恩替卡韦相关的中毒性表皮坏死松解症1例报告并文献复习

鲁瑞; 耿晓珍; 党双锁; 王文俊

doi:10.3969/j.issn.1001-5256.2022.06.027

恩替卡韦相关的中毒性表皮坏死松解症1例报告并文献复习

DOI: 10.3969/j.issn.1001-5256.2022.06.027

西安交通大学第二附属医院感染科，西安 710004

基金项目:

中国肝炎防治基金会-天晴肝病研究基金资助课题 (TQGB20180175)

伦理学声明：本例报告已获得患者知情同意。

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：鲁瑞负责个案资料的整理和论文初稿的撰写; 耿晓珍负责文献复习，参与个案资料的核对和论文讨论; 党双锁指导论文的写作; 王文俊负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
王文俊，wenjun_wang@xjtu.edu.cn

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出版历程
- 收稿日期: 2021-08-25
- 录用日期: 2021-09-26
- 出版日期: 2022-06-20

Toxic epidermal necrolysis related to entecavir: A case report and literature review

Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China

Research funding:

Chinese Foundation for Hepatitis Prevention and Control: TianQing Liver Disease Research Fund Subject (TQGB20180175)

More Information

Corresponding author: WANG Wenjun, wenjun_wang@xjtu.edu.cn(ORCID: 0000-0001-9861-1763)

摘要

- 恩替卡韦 /
- 表皮坏死松解症, 中毒性 /
- 乙型肝炎病毒
- Entecavir /
- Epidermal Necrolysis, Toxic /
- Hepatitis B virus

HTML全文

表 1 恩替卡韦相关皮肤不良反应的个案报道

Table 1. Case reports of cutaneous adverse reactions related to entecavir

作者和年份	国家	年龄(岁)	性别	皮疹类型	皮疹部位	暴露至发病时	DLST/ 斑贴试验/ 划痕试验	抗病毒药	治疗方法	皮疹结局
王丽君，2011^[3]	中国	39	男	TEN	颜面、躯干、四肢	7 d	未做	停恩替卡韦，换拉米夫定联合阿德福韦酯	糖皮质激素静脉滴注，抗组胺药口服	皮疹消退
Sugiura K，2009^[8]	日本	30	男	速发型皮肤过敏反应	臀部	2 d	划痕试验+ 斑贴试验-	停恩替卡韦，换拉米夫定	皮质类固醇外用，抗组胺药口服	皮疹消退
Yamada S，2011^[9]	日本	62	男	斑丘疹	躯干、四肢	7 d	DLST+	停恩替卡韦	皮质类固醇外用	皮疹消退
Yoon J，2013^[10]	韩国	65	女	肉芽肿	面部	2个月	斑贴试验-	停恩替卡韦	甲硝唑和防晒霜外用，米诺环素口服	二次服用恩替卡韦皮疹复发，停药及对症处理后皮疹完全消失
Taura M，2014^[11]	日本	65	男	红斑	双上肢	6个月	DLST+	恩替卡韦减量(0.5 mg隔日)	皮质类固醇外用	皮疹减轻，未完全消退
Kim J，2014^[12]	韩国	45	女	斑丘疹	背部、四肢	7 d	DLST+	停恩替卡韦，换拉米夫定联合阿德福韦酯	糖皮质激素和抗组胺药口服	皮疹消退
Temiz S，2018^[13]	土耳其	50	女	大疱型皮疹	右腿	7 d	未做	停恩替卡韦，换拉米夫定联合阿德福韦酯	皮质类固醇外用，抗组胺药口服	皮疹消退
Cheong X，2020^[14]	马来西亚	55	男	苔藓样红斑	躯干、四肢	6周	未做	停恩替卡韦，换富马酸丙酚替诺福韦	糖皮质激素口服，润肤霜外用	皮疹消退
本例	中国	26	男	TEN	颜面、躯干、四肢	1个月	未做	停恩替卡韦，换富马酸丙酚替诺福韦	血浆置换，静脉滴注人免疫球蛋白，糖皮质激素静脉滴注和口服，夫西地酸乳膏和复方黄柏液外用	皮疹消退

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参考文献(18)

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