中医药成分防治肝缺血再灌注损伤的研究进展

李振; 曾意豪; 王科; 王凯强; 俞科贤

doi:10.3969/j.issn.1001-5256.2022.02.044

中医药成分防治肝缺血再灌注损伤的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.02.044

李振^1a,
曾意豪²,
王科^1a,
王凯强^1a,
俞科贤^1b, ,

1a.
青海大学研究生院，西宁 810016
1b.
青海大学医学院，西宁 810016
2.
广州仁爱天河医院康复一科，广州 510630

基金项目:

国家中医药管理局——全国中医药创新骨干人才培训项目 (Guozhongyiyao Renjiaohan [2019]No.128)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李振负责课题设计，资料分析，撰写论文；李振、曾意豪、王科、王凯强参与收集数据，修改论文；俞科贤、李振负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
俞科贤, ykx0421@163.com

李振、曾意豪、王科同为第一作者

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- 文章访问数: 449
- HTML全文浏览量: 155
- PDF下载量: 44
- 被引次数: 0
出版历程
- 收稿日期: 2021-07-03
- 录用日期: 2021-08-10
- 出版日期: 2022-02-20

Research advances in the prevention and treatment of hepatic ischemia-reperfusion injury with traditional Chinese medicine components

Zhen LI^1a,
Yihao ZENG²,
Ke WANG^1a,
Kaiqiang WANG^1a,
Kexian YU^{1b
, ,}

1a.
Graduate School, Qinghai University, Xining 810016, China
1b.
Medical College, Qinghai University, Xining 810016, China
2.
First Department of Rehabilitation, Guangzhou Renai Tianhe Hospital, Guangzhou 510630, China

Research funding:

State Administration of Traditional Chinese Medicine—National Training Program for Innovative Backbone Talents of Traditional Chinese Medicine (Guozhongyiyao Renjiaohan [2019]No.128)

More Information

Corresponding author: YU Kexian, ykx0421@163.com

摘要

摘要: 肝缺血再灌注损伤(HIRI)是肝移植、肝脏切除及休克等疾病的一种极为常见的并发症。目前对于HIRI的研究较多，但临床仍缺乏根治性的药物。相关细胞、分子机制及通路、活性氧及氧化应激反应、一氧化氮及线粒体等多种因素介导了HIRI的发生和发展，这不仅导致患者生活质量降低，且危及患者生命安全。在HIRI发生机制的基础上结合相关文献，总结中医药成分防治HIRI的研究进展，旨在为HIRI的基础实验及临床研究提供理论支持。
- 肝疾病 /
- 再灌注损伤 /
- 中草药 /
- 治疗学
Abstract: Hepatic ischemia-reperfusion injury (HIRI) is a very common complication of liver transplantation, liver resection, and shock. At present, many studies have been conducted on HIRI, but there is still a lack of drugs for radical treatment in clinical practice. Many factors, such as related cells, molecular mechanisms and signaling pathways, reactive oxygen species and oxidative stress response, nitric oxide, and mitochondria, mediate the development and progression of HIRI, which leads to the decline of patients' quality of life and even endangers their life safety. Based on the pathogenesis of HIRI and related articles, this article summarizes the research advances in the prevention and treatment of HIRI with traditional Chinese medicine components, so as to provide theoretical support for basic research and clinical research on HIRI.
- Liver Diseases /
- Reperfusion Injury /
- Drugs, Chinese Herbal /
- Therapeutics

HTML全文

图 1 HIRI的病理机制

下载: 全尺寸图片幻灯片

图 2 中医药防治HIRI的药理作用及其相关机制

下载: 全尺寸图片幻灯片

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