肝胆肿瘤模型与精准药物筛选新技术

刘壮; 高栋

doi:10.3969/j.issn.1001-5256.2022.03.005

肝胆肿瘤模型与精准药物筛选新技术

DOI: 10.3969/j.issn.1001-5256.2022.03.005

刘壮,
高栋^, ,

细胞生物学国家重点实验室，上海市分子男科学重点实验室，中国科学院分子细胞科学卓越创新中心，上海 200031

基金项目:

国家重点研发计划 (2017YFA0505500);

中国科学院A类战略性先导科技专项 (XDA16020905);

中国科学院A类战略性先导科技专项 (XDB19000000);

国家自然科学基金 (81830054);

国家自然科学基金 (81772723);

国家科技重大专项课题项目 (2018ZX10302207-004-002)

利益冲突声明: 所有作者均声明不存在利益冲突。

作者贡献声明: 刘壮负责撰写论文，文献筛选，整理数据和修改论文; 高栋负责拟定写作思路，指导撰写论文及并最终定稿。

详细信息

通信作者:
高栋，dong.gao@sibcb.ac.cn

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出版历程
- 收稿日期: 2022-01-04
- 录用日期: 2022-01-14
- 出版日期: 2022-03-20

Hepatobiliary tumor models and novel technology for accurate drug screening

Zhuang LIU,
Dong GAO^{,
,}

State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China

Research funding:

Grants from the National Key Research and Development Program of China (2017YFA0505500);

The Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16020905);

The Strategic Priority Research Program of the Chinese Academy of Sciences (XDB19000000);

The National Natural Science Foundation of China (81830054);

The National Natural Science Foundation of China (81772723);

The State Key Project for Infectious Diseases (2018ZX10302207-004-002)

More Information

Corresponding author: GAO Dong, dong.gao@sibcb.ac.cn(ORCID: 0000-0003-1821-2741)

摘要

摘要: 肝胆肿瘤是包括原发性肝癌、胆管癌和胆囊癌在内的恶性肿瘤。目前，肝胆肿瘤已成为世界范围内癌症相关死亡的第二大病因，而对于肝胆肿瘤的治疗手段仍无法有效应对临床需求。因此，探索开发肝胆肿瘤精准药物筛选的实验技术，寻找临床治疗新策略新方法，为早期诊断和综合治疗提供新思路，是当前领域内的关键问题。本文主要围绕肝胆肿瘤个性化病理模型的构建及药物筛选方案，特异靶点药物的设计与筛选策略，基于人工智能和大数据分析的药物筛选策略等方面介绍肝胆肿瘤精准药物筛选新技术的最新研究进展，探讨其应用潜力，并展望未来发展方向。
- 肝肿瘤 /
- 胆道肿瘤 /
- 人工智能 /
- 药物筛选试验, 抗肿瘤
Abstract: Hepatobiliary tumor is a type of malignant tumor including primary liver cancer, cholangiocarcinoma, and gallbladder carcinoma. At present, hepatobiliary tumors have become the second leading cause of cancer-related death worldwide, while the treatment methods for such tumors cannot effectively meet clinical needs. Therefore, it is a key scientific problem in this field to explore and develop the experimental technology of accurate drug screening for hepatobiliary tumors, find new strategies and methods for clinical treatment, and provide new ideas for early diagnosis and comprehensive treatment of hepatobiliary tumors. This article introduces the latest research advances in the novel technologies for accurate drug screening for hepatobiliary tumor and their application potential by focusing on the construction of individualized pathological models of hepatobiliary tumor, drug screening technologies, the design and screening strategy of specific target drugs, and drug screening strategy based on artificial intelligence and big data analysis, as well as the directions for future development.
- Liver Neoplasm /
- Biliary Tract Tumor /
- Artificial Intelligence /
- Drug Screening Assays, Antitumor

HTML全文

表 1 肝胆肿瘤模型与精准药物筛选新技术

分类	优点	缺点
移植瘤模型	可以有效反映患者组织的状态并进行药物效果检测^[8-10]	需要的肿瘤组织多，成本较高
类器官模型	体外模拟肿瘤细胞的培养模型，可以进行大规模高通量的药物筛选实验^[31-33]	缺乏肿瘤微环境的细胞，异质性未被充分验证
分子靶向治疗	针对患者的特异性位点进行靶向治疗，副作用小^[38-41]	患者的基因突变情况复杂多样，会产生耐药性
人工智能及药物预测	基于药物响应数据和患者信息，计算机技术等辅助临床治疗^[49-51]	数据库信息不全面，技术有待发展

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