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MAPK信号通路——肝棘球蚴病治疗新靶点

董琳琳 芦永良 鄂维建 张翔 赵玲莉

引用本文:
Citation:

MAPK信号通路——肝棘球蚴病治疗新靶点

DOI: 10.3969/j.issn.1001-5256.2022.03.045
基金项目: 

青海省科技基础研究计划项目 (2018-ZJ-757)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:董琳琳负责课题设计,资料分析,撰写论文;芦永良、鄂维建、张翔参与收集资料,修改论文;赵玲莉负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    赵玲莉,zhaolingli640521@163.com

The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis

Research funding: 

Qinghai Science And Technology Basic Research Program (2018-ZJ-757)

More Information
  • 摘要: MAPK信号通路可介导多种细胞因子参与炎症、癌症、免疫紊乱和神经退行性疾病等过程,其在肝棘球蚴病发生发展过程中也发挥重要作用。本文回顾了MAPK信号通路的结构及调节过程,重点阐述了肝棘球蚴病中MAPK信号通路的作用,即MAPK信号通路在肝棘球蚴病中存在虫体与宿主的双重激活,参与了疾病的发生、发展过程,并对其治疗产生影响,以MAPK信号通路为靶点的药物治疗有望成为肝棘球蚴病治疗新的策略。

     

  • 图  1  MAPK信号通路示意图

    表  1  目前已在棘球蚴中鉴定的相关MAPK基因、蛋白质及其功能

    棘球蚴类别 基因 蛋白质 功能 参考文献
    多房棘球蚴 EmRas EmRas 小GTP家族;Ras家族 [25]
    EmRal EmRal 小GTP家族;Ras家族 [34]
    EmRaf EmRaf MAPKKK,Raf家族 [25]
    EmMKK2 EmMKK2 MAPKK,MEK1/2家族 [27]
    EmMPK1 EmMPK1 MAPK,ERK家族 [26]
    EmMKK1 EmMKK1 MAPKK,MEK3/6家族 [27]
    EmMPK2 EmMPK2 MAPK,P38家族 [28]
    EmMPK3 EmMPK3 MAPK,JUK家族 [35]
    细粒棘球蚴 EgRas EgRas 小GTP家族;Ras家族 [29]
    EgRal EgRal 小GTP家族;Ras家族 [30]
    EgRaf EgRaf MAPKKK,Raf家族 [32]
    EgMKK2 EgMKK2 MAPKK,MEK1/2家族 [32]
    EgERK1 EgERK1 MAPK,ERK家族 [31]
    EgMKK 1 EgMKK1 MAPKK,MEK3/6家族 [32]
    EgP38 EgP38 MAPK,P38家族 [33]
    下载: 导出CSV
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