氧化应激在急性肝损伤中的作用

廖月; 何毅怀; 罗亚文

doi:10.3969/j.issn.1001-5256.2022.10.039

氧化应激在急性肝损伤中的作用

DOI: 10.3969/j.issn.1001-5256.2022.10.039

遵义医科大学附属医院感染科，贵州遵义 563000

基金项目:

国家自然科学基金 (82160370);

国家自然科学基金 (81560110);

贵州省科技计划项目 (Qian Ke He Ji Chu -ZK〔2022〕 Yi Ban 642)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：廖月负责查阅文献及撰写文章；何毅怀、罗亚文参与修改文章的关键内容。

详细信息

通信作者:
罗亚文，luoyw719@163.com

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出版历程
- 收稿日期: 2022-02-27
- 录用日期: 2022-04-02
- 出版日期: 2022-10-20

Role of oxidative stress in acute liver injury

Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China

Research funding:

National Natural Science Foundation of China (82160370);

National Natural Science Foundation of China (81560110);

Science and Technology Plan Project of Guizhou Province (Qian Ke He Ji Chu -ZK〔2022〕 Yi Ban 642)

More Information

Corresponding author: LUO Yawen, luoyw719@163.com(ORCID: 0000-0002-8845-1265)

摘要

摘要: 急性肝损伤常由病毒感染、酒精、药物、毒物、代谢异常等原因引起。氧化应激是急性肝损伤及其他肝病发生发展的共同病理生理机制。急性肝损伤发生后，肝细胞功能受损，引起氧化应激；而持续或高强度的氧化应激将增加肝细胞死亡的风险，导致一系列肝脏疾病。氧化应激主要与Nrf2、NF-κB等信号通路相关。因此，了解氧化应激参与肝损伤的发生发展机制及相关通路至关重要。本文介绍了氧化系统及抗氧化系统、氧化应激与损伤因素、氧化应激与肝损伤相关通路，以期为急性肝损伤的治疗靶点选择及相关临床研究提供参考。
- 性肝损伤 /
- 氧化应激 /
- NF-E2相关因子2 /
- NF-κB
Abstract: Acute liver injury (ALI) is often caused by virus infection, alcohol, drugs, toxin, and metabolic disorder, and oxidative stress is a common pathophysiological mechanism in the development and progression of ALI and other liver diseases. Hepatocyte function is impaired after ALI, which further causes oxidative stress, and persistent or high-intensive oxidative stress may increase the risk of hepatocyte death and thus result in a series of liver diseases. Oxidative stress is mainly associated with the signaling pathways including nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B. Therefore, it is of great importance to understand the mechanism of oxidative stress in the development and progression of liver injury and related pathways. This article introduces oxidative system and antioxidative system, oxidative stress and damage factors, and oxidative stress and pathways associated with liver injury, so as to provide a reference for the selection of therapeutic targets for ALI and related clinical research.
- Acute Liver Injury /
- Oxidative Stress /
- NF-E2-Related Factor 2 /
- NF-kappa B

HTML全文

图 1 线粒体氧化磷酸化生成电子与抗氧化剂清除O₂^-的简要示意图

Figure 1. Brief schematic figure of generation of electrons by mitochonrial oxidative phosphorylation and O₂^- scavenging by antioxidants

下载: 全尺寸图片幻灯片

图 2 损伤因素与氧化应激简要示意图

Figure 2. Brief schematic figure of damage factor and oxidative stress

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图 3 氧化应激主要通路简要示意图

Figure 3. Brief schematic figure of main pathway of oxdative stress

下载: 全尺寸图片幻灯片

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