G蛋白偶联受体在肝脏疾病中的作用

陈蕊; 章坤; 郭北辰; 李雨韩; 洪伟; 韩涛

doi:10.3969/j.issn.1001-5256.2022.07.042

G蛋白偶联受体在肝脏疾病中的作用

DOI: 10.3969/j.issn.1001-5256.2022.07.042

陈蕊^{1, 2, 3},
章坤⁴,
郭北辰^{1, 2, 3},
李雨韩^{1, 2, 3},
洪伟^4, , ,,
韩涛^{1, 2, 3, 5, , ,}

1.
天津医科大学人民临床学院消化(肝病)科，天津 300121
2.
天津医科大学三中心临床学院消化(肝病)科，天津 300170
3.
天津市第三中心医院消化(肝病)科，天津 300170
4.
天津医科大学基础医学院组织胚胎学系，天津 300070
5.
南开大学人民医院消化(肝病)科，天津 300121

基金项目:

国家自然科学基金 (81870429)

利益冲突声明: 所有作者均声明不存在利益冲突。

作者贡献声明: 陈蕊撰写论文; 郭北辰、李雨韩负责查阅及分析文献; 章坤修改论文; 韩涛、洪伟负责拟定写作思路、指导文章撰写。

详细信息

通信作者:
洪伟，hongwei@tmu.edu.cn

韩涛，hantaomd@126.com

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- 文章访问数: 601
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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-10
- 录用日期: 2022-01-07
- 出版日期: 2022-07-20

Role of G protein-coupled receptors in liver diseases

Rui CHEN^{1, 2, 3},
Kun ZHANG⁴,
Beichen GUO^{1, 2, 3},
Yuhan LI^{1, 2, 3},
Wei HONG^{4
, ,
,},
Tao HAN^{1, 2, 3, 5
, ,
,}

1.
Department of Gastroenterology and Hepatology, Tianjin Union Medical Center, Tianjin Medical University, Tianjin 300121, China
2.
Department of Hepatology and Gastroenterology, The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China
3.
Department of Hepatology and Gastroenterology, The Third Central Hospital of Tianjin, Tianjin 300170, China
4.
Department of Histology and Embryology, School of Basic Medicine, Tianjin Medical University, Tianjin 300070, China
5.
Department of Gastroenterology and Hepatology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China

Research funding:

National Natural Science Foundation of China (81870429)

More Information

Corresponding author: HONG Wei, hongwei@tmu.edu.cn(ORCID: 0000-0003-1199-4365); HAN Tao, hantaomd@126.com(ORCID: 0000-0003-4216-6968)

摘要

摘要: 慢性肝病严重威胁人们的健康，近年来研究发现一些G蛋白偶联受体(GPCR)及相关信号通路参与肝脏的生理病理过程并与非酒精性脂肪性肝病、肝硬化及肝癌等肝脏疾病相关。本文综述GPCR与肝脏疾病的关联，以期为肝脏疾病诊疗提供新策略。
- 受体, G-蛋白偶联 /
- 非酒精性脂肪性肝病 /
- 肝硬化 /
- 癌, 肝细胞 /
- 病理过程
Abstract: Chronic liver diseases greatly threaten the health of the Chinese people, and recent studies have found that some G protein-coupled receptors (GPCRs) and related signaling pathways are involved in the physiopathological processes of the liver and are associated with various liver diseases such as nonalcoholic fatty liver disease, liver cirrhosis, and liver cancer. This article reviews the association between GPCRs and liver diseases, so as to provide new strategies for the diagnosis and treatment of liver diseases.
- Receptors, G-Protein-Coupled /
- Non-alcoholic Fatty Liver Disease /
- Liver Cirrhosis /
- Carcinoma, Hepatocellular /
- Pathologic Processes

HTML全文

图 1 GPCR及配体在HCC中的作用机制

Figure 1. The mechanism of GPCR and ligand in HCC

下载: 全尺寸图片幻灯片

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