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抗-HAV-IgM阳性的自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征1例报告

何艳莎 刘华宝 宋翊 陈新瑜 饶春燕

引用本文:
Citation:

抗-HAV-IgM阳性的自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征1例报告

DOI: 10.3969/j.issn.1001-5256.2022.04.025
基金项目: 

重大疑难疾病(肝纤维化)中西医临床协作试点项目 (Department of Medicine, State Adminstration of Traditional Chinese Medicine(2018)No.3);

重庆市技术创新与应用发展专项重点项目 (cstc2019jscx-dxwtBX0023);

重庆市自然科学基金 (cstc2020jcyj-msxmX0630);

重庆卫生健康委员会、重庆市科学技术局联合中医药科研项目 (2019ZY3202)

化理学声明:本例报告已获得患者知情同意。
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:何艳莎、饶春燕负责课题设计,资料分析,撰写论文;何艳莎参与收集数据,修改论文;宋翊、陈新瑜、刘华宝负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    饶春燕,chunyanrao@126.com

A case of anti-HAV-IgM-positive AIH-PBC overlap syndrome

Research funding: 

Pilot Project of Clinical Coopetation of Traditional Chinese and Western Medicine in Major Difficult Diseases(Liver Fibrosis) (Department of Medicine, State Adminstration of Traditional Chinese Medicine(2018)No.3);

Special Key Projects of Technological innovation and Application Development in Chongqing (cstc2019jscx-dxwtBX0023);

Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0630);

Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau) (2019ZY3202)

More Information
  • 图  1  肝穿刺病理结果(HE染色,×200)

    注:a,汇管区明显扩大,较多淋巴细胞、中性粒细胞、浆细胞浸润,中重度界面炎,可见小胆管损伤及桥接坏死;b,胆管上皮CK19阳性,可见轻-中度细胆管增生;c,IgG阳性,25个/HPF。

    Figure  1.  Pathological results of liver puncture (hematoxylin-eosin staining, × 200)

  • [1] WU MC, LI MD. Practice of hepatology[M]. Beijing: People's Medical Publishing House, 2011: 228.

    吴孟超, 李梦东. 实用肝脏病学[M]. 北京: 人民卫生出版社, 2011: 228.
    [2] RUST C, BEUERS U. Overlap syndromes among autoimmune liver diseases[J]. World J Gastroenterol, 2008, 14(21): 3368-3373. DOI: 10.3748/wjg.14.3368.
    [3] BUNCHORNTAVAKUL C, REDDY KR. Diagnosis and management of overlap syndromes[J]. Clin Liver Dis, 2015, 19(1): 81-97. DOI: 10.1016/j.cld.2014.09.005.
    [4] SUN CY, MA X. An excerpt of EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary cholangitis(2017)[J]. J Clin Hepatol, 2017, 33(10): 1888-1894. DOI: 10.3969/j.issn.1001-5256.2017.10.008.

    孙春燕, 马雄. 《2017年欧洲肝病学会临床实践指南: 原发性胆汁性胆管炎的诊断和管理》摘译[J]. 临床肝胆病杂志, 2017, 33(10): 1888-1894. DOI: 10.3969/j.issn.1001-5256.2017.10.008.
    [5] TRAM J, LE BACCON-SOLLIER P, BOLLORÉ K, et al. RNA testing for the diagnosis of acute hepatitis A during the 2017 outbreak in France[J]. J Viral Hepat, 2020, 27(5): 540-543. DOI: 10.1111/jvh.13255.
    [6] LANDRY ML. Immunoglobulin M for acute infection: True or false?[J]. Clin Vaccine Immunol, 2016, 23(7): 540-545. DOI: 10.1128/CVI.00211-16.
    [7] DESBOIS D, GRANGEOT-KEROS L, ROQUEBERT B, et al. Usefulness of specific IgG avidity for diagnosis of hepatitis A infection[J]. Gastroenterol Clin Biol, 2005, 29(5): 573-576. DOI: 10.1016/s0399-8320(05)82132-3.
    [8] CHAZOUILLÈRES O, WENDUM D, SERFATY L, et al. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: Clinical features and response to therapy[J]. Hepatology, 1998, 28(2): 296-301. DOI: 10.1002/hep.510280203.
    [9] European Association for the Study of the Liver. EASL clinical practice guidelines: Management of cholestatic liver diseases[J]. J Hepatol, 2009, 51(2): 237-267. DOI: 10.1016/j.jhep.2009.04.009.
    [10] TANEJA S, KUMAR P, MITRA S, et al. Acute exacerbation to autoimmune hepatitis mimicking acute viral hepatitis-a case series and review of literature[J]. J Clin Exp Hepatol, 2018, 8(1): 98-103. DOI: 10.1016/j.jceh.2017.08.005.
    [11] ABE K, KANNO Y, OKAI K, et al. Centrilobular necrosis in acute presentation of Japanese patients with type 1 autoimmune hepatitis[J]. World J Hepatol, 2012, 4(9): 262-267. DOI: 10.4254/wjh.v4.i9.262.
    [12] OZASLAN E, EFE C, HEURGUÉ-BERLOT A, et al. Factors associated with response to therapy and outcome of patients with primary biliary cirrhosis with features of autoimmune hepatitis[J]. Clin Gastroenterol Hepatol, 2014, 12(5): 863-869. DOI: 10.1016/j.cgh.2013.09.021.
    [13] HEURGUÉ A, VITRY F, DIEBOLD MD, et al. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: A retrospective study of 115 cases of autoimmune liver disease[J]. Gastroenterol Clin Biol, 2007, 31(1): 17-25. DOI: 10.1016/s0399-8320(07)89323-7.
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  • 收稿日期:  2021-07-27
  • 出版日期:  2022-04-20
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