormal development and pancreatic duct rupture due to trauma. In recent years, endoscopic retrograde cholangiopancreatography (ERCP) has gradually become the most important method for the diagnosis and treatment of pancreatic diseases in children. With reference to the author's own experience, this article reviews the advances in the clinical application of ERCP and related techniques in the diagnosis and treatment of pancreatic diseases in children.
- Pancreatic Diseases /
- Cholangiopancreatography, Endoscopic Retrograde /
- Child

HTML全文

参考文献(45)

[1]	WAYE JD. Endoscopic retrograde cholangiopancreatography in the infant[J]. Am J Gastroenterol, 1976, 65(5): 461-463.
[2]	TRINGALI A, THOMSON M, DUMONCEAU JM, et al. Pediatric gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Guideline Executive summary[J]. Endoscopy, 2017, 49(1): 83-91. DOI: 10.1055/s-0042-111002.
[3]	HATLANI MA, KORTAN P, MAY G, et al. Wire-guided cannulation versus contrast-guided cannulation in pediatric endoscopic retrograde cholangiopancreatography[J]. Saudi J Gastroenterol, 2015, 21(1): 25-29. DOI: 10.4103/1319-3767.151219.
[4]	PANT C, DESHPANDE A, OLYAEE M, et al. Epidemiology of acute pancreatitis in hospitalized children in the United States from 2000-2009[J]. PLoS One, 2014, 9(5): e95552. DOI: 10.1371/journal.pone.0095552.
[5]	PÁRNICZKY A, ABU-EL-HAIJA M, HUSAIN S, et al. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis[J]. Pancreatology, 2018, 18(2): 146-160. DOI: 10.1016/j.pan.2018.01.001.
[6]	DING XW, YAO YL, WU H, et al. Efficacy and safety of endoscopic retrograde cholangiopancreatography for children with pancreaticobiliary diseases[J]. Chin J Dig Endosc, 2017, 34(2): 99-103. DOI: 10.3760/cma.j.issn.1007-5232.2017.02.006. 丁希伟, 姚玉玲, 吴寒, 等. 经内镜逆行胰胆管造影术在儿童胆胰疾病诊治中的应用价值[J]. 中华消化内镜杂志, 2017, 34(2): 99-103. DOI: 10.3760/cma.j.issn.1007-5232.2017.02.006.
[7]	KOHOUTOVA D, TRINGALI A, PAPPARELLA G, et al. Endoscopic treatment of chronic pancreatitis in pediatric population: Long-term efficacy and safety[J]. United European Gastroenterol J, 2019, 7(2): 270-277. DOI: 10.1177/2050640618817699.
[8]	TRINGALI A, BOSKOSKI I, COSTAMAGNA G. The role of endoscopy in the therapy of chronic pancreatitis[J]. Best Pract Res Clin Gastroenterol, 2008, 22(1): 145-165. DOI: 10.1016/j.bpg.2007.10.021.
[9]	JIAO Y, JI M, LI W, et al. Application of multiple endoscopic retrograde cholangiopanereatography in 18 children with chronic pancreatitis[J]. J Clin Exp Med, 2018, 17(16): 1787-1790. DOI: 10.3969/j.issn.1671-4695.2018.16.032. 焦月, 冀明, 李巍, 等. 儿童慢性胰腺炎多次行ERCP治疗18例临床病例分析[J]. 临床和实验医学杂志, 2018, 17(16): 1787-1790. DOI: 10.3969/j.issn.1671-4695.2018.16.032.
[10]	JIANG W, GAO ZQ, CUI M, et al. Effects of pancreatic stent number on the management of recurrent chronic pancreatitis in children and adolescents[J]. Chin J Dig Endosc, 2019, 36(3): 185-187. DOI: 10.3760/cma.j.issn.1007-5232.2019.03.007. 姜维, 高竹清, 崔淼, 等. 渐进改变支架数量治疗儿童及青少年慢性胰腺炎临床疗效分析[J]. 中华消化内镜杂志, 2019, 36(3): 185-187. DOI: 10.3760/cma.j.issn.1007-5232.2019.03.007.
[11]	JEONG IS, LEE SH, OH SH, et al. Metal stents placement for refractory pancreatic duct stricture in children[J]. World J Gastroenterol, 2018, 24(3): 408-414. DOI: 10.3748/wjg.v24.i3.408.
[12]	SCHWARZENBERG SJ, BELLIN M, HUSAIN SZ, et al. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden[J]. J Pediatr, 2015, 166(4): 890-896.e1. DOI: 10.1016/j.jpeds.2014.11.019.
[13]	LIU W, WANG QM, ZENG HZ, et al. Analysis of the role of endoscopic retrograde cholangiopancreatography in children with pancreaticobiliary diseases[J]. Chin J Pediatr, 2014, 52(5): 328-332. DOI: 10.3760/cma.j.issn.0578-1310.2014.05.003. 刘伟, 王啓名, 曾泓泽, 等. 经内镜逆行胰胆管造影术在儿童青少年胆胰疾病诊治中的临床应用[J]. 中华儿科杂志, 2014, 52(5): 328-332. DOI: 10.3760/cma.j.issn.0578-1310.2014.05.003.
[14]	DUMONCEAU JM, DELHAYE M, TRINGALI A, et al. Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline-Updated August 2018[J]. Endoscopy, 2019, 51(2): 179-193. DOI: 10.1055/a-0822-0832.
[15]	WANG D, BI YW, JI JT, et al. Extracorporeal shock wave lithotripsy is safe and effective for pediatric patients with chronic pancreatitis[J]. Endoscopy, 2017, 49(5): 447-455. DOI: 10.1055/s-0043-104527.
[16]	CHO JM, JEONG IS, KIM HJ, et al. Early adverse events and long-term outcomes of endoscopic sphincterotomy in a pediatric population: a single-center experience[J]. Endoscopy, 2017, 49(5): 438-446. DOI: 10.1055/s-0043-103956.
[17]	LIAO Z, GAO R, WANG W, et al. A systematic review on endoscopic detection rate, endotherapy, and surgery for pancreas divisum[J]. Endoscopy, 2009, 41(5): 439-444. DOI: 10.1055/s-0029-1214505.
[18]	AGHDASSI A, MAYERLE J, KRAFT M, et al. Diagnosis and treatment of pancreatic pseudocysts in chronic pancreatitis[J]. Pancreas, 2008, 36(2): 105-112. DOI: 10.1097/MPA.0b013e31815a8887.
[19]	PATEL PA, GIBSON C, MINHAS KS, et al. Pancreatic pseudocyst drainage in children by image-guided cystogastrostomy and stent insertion[J]. Pediatr Radiol, 2019, 49(13): 1816-1822. DOI: 10.1007/s00247-019-04471-9.
[20]	ROSENFELD EH, VOGEL AM, JAFRI M, et al. Management and outcomes of peripancreatic fluid collections and pseudocysts following non-operative management of pancreatic injuries in children[J]. Pediatr Surg Int, 2019, 35(8): 861-867. DOI: 10.1007/s00383-019-04492-3.
[21]	NABI Z, LAKHTAKIA S, BASHA J, et al. Endoscopic ultrasound-guided drainage of walled-off necrosis in children With fully covered self-expanding metal stents[J]. J Pediatr Gastroenterol Nutr, 2017, 64(4): 592-597. DOI: 10.1097/MPG.0000000000001491.
[22]	WANG SL, ZHAO SB, XIA T, et al. Disconnected pancreatic duct syndrome-Wait! Why not try one more time?[J]. Endoscopy, 2018, 50(7): E188-E189. DOI: 10.1055/a-0605-3076.
[23]	CHEN Y, JIANG Y, QIAN W, et al. Endoscopic transpapillary drainage in disconnected pancreatic duct syndrome after acute pancreatitis and trauma: long-term outcomes in 31 patients[J]. BMC Gastroenterol, 2019, 19(1): 54. DOI: 10.1186/s12876-019-0977-1.
[24]	Chinese Society of Endoscopy, Chinese Medical Association; Endoscopic Physician Branch of Chinese Medical Doctor Association; Beijing Society of Digestive Endoscopy, Beijing Medical Association. Chinese expert consensus on the endoscopic diagnosis and treatment of pancreatic fistula (2020, Beijing)[J]. J Clin Hepatol, 2021, 37(4): 803-808. DOI: 10.3969/j.issn.1001-5256.2021.04.016. 中华医学会消化内镜学分会, 中国医师协会内镜医师分会, 北京医学会消化内镜学分会. 中国胰瘘消化内镜诊治专家共识(2020, 北京)[J]. 临床肝胆病杂志, 2021, 37(4): 803-808. DOI: 10.3969/j.issn.1001-5256.2021.04.016.
[25]	CUI GX, YANG JF, JIN HB, et al. Endoscopic diagnosis and treatment of pancreas divisum with recurrent acute pancreatitis in children and teenagers[J]. Chin J Dig Endosc, 2017, 34(2): 104-107. DOI: 10.3760/cma.j.issn.1007-5232.2017.02.007. 崔光星, 杨建锋, 金杭斌, 等. 儿童及青少年胰腺分裂伴急性复发性胰腺炎的内镜诊治分析[J]. 中华消化内镜杂志, 2017, 34(2): 104-107. DOI: 10.3760/cma.j.issn.1007-5232.2017.02.007.
[26]	CAI Q, KEILIN S, OBIDEEN K, et al. Intraduodenal hydrochloric acid infusion for facilitation of cannulation of the dorsal pancreatic duct at ERCP in patients with pancreas divisum: a preliminary study[J]. Am J Gastroenterol, 2010, 105(6): 1450-1451. DOI: 10.1038/ajg.2010.88.
[27]	LU Y, XU B, CHEN L, et al. Endoscopic intervention through endoscopic retrograde cholangiopancreatography in the management of symptomatic pancreas divisum: A long-term follow-up study[J]. Gut Liver, 2016, 10(3): 476-482. DOI: 10.5009/gnl15362.
[28]	LIN TK, ABU-EL-HAIJA M, NATHAN JD, et al. Pancreas divisum in pediatric acute recurrent and chronic pancreatitis: Report from INSPPIRE[J]. J Clin Gastroenterol, 2019, 53(6): e232-e238. DOI: 10.1097/MCG.0000000000001063.
[29]	KAMISAWA T, KANEKO K, ITOI T, et al. Pancreaticobiliary maljunction and congenital biliary dilatation[J]. Lancet Gastroenterol Hepatol, 2017, 2(8): 610-618. DOI: 10.1016/S2468-1253(17)30002-X.
[30]	KAMISAWA T, ANDO H, HAMADA Y, et al. Diagnostic criteria for pancreaticobiliary maljunction 2013[J]. J Hepatobiliary Pancreat Sci, 2014, 21(3): 159-161. DOI: 10.1002/jhbp.57.
[31]	MORINE Y, SHIMADA M, TAKAMATSU H, et al. Clinical features of pancreaticobiliary maljunction: update analysis of 2nd Japan-nationwide survey[J]. J Hepatobiliary Pancreat Sci, 2013, 20(5): 472-480. DOI: 10.1007/s00534-013-0606-2.
[32]	ZENG JQ, DENG ZH, YANG KH, et al. Endoscopic retrograde cholangiopancreatography in children with symptomatic pancreaticobiliary maljunction: A retrospective multicenter study[J]. World J Gastroenterol, 2019, 25(40): 6107-6115. DOI: 10.3748/wjg.v25.i40.6107.
[33]	GROMSKI MA, LEHMAN GA, ZYROMSKI NJ, et al. Annular pancreas: endoscopic and pancreatographic findings from a tertiary referral ERCP center[J]. Gastrointest Endosc, 2019, 89(2): 322-328. DOI: 10.1016/j.gie.2018.09.008.
[34]	LIN TK, FISHMAN DS, GIEFER MJ, et al. Functional pancreatic sphincter dysfunction in children: Recommendations for diagnosis and management[J]. J Pediatr Gastroenterol Nutr, 2019, 69(6): 704-709. DOI: 10.1097/MPG.0000000000002515.
[35]	GUELRUD M, MORERA C, RODRIGUEZ M, et al. Sphincter of Oddi dysfunction in children with recurrent pancreatitis and anomalous pancreaticobiliary union: an etiologic concept[J]. Gastrointest Endosc, 1999, 50(2): 194-199. DOI: 10.1016/s0016-5107(99)70224-5.
[36]	USATIN D, FERNANDES M, ALLEN IE, et al. Complications of endoscopic retrograde cholangiopancreatography in pediatric patients; A systematic literature review and meta-analysis[J]. J Pediatr, 2016, 179: 160-165.e3. DOI: 10.1016/j.jpeds.2016.08.046.
[37]	ROSEN JD, LANE RS, MARTINEZ JM, et al. Success and safety of endoscopic retrograde cholangiopancreatography in children[J]. J Pediatr Surg, 2017, 52(7): 1148-1151. DOI: 10.1016/j.jpedsurg.2017.01.051.
[38]	TROENDLE DM, ABRAHAM O, HUANG R, et al. Factors associated with post-ERCP pancreatitis and the effect of pancreatic duct stenting in a pediatric population[J]. Gastrointest Endosc, 2015, 81(6): 1408-1416. DOI: 10.1016/j.gie.2014.11.022.
[39]	MERCIER C, PIOCHE M, ALBUISSON E, et al. Safety of endoscopic retrograde cholangiopancreatography in the pediatric population: a multicenter study[J]. Endoscopy, 2021, 53(6): 586-594. DOI: 10.1055/a-1209-0155.
[40]	CHOUDHARY A, BECHTOLD ML, ARIF M, et al. Pancreatic stents for prophylaxis against post-ERCP pancreatitis: a meta-analysis and systematic review[J]. Gastrointest Endosc, 2011, 73(2): 275-282. DOI: 10.1016/j.gie.2010.10.039.
[41]	URUSHIHARA N, FUKUMOTO K, FUKUZAWA H, et al. Recurrent pancreatitis caused by pancreatobiliary anomalies in children with annular pancreas[J]. J Pediatr Surg, 2010, 45(4): 741-746. DOI: 10.1016/j.jpedsurg.2009.05.027.
[42]	KEIL R, DRÁBEK J, LOCHMANNOVÁ J, et al. ERCP in infants, children, and adolescents-Different roles of the methods in different age groups[J]. PLoS One, 2019, 14(1): e0210805. DOI: 10.1371/journal.pone.0210805.
[43]	AGARWAL J, NAGESHWAR REDDY D, TALUKDAR R, et al. ERCP in the management of pancreatic diseases in children[J]. Gastrointest Endosc, 2014, 79(2): 271-278. DOI: 10.1016/j.gie.2013.07.060.
[44]	GIEFER MJ, KOZAREK RA. Technical outcomes and complications of pediatric ERCP[J]. Surg Endosc, 2015, 29(12): 3543-3550. DOI: 10.1007/s00464-015-4105-1.
[45]	TROENDLE DM, BARTH BA. Pediatric considerations in endoscopic retrograde cholangiopancreatography[J]. Gastrointest Endosc Clin N Am, 2016, 26(1): 119-136. DOI: 10.1016/j.giec.2015.08.004.