慢加急性肝衰竭的免疫治疗

覃小宾; 张荣臻; 吴聪; 曾胜澜; 乐滢玉; 毛德文

doi:10.3969/j.issn.1001-5256.2021.11.046

慢加急性肝衰竭的免疫治疗

DOI: 10.3969/j.issn.1001-5256.2021.11.046

1.
广西中医药大学研究生学院，南宁 530001
2.
广西中医药大学第一附属医院肝病科，南宁 530023

基金项目:

国家自然科学基金 (81960841);

国家自然科学基金面上项目 (82060848);

广西自然科学基金课题 (2018GXNSFAA281096);

广西自然科学基金课题 (2020JJA140273)

详细信息

通信作者:
毛德文，mdwboshi2005@163.com

中图分类号: R575.3
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- 文章访问数: 447
- HTML全文浏览量: 144
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- 被引次数: 0
出版历程
- 收稿日期: 2021-03-28
- 录用日期: 2021-04-21
- 出版日期: 2021-11-20

Immunotherapy for acute-on-chronic liver failure

1.
Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, China
2.
Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

National Natural Science Foundation Project （81960841）

General Project of National Natural Science Foundation Project （82060848）

Guangxi Natural Science Fund Project （2018GXNSFAA281096）

Guangxi Natural Science Fund Project （2020JJA140273）

摘要

摘要: 慢加急性肝衰竭(ACLF)是一种严重威胁生命的疾病，具有多器官衰竭、脓毒症和死亡的高风险。ACLF在体内激活先天免疫反应和获得性免疫反应，从而引起持续的全身炎症反应综合征和多器官功能障碍的发展，导致该病的高病死率。失调的免疫反应在疾病进展中起关键作用，免疫疗法可能有助于针对免疫介导的器官损伤，抑制肝衰竭的进展，就目前ACLF中具有潜在免疫调节作用的药物与手段的作用及其机制进行了综述，以期为ACLF的免疫治疗提供参考。
- 慢加急性肝功能衰竭 /
- 免疫调节 /
- 肝再生 /
- 药用制剂 /
- 肝, 人工
Abstract: Acute-on-chronic liver failure (ACLF) is a life-threatening disease with a high risk of multiple organ failure, sepsis, and death. ACLF activates innate and acquired immune responses in human body and thus leads to the progression of persistent systemic inflammatory response syndrome and multiple organ dysfunction, leading to the high mortality rate of this disease. Dysregulated immune response plays a key role in disease progression, and immunotherapy may help to target immune-mediated organ damage and inhibit the progression of liver failure. This article reviews the role and mechanism of drugs and means with a potential immune regulatory effect in ACLF, in order to provide a reference for immunotherapy for ACLF.
- Acute-On-Chronic Liver Failure /
- Immunomodulation /
- Liver Regeneration /
- Pharmaceutical Preparations /
- Liver, Artificial

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参考文献(49)

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