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原发性肝癌诊疗指南(2022年版)

国家卫生健康委办公厅

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原发性肝癌诊疗指南(2022年版)

DOI: 10.3969/j.issn.1001-5256.2022.02.009

Standard for diagnosis and treatment of primary liver cancer (2022 edition)

  • 图  1  肝脏肿瘤标本基线取材部位示意图

    注:A、B、C、D,分别对应肿瘤时钟位12点、3点、6点和9点的癌与癌旁肝组织交界处;E,肿瘤区域;F,近癌旁肝组织区域;G,远癌旁肝组织区域。

    图  2  肝癌诊断路线图

    注:典型表现——动脉期(主要动脉晚期)病灶明显强化,门静脉和/或延迟期强化下降,呈“快进快出”强化方式;不典型表现——缺乏动脉期病灶强化或门静脉和延迟期强化没有下降或下降不明显,甚至强化稍有增加等。US,超声检查;MRI,多参数MRI;CT,CT动态增强扫描;CEUS,超声造影,使用超声对比剂实时观察正常组织和病变组织的血流灌注情况;EOB-MRI,肝细胞特异性对比剂钆塞酸二钠(Gd-EOB-DTPA)增强磁共振扫描;AFP(+),超过血清AFP检测正常值。

    图  3  中国肝癌临床分期与治疗路线图

    注:系统抗肿瘤治疗包括①一线治疗,阿替利珠单抗+贝伐单抗、信迪利单抗+贝伐单抗类似物;多纳非尼、仑伐替尼、索拉非尼;FOLFOX4。②二线治疗,瑞戈非尼、阿帕替尼、卡瑞利珠单抗、替雷利珠单抗。

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