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转录因子阴阳1在肝细胞癌中的作用

周洁 华芸豪 王晓美 牛俊奇

引用本文:
Citation:

转录因子阴阳1在肝细胞癌中的作用

DOI: 10.3969/j.issn.1001-5256.2022.08.039
基金项目: 

国家自然科学基金 (81970519)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:周洁负责资料搜集,资料分析与总结,撰写论文;华芸豪参与搜集资料,修改论文;王晓美负责拟定写作思路,指导撰写文章;牛俊奇负责论文写作方向设计并最后定稿。
详细信息
    通信作者:

    牛俊奇,junqiniu@jlu.edu.cn

Role of transcription factor Yin Yang 1 in hepatocellular carcinoma

Research funding: 

Natural Science Foundation of China (81970519)

More Information
  • 摘要: 肝细胞癌(HCC)起病隐匿,大多数患者确诊时进展至中晚期,错过了最佳治疗时机,往往预后不良。转录因子阴阳1(YY1)是一种多功能转录因子,可调节多种重要基因的转录,在多种肿瘤中发挥重要作用。既往研究显示,YY1影响HCC许多生物学行为,如增殖、凋亡、迁移和血管生成,还与HCC的耐药性及不良预后密切相关。本文系统总结了YY1在HCC发生发展中的作用相关研究进展,为HCC的治疗提供一定的理论依据。

     

  • 图  1  YY1促进HCC发生

    Figure  1.  YY1 promotes HCC occurrence

    图  2  YY1促进HCC细胞增殖

    Figure  2.  YY1 promotes HCC cells proliferation

    图  3  YY1抑制HCC细胞凋亡

    Figure  3.  YY1 inhibits apoptosis of HCC cells

    图  4  YY1促进HCC侵袭和迁移

    Figure  4.  YY1 promotes HCC invasion and migration

    图  5  YY1促进HCC血管生成

    Figure  5.  YY1 promotes HCC angiogenesis

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  • 收稿日期:  2022-02-08
  • 录用日期:  2022-03-10
  • 出版日期:  2022-08-20
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