中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制

张腊英 陈明锴

引用本文:
Citation:

瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制

DOI: 10.3969/j.issn.1001-5256.2022.01.040
基金项目: 

湖北省重点研发项目 (2020BCB007)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张腊英对研究的思路或设计有关键贡献;陈明锴负责修改论文中的关键性部分。
详细信息
    通信作者:

    陈明锴,kaimingchen@163.com

Research advances in the mechanism of action of TRPV4 ion channel protein in liver diseases

Research funding: 

The Key Project of Hubei Province (2020BCB007)

  • 摘要: 瞬时感受器电位离子通道蛋白V4 (TRPV4)属于瞬时感受器电位离子通道家族中的一员,是一种非选择性阳离子通道,其广泛分布在多种组织及器官中。近年来越来越多的研究介绍了TRPV4通道蛋白与肝纤维化、肝癌、多囊性肝病等肝脏疾病的密切关系。本文主要对TRPV4与肝脏疾病的有关文献进行分析,归纳总结TRPV4与肝脏疾病之间确切的信号通路及可能的潜在机制,以期临床应用及进一步研究。

     

  • [1] COSENS D J, MANNING A. Abnormal electroretinogram from a Drosophila mutant[J]. Nature, 1969, 224(5216): 285-287. DOI: 10.1038/224285a0.
    [2] TOFT-BERTELSEN TL, MACAULAY N. TRPing to the point of clarity: Understanding the function of the complex TRPV4 ion channel[J]. Cells, 2021, 10(1): 165. DOI: 10.3390/cells10010165.
    [3] ZHAN L, LI J. The role of TRPV4 in fibrosis[J]. Gene, 2018, 642: 1-8. DOI: 10.1016/j.gene.2017.10.067.
    [4] FANG Y, LIU G, XIE C, et al. Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway[J]. Biomed Pharmacother, 2018, 101: 910-919. DOI: 10.1016/j.biopha.2018.03.014.
    [5] GRADILONE SA, MASYUK TV, HUANG BQ, et al. Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD[J]. Gastroenterology, 2010, 139(1): 304-314. e2. DOI: 10.1053/j.gastro.2010.04.010.
    [6] WATANABE H, DAVIS JB, SMART D, et al. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives[J]. J Biol Chem, 2002, 277(16): 13569-13577. DOI: 10.1074/jbc.M200062200.
    [7] VENKATACHALAM K, MONTELL C. TRP channels[J]. Annu Rev Biochem, 2007, 76: 387-417. DOI: 10.1146/annurev.physiol.68.040204.100431.
    [8] VOETS T, PRENEN J, VRIENS J, et al. Molecular determinants of permeation through the cation channel TRPV4[J]. J Biol Chem, 2002, 277(37): 33704-33710. DOI: 10.1074/jbc.M204828200.
    [9] WATANABE H, VRIENS J, JANSSENS A, et al. Modulation of TRPV4 gating by intra- and extracellular Ca2+[J]. Cell Calcium, 2003, 33(5-6): 489-495. DOI: 10.1016/s0143-4160(03)00064-2.
    [10] STROTMANN R, HARTENECK C, NUNNENMACHER K, et al. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity[J]. Nat Cell Biol, 2000, 2(10): 695-702. DOI: 10.1038/35036318.
    [11] MONTELL C, BIRNBAUMER L, FLOCKERZI V, et al. A unified nomenclature for the superfamily of TRP cation channels[J]. Mol Cell, 2002, 9(2): 229-231. DOI: 10.1016/s1097-2765(02)00448-3.
    [12] DELANY NS, HURLE M, FACER P, et al. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2[J]. Physiol Genomics, 2001, 4(3): 165-174. DOI: 10.1152/physiolgenomics.2001.4.3.165.
    [13] EVERAERTS W, NILIUS B, OWSIANIK G. The vanilloid transient receptor potential channel TRPV4: From structure to disease[J]. Prog Biophys Mol Biol, 2010, 103(1): 2-17. DOI: 10.1016/j.pbiomolbio.2009.10.002.
    [14] SURESH K, SERVINSKY L, REYES J, et al. Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4[J]. Am J Physiol Lung Cell Mol Physiol, 2015, 309(12): L1467-L1477. DOI: 10.1152/ajplung.00275.2015.
    [15] NILIUS B, VRIENS J, PRENEN J, et al. TRPV4 calcium entry channel: A paradigm for gating diversity[J]. Am J Physiol Cell Physiol, 2004, 286(2): C195-C205. DOI: 10.1152/ajpcell.00365.2003.
    [16] HOPE JM, GREENLEE JD, KING MR. Mechanosensitive ion channels: TRPV4 and P2X7 in disseminating cancer cells[J]. Cancer J, 2018, 24(2): 84-92. DOI: 10.1097/PPO.0000000000000312.
    [17] ROSENBAUM T, BENÍTEZ-ANGELES M, SÁNCHEZ-HERNÁNDEZ R, et al. TRPV4: A physio and pathophysiologically significant ion channel[J]. Int J Mol Sci, 2020, 21(11): 3837. DOI: 10.3390/ijms21113837.
    [18] VRIENS J, OWSIANIK G, FISSLTHALER B, et al. Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium[J]. Circ Res, 2005, 97(9): 908-915. DOI: 10.1161/01.RES.0000187474.47805.30.
    [19] ZHAN L, YANG Y, MA TT, et al. Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy[J]. Mol Cell Biochem, 2015, 402(1-2): 9-22. DOI: 10.1007/s11010-014-2298-6.
    [20] SONG Y, ZHAN L, YU M, et al. TRPV4 channel inhibits TGF-β1-induced proliferation of hepatic stellate cells[J]. PLoS One, 2014, 9(7): e101179. DOI: 10.1371/journal.pone.0101179.
    [21] SHI M, DU F, LIU Y, et al. Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment[J]. Acta Neuropathol, 2013, 126(5): 725-739. DOI: 10.1007/s00401-013-1166-x.
    [22] JI C, MCCULLOCH CA. TRPV4 integrates matrix mechanosensing with Ca(2+) signaling to regulate extracellular matrix remodeling[J]. FEBS J, 2021, 288(20): 5867-5887. DOI: 10.1111/febs.15665.
    [23] MAIERS JL, KOSTALLARI E, MUSHREF M, et al. The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice[J]. Hepatology, 2017, 65(3): 983-998. DOI: 10.1002/hep.28921.
    [24] HIGASHI T, FRIEDMAN SL, HOSHIDA Y. Hepatic stellate cells as key target in liver fibrosis[J]. Adv Drug Deliv Rev, 2017, 121: 27-42. DOI: 10.1016/j.addr.2017.05.007.
    [25] ROCKEY DC, FRIEDMAN SL. Fibrosis regression after eradication of hepatitis C virus: From bench to bedside[J]. Gastroenterology, 2021, 160(5): 1502-1520. e1. DOI: 10.1053/j.gastro.2020.09.065.
    [26] FU J, DU H, ZHANG X, et al. Pharmacological inhibition of transient receptor potential vanilloid 4 (TRPV4) channel alleviates carbon tetrachloride-induced liver fibrosis in mice[J]. J Nippon Med Sch, 2019, 86(5): 258-262. DOI: 10.1272/jnms.JNMS.2019_86-407.
    [27] YAN H, HAO S, SUN X, et al. Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage[J]. Biochem Biophys Res Commun, 2015, 456(4): 835-840. DOI: 10.1016/j.bbrc.2014.12.073.
    [28] PREMKUMAR KV, CHAUBE SK. RyR channel-mediated increase of cytosolic free calcium level signals cyclin B1 degradation during abortive spontaneous egg activation in rat[J]. In Vitro Cell Dev Biol Anim, 2014, 50(7): 640-647. DOI: 10.1007/s11626-014-9749-y.
    [29] PETRICK JL, FLORIO AA, ZNAOR A, et al. International trends in hepatocellular carcinoma incidence, 1978-2012[J]. Int J Cancer, 2020, 147(2): 317-330. DOI: 10.1002/ijc.32723.
    [30] LYU XB, LUO HS. Relationship between TRP ion channel family and digestive system neoplasms[J]. Chin J Gastroenterol Hepatol, 2021, 30(2): 194-198. DOI: 10.3969/j.issn.1006-5709.2021.02.016.

    吕小斌, 罗和生. TRP离子通道家族和消化系统肿瘤相关性研究[J]. 胃肠病学和肝病学杂志, 2021, 30(2): 194-198. DOI: 10.3969/j.issn.1006-5709.2021.02.016.
    [31] VRIENS J, JANSSENS A, PRENEN J, et al. TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells[J]. Cell Calcium, 2004, 36(1): 19-28. DOI: 10.1016/j.ceca.2003.11.006.
    [32] BUKONG TN, MAURICE SB, CHAHAL B, et al. Versican: A novel modulator of hepatic fibrosis[J]. Lab Invest, 2016, 96(3): 361-374. DOI: 10.1038/labinvest.2015.152.
    [33] SHARMA S, GOSWAMI R, RAHAMAN SO. The TRPV4-TAZ mechanotransduction signaling axis in matrix stiffness- and TGFβ1-induced epithelial-mesenchymal transition[J]. Cell Mol Bioeng, 2019, 12(2): 139-152. DOI: 10.1007/s12195-018-00565-w.
    [34] HUO TY. Research on TRPV4 expression in the liver tumors and its relationship with the developmeat of liver cancer[D]. Taiyuan: Shanxi Medical University, 2019.

    霍天宇. TRPV4在肝脏肿瘤中的表达及其与肝癌发展关系的研究[D]. 太原: 山西医科大学, 2019.
    [35] ZHANG T. Expression of TRPV4 in primary hepatocellular carcinoma and its clinical sigaificance[D]. Changsha: Central South University, 2011.

    张涛. TRPV4在原发性肝细胞癌组织中的表达及临床意义[D]. 长沙: 中南大学, 2011.
    [36] ADAPALA RK, THOPPIL RJ, GHOSH K, et al. Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy[J]. Oncogene, 2016, 35(3): 314-322. DOI: 10.1038/onc.2015.83.
    [37] THOPPIL RJ, ADAPALA RK, CAPPELLI HC, et al. TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation[J]. Sci Rep, 2015, 5: 14257. DOI: 10.1038/srep14257.
    [38] CAPPELLI HC, KANUGULA AK, ADAPALA RK, et al. Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis[J]. Cancer Lett, 2019, 442: 15-20. DOI: 10.1016/j.canlet.2018.07.042.
    [39] KANUGULA AK, ADAPALA RK, MIDHA P, et al. Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4[J]. FASEB J, 2019, 33(1): 195-203. DOI: 10.1096/fj.201800509R.
    [40] GUARINO BD, ADAPALA RK, KANUGULA AK, et al. Extracellular vesicles from pathological microenvironment induce endothelial cell transformation and abnormal angiogenesis via modulation of TRPV4 channels[J]. Front Cell Dev Biol, 2019, 7: 344. DOI: 10.3389/fcell.2019.00344.
    [41] YU S, HUANG S, DING Y, et al. Transient receptor potential ion-channel subfamily V member 4: A potential target for cancer treatment[J]. Cell Death Dis, 2019, 10(7): 497. DOI: 10.1038/s41419-019-1708-9.
    [42] KANUGULA AK, ADAPALA RK, JAMAIYAR A, et al. Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity[J]. Angiogenesis, 2021, 24(3): 647-656. DOI: 10.1007/s10456-021-09775-9.
    [43] LEE-LAW PY, OLAIZOLA P, CABALLERO-CAMINO FJ, et al. Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models[J]. J Hepatol, 2021, 74(2): 394-406. DOI: 10.1016/j.jhep.2020.09.010.
    [44] GRADILONE SA, MASYUK AI, SPLINTER PL, et al. Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion[J]. Proc Natl Acad Sci U S A, 2007, 104(48): 19138-19143. DOI: 10.1073/pnas.0705964104.
    [45] MASYUK TV, MASYUK AI, LARUSSO NF. Therapeutic targets in polycystic liver disease[J]. Curr Drug Targets, 2017, 18(8): 950-957. DOI: 10.2174/1389450116666150427161743.
    [46] SETH RK, DAS S, DATTAROY D, et al. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity[J]. Free Radic Biol Med, 2017, 102: 260-273. DOI: 10.1016/j.freeradbiomed.2016.11.047.
    [47] ECHTERMEYER F, EBERHARDT M, RISSER L, et al. Acetaminophen-induced liver injury is mediated by the ion channel TRPV4[J]. FASEB J, 2019, 33(9): 10257-10268. DOI: 10.1096/fj.201802233R.
    [48] JAFFAL SM, ABBAS MA. TRP channels in COVID-19 disease: Potential targets for prevention and treatment[J]. Chem Biol Interact, 2021, 345: 109567. DOI: 10.1016/j.cbi.2021.109567.
  • 加载中
计量
  • 文章访问数:  440
  • HTML全文浏览量:  152
  • PDF下载量:  30
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-05-30
  • 录用日期:  2021-07-12
  • 出版日期:  2022-01-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回