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槐耳制剂辅助治疗肝细胞癌的作用机制及其临床应用进展

谢铠岭 徐锋

引用本文:
Citation:

槐耳制剂辅助治疗肝细胞癌的作用机制及其临床应用进展

DOI: 10.3969/j.issn.1001-5256.2022.03.038
基金项目: 

辽宁省自然科学基金 (20180551193)

辽宁省自然科学基金 (2020-MS-181)

盛京医院345人才工程计划 (40B)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:谢铠岭负责文献查找与整理,撰写文章;徐锋负责拟定写作思路,提供意见,修改文章并最终定稿。
详细信息
    通信作者:

    徐锋,xufengsjh@126.com

Mechanism of action of Huaier granules in treatment of hepatocellular carcinoma and advances in its clinical application

Research funding: 

Natural Science Foundation of Liaoning Province (20180551193);

Natural Science Foundation of Liaoning Province (2020-MS-181);

345 Talent Project of Shengjing Hospital (40B)

More Information
  • 摘要: 肝细胞癌(HCC)是我国第二大疾病相关死亡原因,严重威胁着居民健康。近年研究证明中医药在HCC综合治疗中发挥了重要作用。槐耳制剂现已被推荐用于HCC的治疗,其作用机制包括抑制血管生成、抑制HCC细胞增殖、抑制侵袭与转移、诱导细胞凋亡、调节免疫功能等。本文总结了槐耳抗HCC机理研究和槐耳颗粒在临床中的应用进展,以期为后续研究和临床治疗提供参考。

     

  • 图  1  槐耳抗HCC作用机制

    注:TLR4,Toll样受体4;N-cadherin,钙黏蛋白N;E-cadherin,钙黏蛋白E;LaminB1,核纤层蛋白;NOV,肾母细胞过表达基因;MAPK,丝裂原活化蛋白激酶;JNK,c-Jun氨基末端激酶;ERK,细胞外调节蛋白激酶;PI3K,磷脂酰肌醇激酶;AKT,丝/苏氨酸蛋白激酶;AEG-1 shRNA,星形胶质细胞提高基因短发夹RNA;CDK,细胞周期蛋白依赖性激酶;Cyclin,细胞周期调节蛋白;NO,一氧化氮;IL-6,白细胞介素6;COX-2,环氧化酶-2;TNFα,肿瘤坏死因子α;Bcl-2,B淋巴细胞瘤-2基因;BAX,Bcl-2基因家族中的一员;G1、S、G2、M,细胞周期4个阶段;Cry61,半胱氨酸蛋白61;CTGF,结缔组织生长因子;Runx2,Runx2家族转录因子2;TEAD2,转录增强缔合域蛋白2;OXA,奥沙利铂。

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