肠道菌群和色氨酸代谢在非酒精性脂肪性肝病中的作用

钟庆玲; 李良平

doi:10.3969/j.issn.1001-5256.2022.06.040

肠道菌群和色氨酸代谢在非酒精性脂肪性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2022.06.040

钟庆玲^{1, 2},
李良平^2, , ,

1.
电子科技大学医学院，成都 610054
2.
电子科技大学附属医院·四川省人民医院消化内科，成都 610072

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：钟庆玲负责撰写论文；李良平负责指导撰写文章并最后定稿。

详细信息

通信作者:
李良平，18981838872@163.com

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出版历程
- 收稿日期: 2021-10-09
- 录用日期: 2021-11-12
- 出版日期: 2022-06-20

Role of gut microbiota and tryptophan metabolism in nonalcoholic fatty liver disease

Qingling ZHONG^{1, 2},
Liangping LI^{2
, ,
,}

1.
School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China
2.
Department of Gastroenterology, Sichuan Provincial People's Hospital & The Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu 610072, China

More Information

Corresponding author: LI Liangping, 18981838872@163.com (ORCID: 0000-0004-1808-0950)

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)是多系统功能紊乱累及肝脏的表现，从单纯性脂肪变性到非酒精性脂肪性肝炎、肝纤维化、肝硬化和肝细胞癌。越来越多的研究揭示肠道菌群失调及代谢产物改变在NAFLD中的重要性。而肠道菌群产生色氨酸代谢产物具有改善肠道屏障功能、调节异常的糖脂代谢、减轻胰岛素抵抗及炎症反应等作用。本文旨在综述肠道菌群、色氨酸和其代谢物以及二者间相互作用对NAFLD的影响。
- 非酒精性脂肪性肝病 /
- 胃肠道微生物组 /
- 色氨酸
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a manifestation of multi-system dysfunction involving the liver, ranging from simple hepatic steatosis to nonalcoholic steatohepatitis, liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. An increasing number of studies have shown the importance of the changes in gut microbiota dysbiosis and its metabolites in NAFLD. Tryptophan and its derivatives produced by gut microbiota have the effects on improving intestinal barrier function, regulating abnormal glucose and lipid metabolism, and alleviating insulin resistance and inflammatory response. This article reviews gut microbiota, tryptophan and its metabolites, and the effect of their interaction on NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Gastrointestinal Microbiome /
- Tryptophan

HTML全文

图 1 色氨酸通过犬尿氨酸、吲哚、5-HT的代谢途径

注：黑色箭头线表示宿主途径，蓝色虚线箭头线表示微生物途径。TDO，色氨酸2，3-双加氧酶；KYNU，犬尿氨酸酶；KMO，犬尿酸-3-单加氧酶；KAT，犬尿氨酸氨基转移酶；KYNA，犬尿喹啉酸；3H-KYN，3-羟基犬尿氨酸；Xa，黄尿酸；3-HAA，3-羟基-2-氨基苯甲酸；NAD，烟酰胺腺嘌呤二核苷酸；TNA，色氨酸酶；ArAT，芳香族氨基酸转氨酶；IPYA，吲哚-3-丙酮酸；fldH，苯醛酸脱氢酶；ILA，吲哚乳酸；fldBC，苯乳酸脱水酶；IA，吲哚丙烯酸；IPA，吲哚丙酸；TMO，色氨酸2-单加氧酶；IAM，吲哚乙酰胺；IAA，吲哚-3-乙酸；IAld，吲哚-3-甲醛；IAAld，吲哚-3-乙醛；5-HTP，5-羟色氨酸；AAAD，芳香族氨基酸脱羧酶；AANAT，芳基烷基胺N-乙酰基转移酶；ASMT，乙酰血清素O-甲基转移酶；MAO，单胺类氧化酶；5-HIAA，5-羟基吲哚乙酸。

Figure 1. Tryptophan metabolism through the kynurenine, indole, and 5-HT pathways

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