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IgG4相关性疾病与自身免疫性肝炎的关系

张丽丽 耿爱文 亓传旺 咸建春

引用本文:
Citation:

IgG4相关性疾病与自身免疫性肝炎的关系

DOI: 10.3969/j.issn.1001-5256.2021.12.050
基金项目: 

江苏省泰州市科技支撑计划(社会发展)项目 (TS201813)

详细信息
    通信作者:

    亓传旺,qichuanwang1104@163.com

  • 中图分类号: R575

Association between immunoglobulin G4-related diseases and autoimmune hepatitis

Research funding: 

Jiangsu Taizhou Science and Technology Support Plan (Social Development) Project (TS201813)

  • 摘要: 随着疾病认识及诊疗水平的不断提高,免疫球蛋白G4相关性疾病(IgG4-RD)和自身免疫性肝病的发病率呈上升趋势,IgG4相关性硬化性胆管炎为二者疾病谱的交叉部分,但IgG4相关性自身免疫性肝炎(IgG4-AIH)和二者之间的关系尚不明确。本文回顾了IgG4-RD在肝脏的表现,归纳总结IgG4-AIH的临床特点,并对IgG4-AIH是AIH的一种亚型还是IgG4-RD累及肝脏这一问题进行分析,认为IgG4-AIH与经典AIH的临床表现及组织病理学特点相似而又有不同,IgG4-AIH或许可分为两种类型,即AIH的一种亚型和IgG4-RD的肝脏表现。IgG4-AIH的发病机制、临床特征、临床诊治等方面的研究值得继续关注。

     

  • [1] UMEMURA T, ZEN Y, HAMANO H, et al. Immunoglobin G4-hepatopathy: Association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis[J]. Hepatology, 2007, 46(2): 463-471. DOI: 10.1002/hep.21700.
    [2] MINAGA K, WATANABE T, CHUNG H, et al. Autoimmune hepatitis and IgG4-related disease[J]. World J Gastroenterol, 2019, 25(19): 2308-2314. DOI: 10.3748/wjg.v25.i19.2308.
    [3] HARADA K, NAKANUMA Y. Pathological differences between IgG4-related sclerosing cholangitis with and without autoimmune pancreatitis[J]. Mod Pathol, 2013, 26(1): 403. DOI: 10.1038/modpathol.2013.17.
    [4] ZENG ZL, LI YL. Research progress in liver injury caused by IgG4- related diseases[J]. Chin J Pract Intern Med, 2021, 41(4): 291-295, 300. DOI: 10.19538/j.nk2021040106.

    曾子露, 李异玲. IgG4相关性疾病肝损伤的研究进展[J]. 中国实用内科杂志, 2021, 41(4): 291-295, 300. DOI: 10.19538/j.nk2021040106.
    [5] ZEN Y, FUJⅡ T, SATO Y, et al. Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease[J]. Mod Pathol, 2007, 20(8): 884-894. DOI: 10.1038/modpathol.3800836.
    [6] WANG M, ZHANG S, YANG Q. IgG4-related hepatic inflammatory pseudotumor misdiagnosed as cholangiocellular carcinoma of the liver[J]. J Gastrointest Surg, 2021, 25(4): 1065-1066. DOI: 10.1007/s11605-019-04405-8.
    [7] YUEH HZ, TUNG KK, TUNG CF. IgG4-related pseudotumors mimicking metastases in liver and lungs[J]. Case Rep Gastroenterol, 2021, 15(1): 163-170. DOI: 10.1159/000512410.
    [8] ADACHI Y, IWATA N, ADACHI Y, et al. Coexistence of IgG4-related autoimmune hepatitis and inflammatory pseudotumors of the liver: a case report[J]. Nihon Shokakibyo Gakkai Zasshi, 2020, 117(6): 532-541. DOI: 10.11405/nisshoshi.117.532.
    [9] JANDEE S, BOONSRI P. Atypical manifestations of igg4-related disease as multiple liver abscesses with subcapsular tracts and migratory pulmonary nodules mimicking parasitic infection[J]. Case Rep Gastroenterol, 2020, 14(3): 458-466. DOI: 10.1159/000509501.
    [10] UMEMURA T, ZEN Y, HAMANO H, et al. IgG4 associated autoimmune hepatitis: A differential diagnosis for classical autoimmune hepatitis[J]. Gut, 2007, 56(10): 1471-1472. DOI: 10.1136/gut.2007.122283.
    [11] UMEMURA T, ZEN Y, HAMANO H, et al. Clinical significance of immunoglobulin G4-associated autoimmune hepatitis[J]. J Gastroenterol, 2011, 46(Suppl 1): 48-55. DOI: 10.1007/s00535-010-0323-4.
    [12] CHUNG H, WATANABE T, KUDO M, et al. Identification and characterization of IgG4-associated autoimmune hepatitis[J]. Liver Int, 2010, 30(2): 222-231. DOI: 10.1111/j.1478-3231.2009.02092.x.
    [13] CANIVET CM, ANTY R, PATOURAUX S, et al. Immunoglobulin G4-associated autoimmune hepatitis may be found in Western countries[J]. Dig Liver Dis, 2016, 48(3): 302-308. DOI: 10.1016/j.dld.2015.10.005.
    [14] AYDEMIR Y, AKCOREN Z, DEMIR H, et al. Clinical and histopathological features of immunoglobulin G4-associated autoimmune hepatitis in children[J]. J Gastroenterol Hepatol, 2019, 34(4): 742-746. DOI: 10.1111/jgh.14525.
    [15] ARASE Y, MATSUMOTO K, ANZAI K, et al. Clinicopathological features of autoimmune hepatitis with IgG4-positive plasma cell infiltration[J]. Dig Dis, 2021, 39(3): 225-233. DOI: 10.1159/000510562.
    [16] AMARAPURKAR AD, AMARAPURKAR DN. Immunoglobulin IgG4 and autoimmune hepatitis[J]. Trop Gastroenterol, 2015, 36(2): 112-117. DOI: 10.7869/tg.263.
    [17] ZHANG W, ZENG XF. Focusing on rare rheumatic diseases and standardizing the management of IgG4 related diseases[J]. Chin J Intern Med, 2021, 60(3): 185-186. DOI: 10.3760/cma.j.cn112138-20200803-00727.

    张文, 曾小峰. 聚焦风湿罕见病, 规范IgG4相关性疾病的诊治[J]. 中华内科杂志, 2021, 60(3): 185-186. DOI: 10.3760/cma.j.cn112138-20200803-00727.
    [18] DING DS, TU DN, WANG L, et al. Clinical and pathological features of IgG4-related autoimmune hepatitis in children[J]. J Prac Hepatol, 2020, 23(1): 34-37. DOI: 10.3969/j.issn.1672-5069.2020.01.011.

    丁冬胜, 涂丹娜, 王丽, 等. 儿童IgG4相关自身免疫性肝炎临床与病理特征分析[J]. 实用肝脏病杂志, 2020, 23(1): 34-37. DOI: 10.3969/j.issn.1672-5069.2020.01.011.
    [19] MOHAPATRA S, CHARILAOU P, SHARMA A, et al. Significance of peripheral eosinophilia for diagnosis of IgG4-related disease in subjects with elevated serum IgG4 levels[J]. Pancreatology, 2020, 20(1): 74-78. DOI: 10.1016/j.pan.2019.11.016.
    [20] KASTIN D, SIEGEL M, ANDERSON R, et al. IgG 4 autoimmune hepatitis presenting as idiopathic hypereosinophilia syndrome[J]. Hepatology, 2021, 73(4): 1615-1617. DOI: 10.1002/hep.31492.
    [21] CHANG A, CHAROENLAP C, AKARAPATIMA K, et al. Immunoglobulin G4-associated autoimmune hepatitis with peripheral blood eosinophilia: A case report[J]. BMC Gastroenterol, 2020, 20(1): 420. DOI: 10.1186/s12876-020-01559-7.
    [22] ARASE Y, MATSUMOTO K, ANZAI K, et al. Clinicopathological features of autoimmune hepatitis with IgG4-positive plasma cell infiltration[J]. Dig Dis, 2021, 39(3): 225-233. DOI: 10.1159/000510562.
    [23] GONG L, SHI JP. Treatment and prognosis of immunoglobulin G4-related hepatobiliary disease[J]. Chin J Hepatol, 2018, 26(6): 411-414. DOI: 10.3760/cma.j.issn.1007-3418.2018.06.004.

    龚玲, 施军平. 免疫球蛋白G4相关肝胆疾病的治疗与转归[J]. 中华肝脏病杂志, 2018, 26(6): 411-414. DOI: 10.3760/cma.j.issn.1007-3418.2018.06.004.
    [24] WALLACE ZS, MATTOO H, MAHAJAN VS, et al. Predictors of disease relapse in IgG4-related disease following rituximab[J]. Rheumatology (Oxford), 2016, 55(6): 1000-1008. DOI: 10.1093/rheumatology/kev438.
    [25] WANG R, TANG R, LI B, et al. Gut microbiome, liver immunology, and liver diseases[J]. Cell Mol Immunol, 2021, 18(1): 4-17. DOI: 10.1038/s41423-020-00592-6.
    [26] ZHANG W, DONG LL, ZHU J, et al. Chinese expert consensus on the diagnosis and treatment of IgG4 related diseases[J]. Chin J Intern Med, 2021, 60(3): 192-206. DOI: 10.3760/cma.j.cn112138-20200803-00726.

    张文, 董凌莉, 朱剑, 等. IgG4相关性疾病诊治中国专家共识[J]. 中华内科杂志, 2021, 60(3): 192-206. DOI: 10.3760/cma.j.cn112138-20200803-00726.
    [27] JOSHI D, WEBSTER GJ. Biliary and hepatic involvement in IgG4-related disease[J]. Aliment Pharmacol Ther, 2014, 40(11-12): 1251-1261. DOI: 10.1111/apt.12988.
    [28] KANG MK, PARK JG, CHOI JH. Anti-nuclear antibody-negative immunoglobulin G4-associated autoimmune hepatitis mimicking lymphoproliferative disorders[J]. Yeungnam Univ J Med, 2020, 37(2): 136-140. DOI: 10.12701/yujm.2020.00066.
    [29] MA SF, LIN J, ZANG LJ, et al. Clinicopathologic features of IgG4-related disease[J]. Chin J Clin Exp Pathol, 2021, 37(4): 415-419. DOI: 10.13315/j.cnki.cjcep.2021.04.008.

    马少飞, 林军, 臧丽娟, 等. IgG4相关性疾病的临床病理特征[J]. 临床与实验病理学杂志, 2021, 37(4): 415-419. DOI: 10.1335/j.cnki.cjcep.2021.04.008.
    [30] NAKANUMA Y, ISHIZU Y, ZEN Y, et al. Histopathology of IgG4-related autoimmune hepatitis and IgG4-related hepatopathy in IgG4-related disease[J]. Semin Liver Dis, 2016, 36(3): 229-241. DOI: 10.1055/s-0036-1584320.
    [31] ZHANG DH, ZHAO J. Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases[J]. J Clin Hepatol, 2019, 35(6): 1401-1405. DOI: 10.3969 /j.issn.1001-5256.2019.06.050.

    张德华, 赵婕. IgG4相关性肝胆胰疾病的发病机制[J]. 临床肝胆病杂志, 2019, 35(6): 1401-1405. DOI: 10.3969 /j.issn.1001-5256.2019.06.050.
    [32] SHIOKAWA M, KODAMA Y, SEKIGUCHI K, et al. Laminin 511 is a target antigen in autoimmune pancreatitis[J]. Sci Transl Med, 2018, 10(453): eaaq0997. DOI: 10.1126/scitranslmed.aaq0997.
    [33] HUBERS LM, VOS H, SCHUURMAN AR, et al. Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease[J]. Gut, 2018, 67(4): 728-735. DOI: 10.1136/gutjnl-2017-314548.
    [34] PERUGINO CA, ALSALEM SB, MATTOO H, et al. Identification of galectin-3 as an autoantigen in patients with IgG4-related disease[J]. J Allergy Clin Immunol, 2019, 143(2): 736-745. e6. DOI: 10.1016/j.jaci.2018.05.011.
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  • 收稿日期:  2021-08-24
  • 录用日期:  2021-09-13
  • 出版日期:  2021-12-20
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