炎症反应在慢加急性肝衰竭中的作用及治疗策略

徐华谦; 李雪; 汤善宏

doi:10.3969/j.issn.1001-5256.2022.08.041

炎症反应在慢加急性肝衰竭中的作用及治疗策略

DOI: 10.3969/j.issn.1001-5256.2022.08.041

徐华谦^{1, 2},
李雪^{1, 2},
汤善宏^{1, 2, , ,}

1.
成都中医药大学医学与生命科学学院，成都 610072
2.
西部战区总医院消化内科，成都 610083

基金项目:

四川省卫生健康委员会科研课题 (20PJ180)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：徐华谦参与拟定写作思路，收集分析文献，论文撰写及修改；李雪参与指导撰写文章及论文修改；汤善宏负责拟定写作思路，指导撰写文章与最后定稿。

详细信息

通信作者:
汤善宏，15928956390@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-29
- 录用日期: 2022-02-17
- 出版日期: 2022-08-20

Research advances in the role of inflammatory response and related treatment strategies in acute-on-chronic liver failure

Huaqian XU^{1, 2},
Xue LI^{1, 2},
Shanhong TANG^{1, 2
, ,
,}

1.
School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
2.
Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China

Research funding:

Scientific Research Project of Sichuan Provincial Health Commission (20PJ180)

More Information

Corresponding author: TANG Shanhong, 15928956390@163.com(ORCID: 0000-0001-6652-2942)

摘要

摘要: 慢加急性肝衰竭(ACLF)是在慢性肝病基础上，由一系列诱因导致肝功能迅速恶化的临床综合征，以多器官衰竭和短期高病死率为突出特征。系统性炎症的发生是ACLF疾病进展的重要影响因素之一，是机体对感染的自然防御，但当炎症介质过度释放打破原有的“促炎和抗炎”动态平衡，反而会加重肝损伤甚至发生失代偿。因此，炎症反应的强度与ACLF患者预后密切相关，但目前对于炎症反应对ACLF患者的影响以及如何应对炎症风暴的关注度还不够，故本文归纳了目前炎症反应对ACLF的影响及其治疗进展，为临床中ACLF的诊疗提供思路。
- 慢加急性肝功能衰竭 /
- 炎症 /
- 治疗学 /
- 预后
Abstract: Acute-on-chronic liver failure (ACLF) is a clinical syndrome with rapid deterioration of liver function caused by a series of predisposing factors on the basis of chronic liver diseases, and it is characterized by multiple organ failure and high short-term mortality. The onset of systemic inflammation is one of the important influencing factors for the progression of ACLF and is the body's natural defense against infection; however, the excessive release of inflammatory mediators breaks the original dynamic balance between "pro-inflammation" and "anti-inflammation", which may aggravate liver function impairment and even lead to decompensation. Therefore, the intensity of inflammatory response is closely associated with the prognosis of patients with ACLF, while at present, not enough attention has been paid to the impact of inflammatory response on patients with ACLF and the measures to deal with cytokine storm. Therefore, this article summarizes the impact of inflammatory response on ACLF and related advances in treatment, so as to provide ideas for the diagnosis and treatment of ACLF in clinical practice.
- Acute-On-Chronic Liver Failure /
- Inflammation /
- Therapeutics /
- Prognosis

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