肝细胞极性调控

毛元鹏; 魏红山

doi:10.3969/j.issn.1001-5256.2022.11.043

肝细胞极性调控

DOI: 10.3969/j.issn.1001-5256.2022.11.043

毛元鹏¹,
魏红山^{1, 2, , ,}

1.
北京大学地坛医院教学医院消化科，北京 100015
2.
首都医科大学附属北京地坛医院消化科，北京 100015

基金项目:

北京市医院管理中心消化内科学科协同发展中心专项 (XXZ0404);

北京市自然科学基金 (7202071);

国家自然科学基金 (82170541)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：毛元鹏负责拟定写作思路，资料分析，撰写论文；魏红山负责课题设计，指导撰写论文并最终定稿。

详细信息

通信作者:
魏红山，drwei@ccmu.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2022-03-15
- 录用日期: 2022-04-25
- 出版日期: 2022-11-20

Regulation of hepatocyte polarity

Yuanpeng MAO¹,
Hongshan WEI^{1, 2
, ,
,}

1.
Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, China
2.
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Research funding:

The Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals (XXZ0404);

Natural Science Foundation of Beijing (7202071);

National Natural Science Foundation of China (82170541)

More Information

Corresponding author: WEI Hongshan, drwei@ccmu.edu.cn(ORCID: 0000-0001-8893-653X)

摘要

摘要: 肝细胞是高度极化的细胞。肝细胞极性的建立和维持对肝细胞的诸多功能至关重要。肝细胞极性的动态稳定与诸多因素相关，包括细胞间连接、极性蛋白复合体以及多个信号通路。当极性受到破坏，肝细胞功能往往出现异常，最终可能导致各类肝脏疾病的发生。目前，关于肝细胞极性调控相关研究仍然较少，多种关键因素尚未得到完全阐明。本文简要介绍了近年来肝细胞极性调控相关研究进展。
- 肝疾病 /
- 肝细胞 /
- 细胞极性
Abstract: Hepatocytes are highly polarized cells, and the establishment and maintenance of hepatocyte polarity are critical for the various functions of hepatocytes. The dynamic stability of hepatocyte polarity is associated with various factors including intercellular junctions, polarity complex proteins, and several signaling pathways. Abnormal hepatocyte function is often observed when polarity gets destroyed, which may eventually lead to various liver diseases. At present, there are still a few studies on the regulation of hepatocyte polarity, and many key factors have not been fully elucidated. This article briefly introduces the recent research advances in the regulation of hepatocyte polarity.
- Liver Diseases /
- Hepatocytes /
- Cell Polarity

HTML全文

表 1 肝细胞极性紊乱所致胆汁淤积性肝病相关蛋白质/基因

Table 1. Proteins/genes associated with cholestatic liver diseases caused by disorder of hepatocyte polarity

编码基因	蛋白质主要功能	相关疾病	相关报道
TJP2	TJ构成	家族性高胆碱血症	Carlton(2003)
CLDN1	TJ构成	新生儿鱼鳞病硬化性胆管炎综合征	Hadj-Rabia(2004)
ATP8B1	磷脂翻转酶	进行性家族性肝内胆汁淤积症	Bull(1998)
ABCB4	磷脂输出泵	进行性家族性肝内胆汁淤积症	Deleuze(1996)
ABCB11	胆汁盐输出泵	进行性家族性肝内胆汁淤积症	Strautnieks(1998)
ABCC2	小管有机阴离子转运	肝内和阻塞性胆汁淤积	Trauner(1997)
VPS33B	囊泡细胞内转运和蛋白质相互作用	关节挛缩-肾功能障碍-胆汁淤积综合征	Gissen(2004)
MYO5B	小管形成；促进ABC转运蛋白正常运输	进行性家族性肝内胆汁淤积症	Girard(2014)

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