异种肝移植中的急性体液性排斥反应

章忠强; 梁硕洲; 司中洲; 齐海智

doi:10.3969/j.issn.1001-5256.2022.10.003

异种肝移植中的急性体液性排斥反应

DOI: 10.3969/j.issn.1001-5256.2022.10.003

章忠强^{1, 2},
梁硕洲^{1, 2},
司中洲^{1, 2, , ,},
齐海智^{1, 2}

1.
中南大学湘雅二医院肝脏移植科，长沙 410011
2.
中南大学湘雅二医院移植医学研究中心，长沙 410011

基金项目:

湖南省重点研发项目 (2021DK2002)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：章忠强、梁硕洲负责撰写论文；司中洲、齐海智负责写作思路，指导撰写、修改文章并最后定稿。

详细信息

通信作者:
司中洲，zhongzsi@csu.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-30
- 录用日期: 2020-08-31
- 出版日期: 2022-10-20

Acute humoral rejection in liver xenotransplantation

Zhongqiang ZHANG^{1, 2},
Shuozhou LIANG^{1, 2},
Zhongzhou SI^{1, 2
, ,
,},
Haizhi QI^{1, 2}

1.
Department of Liver Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China
2.
Transplant Medicine Research Center, The Second Xiangya Hospital of Central South University, Changsha 410011, China

Research funding:

Hunan Provincial Key Research Project (2021DK2002)

More Information

Corresponding author: SI Zhongzhou, zhongzsi@csu.edu.cn(ORCID: 0000-0022-8875-9651)

摘要

摘要: 肝移植是各种终末期肝病最为有效的治疗手段。肝脏供体的严重短缺导致大量终末期肝病患者死亡。利用基因工程技术研发的基因工程猪作为供体，是目前最有可能解决肝脏供体短缺的办法之一。虽然，目前基因工程猪-非人灵长类动物异种肝移植术后发生的急性排斥反应、血小板减少症、凝血异常等问题阻碍了异种肝脏的临床应用，但基因工程技术的发展以及新型免疫抑制剂的应用，异种肝移植急性排斥反应在一定程度上得到了控制。目前，急性体液性排斥反应可能是导致较长时间存活的移植物失功的主要因素。因此，明确异种肝移植中的急性体液性排斥反应的机制及处理方法，对于目前我国今后开展异种肝移植研究具有重要的意义。
- 肝移植 /
- 移植, 异种 /
- 动物, 基因修饰 /
- 移植物排斥
Abstract: Liver transplantation is a curable therapy to save the life of patients with end-stage liver diseases of different causes. The serious shortage of liver donors led to the death of a large number of patients with end-stage liver disease. Genetic-engineered pigs used for xenotransplantation are one of the potential solutions to alleviate the liver donor shortage, but currently clinical application of such xenogeneic liver grafts is hindered by acute rejection, thrombocytopenia, and coagulation dysfunctions in patients. The development of genetic-engineering technology and the application of new immunosuppressants have controlled the acute rejection of liver xenotransplantation to some extent. However, acute humoral rejection may become another major issue for the long-term graft failure. This review summarized and discussed the potential and underlying mechanisms and preventive measures of acute humoral rejection in liver xenotransplantation.
- Liver Transplantation /
- Transplantation, Heterologous /
- Animals, Genetically Modified /
- Graft Rejection

HTML全文

图 1 异种肝移植术后发生超急性排斥反应(野生型猪肝供体移植到恒河猴)

Figure 1. Acute rejection in liver xenotransplantation (WT pig to rhesus)

下载: 全尺寸图片幻灯片

表 1 基因工程猪-非人灵长类动物异种肝移植受体存活时间

Table 1. Survival time of genetically engineered pig - nonhuman primate xenotransplantation recipients

年份	国家	研究者	移植类型	移植数量(只)	最长存活时间(d)
2000	西班牙	Ramirez等^[10]	原位	2	8
2010	美国	Esker等^[11]	原位	10	7
2012	美国	Kim等^[12]	原位	3	9
2013	中国	Dou等^[13]	异位(辅助)	1	14
2014	美国	Yeh等^[14]	异位(辅助)	1	15
2016	美国	Navarro-Alvarez等^[15]	原位	6	7
2016	美国	Shah等^[16]	原位	1	25
2017	美国	Shah等^[17]	原位	4	29
2021	中国	Dou等^[18]	异位(辅助)	1	26

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