非酒精性脂肪性肝病体外模型的研究进展

卢晓臣; 韩红梅

doi:10.3969/j.issn.1001-5256.2022.01.035

非酒精性脂肪性肝病体外模型的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.01.035

卢晓臣,
韩红梅^,

延边大学附属医院消化内科，吉林延吉 133000

基金项目:

国家自然科学基金 (81860110)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：卢晓臣负责分析资料，撰写论文，修改论文；韩红梅负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
韩红梅，hanhm79@126.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-05-19
- 录用日期: 2021-06-03
- 出版日期: 2022-01-20

Research advances in in vitro models for nonalcoholic fatty liver disease

Xiaochen LU,
Hongmei HAN^,

Department of Gastroenterology, The Affiliated Hospital of Yanbian University, Yanji, Jilin 133000, China

Research funding:

National Natural Science Foundation of China (81860110)

摘要

摘要: 非酒精性脂肪性肝病发病率逐年上升，其治疗手段有限，对其发病机制的研究是当前热点。为了更好地阐明其发病机制，迫切需要开发先进、安全、有效的体外模型或体内模型，以了解并制订针对该疾病的治疗策略。本文回顾了目前常用于非酒精性脂肪性肝病临床前研究的体外模型，并讨论了其各自的优缺点，为研究非酒精性脂肪性肝病发病机制及治疗提供理论依据。
- 非酒精性脂肪性肝病 /
- 模型, 理论 /
- 病理过程 /
- 治疗学
Abstract: The incidence rate of nonalcoholic fatty liver disease (NAFLD) is increasing year by year, with limited treatment methods, and its pathogenesis is a research hotspot at present. In order to better clarify its pathogenesis, it is urgent to develop advanced, safe, and effective in vitro or in vivo models to understand and develop treatment strategies for this disease. This article reviews the in vitro models commonly used in the preclinical study of NAFLD and discusses their advantages and disadvantages, so as to provide a theoretical basis for the pathogenesis and treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Models, Theoretical /
- Pathologic Processes /
- Therapeutics

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