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表现为进展性多发血管损伤的特发性嗜酸粒细胞增多综合征1例报告
DOI: 10.3969/j.issn.1001-5256.2022.11.027
A case of idiopathic hypereosinophilic syndrome presenting with progressive multiple vascular lesions
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Key words:
- Eosinophilia /
- Vascular System Injuries /
- Glucocorticoids
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图 1 肝组织HE染色结果(×100)
注：多个小叶可见肝窦扩张充血(中央静脉周围为主)。
Figure 1. HE staining results of liver tissue(×100)
图 2 骨髓涂片示嗜酸粒细胞增多(瑞氏染色，×400)
Figure 2. Bone marrow smear showing eosinophilia (Wright's staining, ×400)
图 3 2019年9月第一次上腹部CT
注：门静脉期示肝右叶萎缩，肝左叶淤血肿大伴周边坏死，门静脉左支增宽(1.7 cm)，门静脉右支迂曲变窄，肝周少量积液，胆囊炎，脾肿大。
Figure 3. Upper abdominal CT in September 2019
图 4 2020年6月第二次上腹部CT
注：肝左叶淤血肿大伴周边坏死较2019年明显好转。
Figure 4. Upper abdominal CT in June 2020
表 1 血常规变化
Table 1. Changes of blood routine
日期 WBC (×109/L) 中性粒细胞计数(×109/L) EOS (×109/L) RBC (×1012/L) 血红蛋白(g/L) PLT (×109/L) 2011.11.19 11.40 4.44 2.56 4.93 145 119 2015.12.30 12.53 6.30 3.75 5.44 166 202 2018.04.15 8.98 5.63 2.07 4.78 156 94 2018.09.06 6.93 3.58 1.70 4.62 134 111 2018.10.15 7.96 5.61 0.53 5.56 154 87 2019.03.01 5.48 4.69 0.62 5.04 132 86 2019.03.10 5.71 3.56 0.09 4.89 139 89 2019.04.01 6.71 5.72 0.15 4.23 127 80 2019.12.10 5.54 4.29 0.27 5.05 130 90 2020.06.06 6.17 3.91 0.31 4.65 137 81 注：2018年9月6日开始口服强的松10 mg 1次/d；2019年3月1日开始强的松60 mg 1次/d 1周，40 mg 1次/d 1周，20 mg 1次/d 2周，10 mg 1次/d维持。 
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