缺氧诱导因子对肝细胞癌的作用机制及临床意义

李宏一; 罗业浩; 罗筱凡; 吴笛; 秦黄冠; 蓝绍航; 吕挺; 庞宇舟

doi:10.3969/j.issn.1001-5256.2022.03.040

缺氧诱导因子对肝细胞癌的作用机制及临床意义

DOI: 10.3969/j.issn.1001-5256.2022.03.040

1.
广西中医药大学，广西壮医应用基础研究重点实验室，南宁 530200
2.
湖北民族大学医学部，湖北恩施 445000

基金项目:

广西医学高层次骨干人才培养‘139’计划资助项目 (GWKJF〔2020〕No.15);

广西壮族自治区卫生健康委员会壮医应用基础研究重点实验室项目 (GWKJF〔2020〕No.17);

广西中医药大学“岐黄工程”高层次人才团队培育项目 (2021003);

中医学广西一流学科 (GJKS〔2018〕No.12)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李宏一负责课题设计、资料分析及撰写论文；罗筱凡、吴笛、秦黄冠负责文献检索及资料整理；蓝绍航、吕挺参与收集数据及修改论文；庞宇舟、罗业浩负责选题、拟定写作思路，并最后定稿。

详细信息

通信作者:
庞宇舟，pangyz422@sina.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-07-22
- 录用日期: 2021-08-12
- 出版日期: 2022-03-20

Mechanism of action and clinical significance of hypoxia-inducible factors in hepatocellular carcinoma

1.
Key Laboratory of Applied Basic Research of Guangxi Zhuang Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
2.
Department of Medicine, Hubei Minzu University, Enshi, Hubei 445000, China

Research funding:

Guangxi Medical High Level Backbone Personnel Training "139" Program Funding Project (GWKJF〔2020〕No.15);

Key Laboratory of Applied Basic Research of Zhuang Medicine of Guangxi Health Committee (Guangxi University of traditional Chinese Medicine) (GWKJF〔2020〕No.17);

"Qi Huang Project" High Level Talent Team Cultivation Project of Guangxi University of Traditional Chinese Medicine (2021003);

Guangxi First Class Discipline of Traditional Chinese Medicine (GJKS〔2018〕No.12)

More Information

Corresponding author: PANG Yuzhou, pangyz422@sina.com(ORCID: 0000-0003-4410-5050)

摘要

摘要: 由于肿瘤细胞快速增殖生长，许多实体瘤中存在缺氧的微环境，缺氧诱导因子对于感知肿瘤内的氧张力并随后介导缺氧反应激活至关重要。肝细胞癌(HCC)是最缺氧的肿瘤之一，本文总结了缺氧诱导因子通过促进糖酵解、血管生成、侵袭转移、免疫逃避、癌症干细胞化等方式促进HCC发生发展的作用机制。当前，缺氧诱导因子抑制剂靶向药物的研发在HCC治疗领域具有广阔前景，缺氧诱导因子检测对HCC预后评估也具有潜在价值。
- 癌，肝细胞 /
- 缺氧诱导因子 /
- 分子靶向治疗 /
- 预后
Abstract: Due to the rapid proliferation and growth of tumor cells, hypoxic microenvironment exists in many solid tumors, and hypoxia inducible factors (HIF) are critical for sensing oxygen tension within tumors and subsequently mediating the activation of hypoxia responses. Hepatocellular carcinoma (HCC) is one of the most hypoxic tumors. This article summarizes the mechanism of action of HIF in promoting the development and progression of HCC by promoting glycolysis, angiogenesis, invasion and metastasis, immune escape, and cancer stem cell formation. At present, the development of targeted drugs for HIF inhibitors has broad prospects in the treatment of HCC, and the detection of HIF also has a potential value in prognostic evaluation HCC.
- Carcinoma, Hepatocellular /
- Hypoxia-Inducible Factor /
- Molecular Targeted Therapy /
- Prognosis

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图 1 HIF作用于HCC的作用机制示意图

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