鞘磷脂酶在肝细胞癌中的作用

姚春; 张广发; 乐滢玉; 毛德文; 张荣臻; 刘茵

doi:10.3969/j.issn.1001-5256.2022.02.042

鞘磷脂酶在肝细胞癌中的作用

DOI: 10.3969/j.issn.1001-5256.2022.02.042

1.
广西中医药大学研究生院，南宁 530222
2.
广西中医药大学第一附属医院肝病一区，南宁 530023

基金项目:

国家自然科学基金面上项目 (81774236);

国家自然科学基金项目 (81960841)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：姚春、张广发负责拟定写作思路，撰写文章；毛德文负责研究选题，指导文章撰写和修改；张荣臻、刘茵负责设计论文框架；乐滢玉负责起草论文。

详细信息

通信作者:
毛德文, mdwboshi2005@163.com

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- PDF下载量: 50
- 被引次数: 0
出版历程
- 收稿日期: 2021-06-29
- 录用日期: 2021-07-30
- 出版日期: 2022-02-20

Role of sphingomyelinases in hepatocellular carcinoma

1.
Graduate School, Guangxi University of Chinese Medicine, Nanning 530222, China
2.
First Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

General Project of National Natural Science Foundation of China (81774236);

National Natural Science Foundation of China (81960841)

More Information

Corresponding author: MAO Dewen, mdwboshi2005@163.com

摘要

摘要: 鞘磷脂酶(SMase)是调节鞘磷脂类信号通路及其相关产物代谢的主要酶类，参与了鞘磷脂复杂代谢过程中的关键步骤。近年来，许多研究表明SMase参与了细胞周期停滞、细胞迁移和炎症等生物学过程，并通过调节肿瘤干细胞的凋亡和增殖来促进肝细胞癌的发生发展。SMase在肝细胞癌的发生发展及诊疗中具有重要潜在生物学价值。就SMase在肝细胞癌发生发展中的作用进行归纳和探讨，以期为其临床治疗和新型药物的开发提供新的思路和策略。
- 癌, 肝细胞 /
- 鞘脂类 /
- 神经酰胺类
Abstract: Sphingomyelinases (SMase) are the main enzymes that regulate the signaling pathway of sphingomyelin and the metabolism of related products, and they are involved in the key steps of the complex metabolic process of sphingomyelin. In recent years, many studies have shown that SMase is involved in the biological processes such as cell cycle arrest, cell migration, and inflammation and promotes the development and progression of hepatocellular carcinoma by regulating the apoptosis and proliferation of tumor stem cells. SMase has an important potential biological value in the development, progression, diagnosis, and treatment of hepatocellular carcinoma. This article summarizes the exact role of SMase in the development and progression of hepatocellular carcinoma, in order to provide new ideas and strategies for the clinical treatment of hepatocellular carcinoma and the development of new drugs.
- Carcinoma, Hepatocellular /
- Sphingolipids /
- Ceramides

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参考文献(49)

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