PM2.5在肝癌发生发展中的作用

左飞; 李国东; 刘明

doi:10.3969/j.issn.1001-5256.2022.04.038

PM2.5在肝癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2022.04.038

左飞¹,
李国东²,
刘明^1, , ,

1.
哈尔滨医科大学附属第二医院普外科，哈尔滨 150001
2.
哈尔滨医科大学附属第四医院普外科，哈尔滨 150001

基金项目:

哈尔滨市应用技术研究与开发项目(优秀学科带头人B类) (2017RAXXJ057);

黑龙江省自然科学基金-联合引导项目 (LH2020H066)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：左飞负责拟定写作思路，查找文献，撰写论文；李国东负责对文章的内容做批判性审阅；刘明参与指导撰写文章并最后定稿。

详细信息

通信作者:
刘明，mliu35@aliyun.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-08-20
- 录用日期: 2021-10-08
- 出版日期: 2022-04-20

Role of particulate matter 2.5 in the development and progression of liver cancer

Fei ZUO¹,
Guodong LI²,
Ming LIU^{1
, ,
,}

1.
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
2.
Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Research funding:

Harbin Applied Technology Research and Development Project (Excellent Discipline Leader Class B) (2017RAXXJ057);

Natural Science Foundation of Heilongjiang Province-Joint Guidance Project (LH2020H066)

More Information

Corresponding author: LIU Ming, mliu35@aliyun.com(ORCID: 0000-0001-1640-5892)

摘要

摘要: 平均空气动力学直径≤2.5 μm的颗粒物(PM2.5)作为大气颗粒物的主要成分之一，已经成为影响人们健康的重要因素，然而针对PM2.5与肝癌发生发展关系的研究相对较少。回顾了PM2.5与肝癌发病的流行病学研究，总结了PM2.5引起肝癌的相关机制，包括改变酶活性，影响基因表达，诱导内质网应激，引起肝脂肪变性和导致肝纤维化等，同时讨论了PM2.5暴露对肝癌预后的影响。
- 肝肿瘤 /
- 颗粒物 /
- 病理过程 /
- 预后
Abstract: Particulate matter 2.5 (PM2.5), as one of the main components of atmospheric particulate matter, has become an important factor affecting people's health; however, there are relatively few studies on the association of PM2.5 with the development and progression of liver cancer. This article reviews the epidemiological study of PM2.5 and liver cancer, summarizes the mechanisms of PM2.5 causing liver cancer (including changing enzyme activity, affecting gene expression, inducing endoplasmic mesh stress, causing liver fat degeneration, and leading to liver fibrosis), and discusses the influence of PM2.5 exposure on the prognosis of liver cancer.
- Liver Neoplasms /
- Particulate Matter /
- Pathologic Processes /
- Prognosis

HTML全文

图 1 PM2.5影响肝癌的机制示意图

注：IRS，胰岛素受体底物；AKT，蛋白激酶B；ATF-6，活化转录因子6；PERK, 蛋白激酶R样内质网激酶；IRE1，肌醇需求酶1；TRAF2，肿瘤坏死因子相关受体因子2；JNK，氨基末端激酶。

Figure 1. Schematic diagram of the mechanism of PM2.5 affecting liver cancer

下载: 全尺寸图片幻灯片

参考文献(38)

[1]	LOOMIS D, GROSSE Y, LAUBY-SECRETAN B, et al. The carcinogenicity of outdoor air pollution[J]. Lancet Oncol, 2013, 14(13): 1262-1263. DOI: 10.1016/s1470-2045(13)70487-x.
[2]	VILLANUEVA A. Hepatocellular carcinoma[J]. N Engl J Med, 2019, 380(15): 1450-1462. DOI: 10.1056/NEJMra1713263.
[3]	FORNER A, REIG M, BRUIX J. Hepatocellular carcinoma[J]. Lancet, 2018, 391(10127): 1301-1314. DOI: 10.1016/S0140-6736(18)30010-2.
[4]	YAN YC, WEN K, MAO K, et al. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma[J]. J Clin Hepatol, 2020, 36(10): 2167-2172. DOI: 10.3969/j.issn.1001-5256.2020.10.002. 颜永聪, 温凯, 毛凯, 等. HBV相关肝细胞癌的发生机制[J]. 临床肝胆病杂志, 2020, 36(10): 2167-2172. DOI: 10.3969/j.issn.1001-5256.2020.10.002.
[5]	YUE H, YUN Y, GAO R, et al. Winter polycyclic aromatic hydrocarbon-bound particulate matter from peri-urban north China promotes lung cancer cell metastasis[J]. Environ Sci Technol, 2015, 49(24): 14484-14493. DOI: 10.1021/es506280c.
[6]	KREYLING WG, HIRN S, MÖLLER W, et al. Air-blood barrier translocation of tracheally instilled gold nanoparticles inversely depends on particle size[J]. ACS Nano, 2014, 8(1): 222-233. DOI: 10.1021/nn403256v.
[7]	GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet, 2018, 392(10159): 1923-1994. DOI: 10.1016/S0140-6736(18)32225-6.
[8]	HONG Z, GUO Z, ZHANG R, et al. Airborne fine particulate matter induces oxidative stress and inflammation in human nasal epithelial cells[J]. Tohoku J Exp Med, 2016, 239(2): 117-125. DOI: 10.1620/tjem.239.117.
[9]	DENG X, RUI W, ZHANG F, et al. PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells[J]. Cell Biol Toxicol, 2013, 29(3): 143-157. DOI: 10.1007/s10565-013-9242-5.
[10]	VAN EEDEN SF, TAN WC, SUWA T, et al. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10))[J]. Am J Respir Crit Care Med, 2001, 164(5): 826-830. DOI: 10.1164/ajrccm.164.5.2010160.
[11]	ZHANG Y, WANG S, ZHU J, et al. Effect of atmospheric PM2.5 on expression levels of NF-κB genes and inflammatory cytokines regulated by NF-κB in human macrophage[J]. Inflammation, 2018, 41(3): 784-794. DOI: 10.1007/s10753-018-0732-8.
[12]	KAWANISHI M, FUJIKAWA Y, ISHII H, et al. Adduct formation and repair, and translesion DNA synthesis across the adducts in human cells exposed to 3-nitrobenzanthrone[J]. Mutat Res, 2013, 753(2): 93-100. DOI: 10.1016/j.mrgentox.2013.03.005.
[13]	MEHTA M, CHEN LC, GORDON T, et al. Particulate matter inhibits DNA repair and enhances mutagenesis[J]. Mutat Res, 2008, 657(2): 116-121. DOI: 10.1016/j.mrgentox.2008.08.015.
[14]	ZHOU Q, WANG L, CAO Z, et al. Dispersion of atmospheric fine particulate matters in simulated lung fluid and their effects on model cell membranes[J]. Sci Total Environ, 2016, 542(Pt A): 36-43. DOI: 10.1016/j.scitotenv.2015.10.083.
[15]	CONKLIN DJ. From lung to liver: How does airborne particulate matter trigger NASH and systemic insulin resistance?[J]. J Hepatol, 2013, 58(1): 8-10. DOI: 10.1016/j.jhep.2012.10.008.
[16]	PAN WC, WU CD, CHEN MJ, et al. Fine particle pollution, alanine transaminase, and liver cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV)[J]. J Natl Cancer Inst, 2016, 108(3): djv341. DOI: 10.1093/jnci/djv341.
[17]	PEDERSEN M, ANDERSEN ZJ, STAFOGGIA M, et al. Ambient air pollution and primary liver cancer incidence in four European cohorts within the ESCAPE project[J]. Environ Res, 2017, 154: 226-233. DOI: 10.1016/j.envres.2017.01.006.
[18]	DENG H, ECKEL SP, LIU L, et al. Particulate matter air pollution and liver cancer survival[J]. Int J Cancer, 2017, 141(4): 744-749. DOI: 10.1002/ijc.30779.
[19]	LEE CH, HSIEH SY, HUANG WH, et al. Association between ambient particulate matter 2.5 exposure and mortality in patients with hepatocellular carcinoma[J]. Int J Environ Res Public Health, 2019, 16(14): 2490. DOI: 10.3390/ijerph16142490.
[20]	ZHANG Q, LUO Q, YUAN X, et al. Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells[J]. Oncol Lett, 2017, 13(5): 3445-3450. DOI: 10.3892/ol.2017.5947.
[21]	CAVE M, APPANA S, PATEL M, et al. Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004[J]. Environ Health Perspect, 2010, 118(12): 1735-1742. DOI: 10.1289/ehp.1002720.
[22]	KIM KN, LEE H, KIM JH, et al. Physical activity- and alcohol-dependent association between air pollution exposure and elevated liver enzyme levels: An elderly panel study[J]. J Prev Med Public Health, 2015, 48(3): 151-169. DOI: 10.3961/jpmph.15.014.
[23]	LI R, ZHANG M, WANG Y, et al. Effects of sub-chronic exposure to atmospheric PM2.5 on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in the livers of rats[J]. Toxicol Res (Camb), 2018, 7(2): 271-282. DOI: 10.1039/c7tx00262a.
[24]	QIN SJ, LI BR, CAI Y, et al. The PM (2.5) of L02 liver cell cancer gene and the influence of apoptosis related gene expression[J]. Carcinog Teratogenesis Mutagen, 2020, 32(4): 281-285. https://www.cnki.com.cn/Article/CJFDTOTAL-ABJB202004006.htm 秦双建, 李柏茹, 蔡颖, 等. PM_(2.5)对L02肝细胞部分癌基因和凋亡相关基因表达的影响[J]. 癌变·畸变·突变, 2020, 32(4): 281-285. https://www.cnki.com.cn/Article/CJFDTOTAL-ABJB202004006.htm
[25]	ZHOU W, TIAN D, HE J, et al. Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation[J]. Oncotarget, 2016, 7(15): 20691-20703. DOI: 10.18632/oncotarget.7842.
[26]	VELASCO G. Endoplasmic reticulum stressed by pollution. Focus on "Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues"[J]. Am J Physiol Cell Physiol, 2010, 299(4): C727-C728. DOI: 10.1152/ajpcell.00271.2010.
[27]	HABERZETTL P, O'TOOLE TE, BHATNAGAR A, et al. Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress[J]. Environ Health Perspect, 2016, 124(12): 1830-1839. DOI: 10.1289/EHP212.
[28]	XU J, ZHANG W, LU Z, et al. Airborne PM2.5-induced hepatic insulin resistance by Nrf2/JNK-mediated signaling pathway[J]. Int J Environ Res Public Health, 2017, 14(7): 787. DOI: 10.3390/ijerph14070787.
[29]	TAN HH, FIEL MI, SUN Q, et al. Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease[J]. J Immunotoxicol, 2009, 6(4): 266-275. DOI: 10.1080/15476910903241704.
[30]	HU X, MAO DW, YA CY. Association between cancer-associated fibroblasts and liver cancer[J]. J Clin Hepatol, 2021, 37(2): 444-447. DOI: 10.3969/j.issn.1001-5256.2021.02.041. 胡晓, 毛德文, 牙程玉. 肿瘤相关成纤维细胞与肝癌的关系[J]. 临床肝胆病杂志, 2021, 37(2): 444-447. DOI: 10.3969/j.issn.1001-5256.2021.02.041.
[31]	AFFO S, YU LX, SCHWABE RF. The role of cancer-associated fibroblasts and fibrosis in liver cancer[J]. Annu Rev Pathol, 2017, 12: 153-186. DOI: 10.1146/annurev-pathol-052016-100322.
[32]	ZHENG Z, ZHANG X, WANG J, et al. Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models[J]. J Hepatol, 2015, 63(6): 1397-1404. DOI: 10.1016/j.jhep.2015.07.020.
[33]	QIU YN, WANG GH, ZHOU F, et al. PM2.5 induces liver fibrosis via triggering ROS-mediated mitophagy[J]. Ecotoxicol Environ Saf, 2019, 167: 178-187. DOI: 10.1016/j.ecoenv.2018.08.050.
[34]	JIN D, TAO J, LI D, et al. Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion[J]. Oncotarget, 2015, 6(32): 33523-33533. DOI: 10.18632/oncotarget.5590.
[35]	ZHANG H, LI Z. microRNA-16 via Twist1 inhibits EMT induced by PM2.5 exposure in human hepatocellular carcinoma[J]. Open Med (Wars), 2019, 14: 673-682. DOI: 10.1515/med-2019-0078.
[36]	YANG ZE, ZHAO JK, YU HY. Current research on the biological function of mesenchymal stem cell-derived exosome and its regulatory effect on tumor[J]. Clin J Med Offic, 2020, 48(11): 1386-1388. DOI: 10.16680/j.1671-3826.2020.11.47. 杨紫恩, 赵继凯, 于卉影. 间充质干细胞来源外泌体生物学功能及对肿瘤调控作用研究现状[J]. 临床军医杂志, 2020, 48(11): 1386-1388. DOI: 10.16680/j.1671-3826.2020.11.47.
[37]	LI YG, DENG TX, ZHAO KF, et al. Effects of stable overexpression of TFF1 on proliferation, invasion, migration and EMT of MHCC97H hepatic cancer cell[J]. Chin J Immunol, 2021, 37(14): 1733-1737. DOI: 10.3969/j.issn.1000-484X.2021.14.013. 李亚光, 邓同兴, 赵克芳, 等. 稳定过表达TFF1对MHCC97H细胞增殖、侵袭、转移及EMT发生的影响[J]. 中国免疫学杂志, 2021, 37(14): 1733-1737. DOI: 10.3969/j.issn.1000-484X.2021.14.013.
[38]	WU WL, WANG WY, YAO WQ, et al. Suppressive effects of microRNA-16 on the proliferation, invasion and metastasis of hepatocellular carcinoma cells[J]. Int J Mol Med, 2015, 36(6): 1713-1719. DOI: 10.3892/ijmm.2015.2379.