急性胰腺炎胰酶异常活化和分泌的分子机制

崔恬玉; 刘瑞霞; 阴赪宏

doi:10.3969/j.issn.1001-5256.2022.05.047

急性胰腺炎胰酶异常活化和分泌的分子机制

DOI: 10.3969/j.issn.1001-5256.2022.05.047

a.
首都医科大学附属北京妇产医院内科，北京 100026
b.
首都医科大学附属北京妇产医院中心试验室，北京 100026

基金项目:

北京市教育委员会科技计划一般项目 (KM201910025007);

国家自然科学基金 (81571933)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：崔恬玉负责拟定写作思路，检索文献，撰写论文; 刘瑞霞、阴赪宏负责指导、修改论文并最终定稿。

详细信息

通信作者:
阴赪宏，yinchh@ccmu.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2021-08-31
- 录用日期: 2021-10-08
- 出版日期: 2022-05-20

Research advances in abnormal activation and secretion of pancreatic enzymes in acute pancreatitis

a.
Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
b.
Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China

Research funding:

Beijing Municipal Commission of Education (KM201910025007);

National Natural Science Foundation of China (81571933)

More Information

Corresponding author: YIN Chenghong, yinchh@ccmu.edu.cn(ORCID: 0000-0002-2503-3285)

摘要

摘要: 胰腺腺泡细胞内胰酶异常活化和分泌是急性胰腺炎(AP)的重要发病机制之一，可直接损伤胰腺组织加速疾病进程，诱发重症急性胰腺炎。目前临床抑制胰酶异常活化和分泌的药物效果欠佳，探寻新的治疗靶点十分重要。本文归纳了AP胰酶异常活化和分泌的病理事件(胞浆钙离子超载、溶酶体与酶原颗粒的共定位、细胞器损伤、胰酶顶端侧分泌受阻和基底侧分泌增加等)，搜集了相关事件的分子机制，讨论了胰酶异常活化和分泌在AP早期的作用过程，为未来靶向药物的研发提供思路。
- 胰腺炎 /
- 胰酶 /
- 分泌小泡
Abstract: Abnormal activation and secretion of pancreatic enzymes in pancreatic acinar cells is one of the important pathogeneses of acute pancreatitis (AP) and can directly damage the pancreatic tissue to accelerate disease progression and induce severe AP. At present, the drugs inhibiting the abnormal activation and secretion of pancreatic enzymes tend to have an unsatisfactory effect in clinical practice, and therefore, it is of great importance to search for new therapeutic targets. This article summarizes the pathological events of abnormal activation and secretion of pancreatic enzymes (cytoplasmic calcium overload, colocalization of lysosomes and zymogen granules, organelle injury, obstructed apical secretion of trypsin, and increased basal secretion of trypsin), collects the molecular mechanisms of related events, and discusses the role of abnormal activation and secretion of pancreatic enzymes in the early stage of AP, so as to provide ideas for the development of targeted drugs in the future.
- Pancreatitis /
- Pancreatin /
- Secretory Vesicles

HTML全文

图 1 VAMP8介导的顶端侧分泌受损和基底侧分泌增强示意图

Figure 1. Schematic illustration of VAMP8-mediated impaired apical secretion and enhanced basal secretion

下载: 全尺寸图片幻灯片

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