原发性胆汁性胆管炎的治疗进展
DOI: 10.3969/j.issn.1001-5256.2022.09.035
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:吕行、李婷负责收集数据,资料分析,撰写论文;孙晓东、周建鹏、王东霞负责修改文章;吕国悦提供写作思路,指导撰写文章,修改文章并最后定稿。
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摘要: 原发性胆汁性胆管炎(PBC)是一种自身免疫性疾病,常见于中年女性。疾病进展可导致肝硬化、肝衰竭。熊去氧胆酸和奥贝胆酸为美国食品药品管理局唯一批准的一、二线用药,但是约有40%的患者对熊去氧胆酸应答不敏感,多种二线用药如贝特类药物、免疫抑制剂的研究正在开展,而肝移植是终末期PBC治疗的唯一手段。本文就PBC近年来的治疗研究进展及相关机制进行综述,旨在为临床实践提供参考。Abstract: Primary biliary cholangitis (PBC) is an autoimmune disease commonly observed in middle-aged women, and it may progress to liver cirrhosis and liver failure. Ursodeoxycholic acid and obeticholic acid are the only first - and second-line drugs approved by the FDA, but about 40% of patients are insensitive to UDCA. Studies are being conducted on a variety of second-line drugs such as fibrates and immunosuppressive drugs, and liver transplantation is the only treatment method for end-stage PBC. This article reviews the research advances in the treatment of PBC and related mechanisms, in order to provide a reference for clinical practice.
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Key words:
- Primary Biliary Cholangitis /
- Drug Therapy /
- Liver Transplantation
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