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Wnt信号通路与肝纤维化的关系

范钦 李红俊 李晓霞 杨尹 陈海燕 成家茂

引用本文:
Citation:

Wnt信号通路与肝纤维化的关系

DOI: 10.3969/j.issn.1001-5256.2022.02.038
基金项目: 

2021年云南省地方本科高校基础研究联合专项资金面上项目 (202101BA070001-101)

2022年云南省教育厅科学研究基金 (2022Y809)

2021年云南省教育厅科学研究基金 (2021J0382)

2017年度云南省自然科学基金高校联合基金 (2017FH001-076)

云南省李云庆专家工作站项目 (202005AF150014)

大理大学神经生物学创新团队项目 (ZKLX2019108)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:范钦、李红俊、李晓霞、杨尹负责查找文献,资料分析,撰写论文;成家茂、陈海燕负责拟定写作框架,指导思路并修改稿件和最后定稿。
详细信息
    通信作者:

    陈海燕, 316573230@qq.com

    成家茂, chjmao@163.com

Association between the Wnt signaling pathway and hepatic fibrosis

Research funding: 

General Project of Special Joint Fund for the Basic Research of Local Undergraduate Colleges and Universities in Yunnan Province in 2021 (202101BA070001-101);

The 2022 Scientific Research Fund of the Education Department of Yunnan Province (2022Y809);

The 2021 Scientific Research Fund of the Education Department of Yunnan Province (2021J0382);

The 2017 Joint University Fund of Natural Science Foundation of Yunnan Province (2017FH001-076);

Project of Li Yunqing Expert Workstation of Yunnan Province (202005AF150014);

Innovation Team of Neurobiology of Dali University (ZKLX2019108)

More Information
  • 摘要: 在各种慢性肝损伤后,肝纤维化是生物体的一种自我修复性病理过程,并能引起肝硬化、肝癌等疾病。Wnt信号通路广泛存在于无脊椎动物和脊椎动物中,是一类在物种进化过程中高度保守的信号通路。许多研究已经证实Wnt信号通路与肝纤维化的发生发展有密切联系。主要从经典和非经典Wnt信号通路调控肝星状细胞、肝巨噬细胞、肝祖细胞的机制方面进行概述,为后续深入开展Wnt信号调控肝纤维化机制研究及探索可逆转肝纤维化的治疗靶点提供新思路。

     

  • 图  1  Wnt信号通路的经典途径和非经典途径[3-4]

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  • 收稿日期:  2021-07-05
  • 录用日期:  2021-08-11
  • 出版日期:  2022-02-20
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