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病原感染在自身免疫性肝病发生发展中的作用

张海萍 闫惠平 陈德喜 马迎民

引用本文:
Citation:

病原感染在自身免疫性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2022.04.004
基金项目: 

北京市属医学科研院所公益发展改革试点项目 (Jingyiyan 2021-10)

首都医科大学附属北京佑安医院2021年院内中青年人才孵育项目(青年创新类) (YNKTQN2021004)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张海萍负责收集资料分析并撰写论文;闫惠平负责写作设计、思路指导及论文修改并最后定稿;陈德喜和马迎民负责论文审阅。
详细信息
    通信作者:

    闫惠平,yhp503@126.com

The role of pathogen infections in the development and progression of autoimmune liver diseases

Research funding: 

Pilot Project of Public Welfare Development and Reform of Beijing Municipal Medical Research Institutes (Jingyiyan 2021-10);

Young and Middle-aged Talent Incubation Project in the Hospital of Beijing YouAn Hospital, Capital Medical University, 2021 (Youth Innovation) (YNKTQN2021004)

More Information
    Corresponding author: YAN Huipng, yhp503@126.com(ORCID: 0000-0002-1787-0067)
  • 摘要: 自身免疫性肝病(AILD)的病因和发病机制研究一直是领域内的研究热点。病原体感染可参与诱发机体的自身免疫反应,常常成为免疫性疾病的关键致病因素。本文基于文献数据和作者临床经验,将从分子模拟机制等方面对病原感染在AILD的发生和发展中的作用及其影响进行简单介绍,以助更深入地了解AILD的发病机制。

     

  • 表  1  人PDC-E2 155-1851*的分子模拟和免疫优势表位

    Table  1.   Molecular mimicry and immunodominant epitopes of human PDC-E2 155-1851*

    人类PDC-E2 KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
    B淋巴细胞 KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
    CD4+T淋巴细胞 KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
    CD8+T淋巴细胞 KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
    E. coli PDC-E2 2** K-G-----L-EIETDK-----G-
    Novosphingobium aromaticivorans -----GD-LAEIETDKAT--FE---EG-
    PDC-E2
    注: *K为硫辛酸的附着位点173lysine(赖氮酸);横线部分为每种细胞识别的表位;* * ExDK序列存在于人源和大肠杆菌PDC-E2中。
    下载: 导出CSV
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  • 收稿日期:  2022-01-04
  • 录用日期:  2022-02-17
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