吲哚胺2, 3-双加氧酶——多种肝病中发挥双刃剑作用的重要介质

叶森; 王宏宾; 付永

doi:10.3969/j.issn.1001-5256.2022.06.046

吲哚胺2, 3-双加氧酶——多种肝病中发挥双刃剑作用的重要介质

DOI: 10.3969/j.issn.1001-5256.2022.06.046

叶森¹,
王宏宾^2, , ,,
付永^3, , ,

1.
青海大学研究生院，西宁 810016
2.
青海大学附属医院肝胆胰外科，西宁 810001
3.
青海省畜牧兽医科学院，西宁 810016

基金项目:

国家自然科学基金 (31960708);

青海省应用基础研究 (2021-ZJ-724)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：王宏宾对研究的思路、设计有关键贡献；叶森负责研究内容的获取、分析和解释；付永负责审阅修改文章关键内容。

详细信息

通信作者:
王宏宾，13897649826@163.com

付永，qhfuyong@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-10-15
- 录用日期: 2021-11-17
- 出版日期: 2022-06-20

Indoleamine 2, 3-dioxygenase: An important medium with the role of a double-edged sword in various liver diseases

Sen YE¹,
Hongbin WANG^{2
, ,
,},
Yong FU^{3
, ,
,}

1.
Graduate School of Qinghai University, Xining 810016, China
2.
Department of Hepatopancre-atobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining 810001, China
3.
Qinghai Academy of Animal Husbandry and Veterinary Sciences, Xining 810016, China

Research funding:

National Natural Science Foundation of China (31960708);

Applied Basic Research of Qinghai Province (2021-ZJ-724)

More Information

Corresponding author: WANG Hongbin, 13897649826@163.com(ORCID: 0000-0002-8865-3238); FU Yong, qhfuyong@163.com(ORCID: 0000-0003-3354-9107)

摘要

摘要: 吲哚胺2, 3-双加氧酶(IDO)是一种重要的免疫调节酶，可降解哺乳动物必需氨基酸色氨酸水平，通过犬尿氨酸途径催化起始和限速步骤并产生多种代谢产物参与免疫应答。IDO一方面对微环境发挥免疫抑制作用，导致感染、肿瘤细胞免疫逃逸等；另一方面，对细菌、寄生虫等病原体同样发挥抑制作用，一定程度上保护机体免受病原体的侵害。因此，IDO被认为是在多种肝脏疾病发生发展中具有双刃剑作用的重要介质。本文就IDO在病毒性肝炎、肝纤维化、肝硬化、肝癌、肝棘球蚴病中的最新研究进展作一综述。
- 肝疾病 /
- 吲哚胺2, 3-双加氧酶 /
- 免疫系统现象
Abstract: Indoleamine 2, 3-dioxygenase (IDO) is an important immunoregulatory enzyme, which can degrade the level of the mammalian essential amino acid tryptophan (TRP), catalyze the initiation and rate-limiting steps through the kynurenine pathway, and produce a variety of metabolites to participate in the immune response. On the one hand, IDO plays an immunosuppressive role in microenvironment and thus leads to infection and immune escape of tumor cells; on the other hand, IDO also exerts an inhibitory effect on the pathogens such as bacteria and parasites and thus protects the body from the harm of pathogens to a certain extent. Therefore, IDO is considered an important medium with the role of a double-edged sword in the development and progression of various liver diseases. This article reviews the latest research advances in IDO in viral hepatitis, liver fibrosis, liver cirrhosis, liver cancer, and hepatic echinococcosis.
- Liver Diseases /
- Indoleamine 2, 3-Dioxygenase /
- Immune System Phenomena

HTML全文

图 1 色氨酸-犬尿氨酸代谢途径

注：TDO，色氨酸2, 3-双加氧酶；KMO，犬尿氨酸-3-羟化酶；3-HK，3-羟基犬尿氨酸；KYNU，犬尿氨酸酶；3-HAA，3-羟邻氨苯甲酸；3-HAO，3-HAA氧化酶；QUIN，喹啉酸；NAD⁺，烟酰胺腺嘌岭二核苷酸；NADP⁺，烟酰胺腺嘌呤二核苷酸磷酸；KATS，犬尿氨酸转氨酶；KYNA，犬尿喹啉酸。

Figure 1. Tryptophan kynurenine metabolic pathway

下载: 全尺寸图片幻灯片

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