胆固醇与肝再生关系及其在肝衰竭治疗中的意义和潜在价值

林镛; 颜耿杰; 冯逢; 彭子明; 龙富立; 韦艾凌; 王明刚; 姚春

doi:10.3969/j.issn.1001-5256.2022.03.044

胆固醇与肝再生关系及其在肝衰竭治疗中的意义和潜在价值

DOI: 10.3969/j.issn.1001-5256.2022.03.044

林镛¹,
颜耿杰¹,
冯逢¹,
彭子明¹,
龙富立^{1, 2},
韦艾凌²,
王明刚²,
姚春^3, , ,

1.
广西中医药大学研究生院，南宁 530200
2.
广西中医药大学第一附属医院肝病二区，南宁 530023
3.
广西中医药大学，南宁 530000

基金项目:

国家自然科学基金 (81704021);

国家自然科学基金 (81760844);

国家自然科学基金 (8170150729);

国家科技重大专项 (2018ZX10725505-001-011);

广西科技计划项目 (2020GXNSFAA297098);

广西中医药大学校级硕士研究生创新项目 (YCXJ2021034)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：林镛负责课题设计，资料分析，撰写论文；颜耿杰、冯逢、彭子明、韦艾凌、龙富立参与收集数据，修改论文；王明刚、姚春负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
姚春，1197840425@qq.com

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出版历程
- 收稿日期: 2021-07-13
- 录用日期: 2021-08-13
- 出版日期: 2022-03-20

Association between cholesterol and liver regeneration and its significance and potential value in clinical treatment of liver failure

1.
Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China
2.
Second Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
3.
Guangxi University of Chinese Medicine, Nanning 530000, China

Research funding:

National Natural Science Foundation of China (81704021);

National Natural Science Foundation of China (81760844);

National Natural Science Foundation of China (8170150729);

National Major Science Technology Project (2018ZX10725505-001-011);

Guangxi Science and Technology Plan Project (2020GXNSFAA297098);

Postgraduate Innovation Project of Guangxi University of Chinese Medicine (YCXJ2021034)

More Information

Corresponding author: YAO Chun, 1197840425@qq.com(ORCID: 0000-0002-6612-874X)

摘要

摘要: 肝衰竭为临床上常见的严重肝病症候群，属内科危急重症之一。其病理学是以大面积肝细胞死亡为特征，核心机制是内毒素、免疫反应和炎症级联反应等。肝细胞有效再生以代偿肝功能是促进肝衰竭良好转归的生理基础，并直接影响肝衰竭患者的预后和生存质量。临床实践中已发现血清胆固醇水平低的肝衰竭患者病死率极高，但胆固醇作为肝细胞合成代谢指标，其与肝细胞再生的关系并未引起足够的重视。本文从胆固醇与肝再生关系出发，综述其在肝衰竭临床治疗中的意义和潜在价值，以期从另一角度了解肝衰竭的发病机制，为肝衰竭的诊疗、药物研发提供新思路。
- 肝功能衰竭 /
- 胆固醇 /
- 肝再生
Abstract: Liver failure is a common severe liver disease syndrome in clinical practice and is one of the critical medical conditions in internal medicine. Massive hepatocyte death is the main pathological feature of liver failure, and its core mechanisms include endotoxin, immune response, and inflammatory cascade reaction. Effective regeneration of hepatocytes to compensate liver function is the physiological basis for promoting the good prognosis of liver failure, which directly affects the prognosis and quality of life of patients with liver failure. It has been found in clinical practice that liver failure patients with a low serum level of cholesterol tend to have an extremely high mortality rate, but as an index of hepatocyte anabolism, the association between cholesterol and hepatocyte regeneration has not been taken seriously. Based on the association between cholesterol and liver regeneration, this article reviews its significance and potential value in the clinical treatment of liver failure, in order to understand the pathogenesis of liver failure from another perspective and provide new ideas for the diagnosis and treatment of liver failure and the development of drugs.
- Liver Failure /
- Cholesterol /
- Liver Regeneration

HTML全文

图 1 影响肝脏再生的相关分子及反应过程

注：FGF，成纤维细胞生长因子；YAP、GPC-3为靶点蛋白；LtxB，P450单加氧酶。

下载: 全尺寸图片幻灯片

图 2 胆固醇-胆汁酸的代谢循环

注：SHP，小异二聚体伴侣；CYP8B1，胆固醇12α-羟化酶；BSEP，胆盐输出泵；ABCB4，胆汁酸合成基因；FGFR，成纤维细胞生长因子受体。

下载: 全尺寸图片幻灯片

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