脾酪氨酸激酶在肝脏疾病中的作用机制

乐滢玉; 张荣臻; 吴聪; 肖伟松; 覃小宾; 曾胜澜; 毛德文

doi:10.3969/j.issn.1001-5256.2021.08.049

脾酪氨酸激酶在肝脏疾病中的作用机制

DOI: 10.3969/j.issn.1001-5256.2021.08.049

1.
广西中医药大学研究生学院，南宁 530222
2.
广西中医药大学第一附属医院肝病一区，南宁 530023

基金项目:

国家自然科学基金面上项目 (81774236);

国家自然科学基金 (81960841);

广西自然科学基金 (2018GXNSFAA281096);

广西科技计划项目-广西科技基地和人才专项 (GK AD17129001)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：毛德文、乐滢玉负责研究选题；张荣臻、吴聪、肖伟松负责设计论文框架，起草论文；毛德文、乐滢玉负责拟定写作思路，指导撰写文章并最后定稿；覃小宾、曾胜澜负责修订论文。

详细信息

通信作者:
毛德文，mdwboshi2005@163.com

中图分类号: R575
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- 文章访问数: 550
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- 被引次数: 0
出版历程
- 收稿日期: 2020-12-29
- 录用日期: 2021-01-18
- 出版日期: 2021-08-20

Mechanism of action of spleen tyrosine kinase in liver diseases

1.
Graduate School of Guangxi University of Chinese Medicine, Nanning 530222, China
2.
Division I of Liver Disease, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

General Project of National Natural Science Foundation of China (81774236);

National Natural Science Foundation of China (81960841);

Natural Science Foundation of Guangxi Province (2018GXNSFAA281096);

Guangxi Science and Technology Program Project - Guangxi Science and Technology Base and Talent Special Project (GK AD17129001)

摘要

摘要: 脾酪氨酸激酶(Syk)是一种在大多数造血细胞和非造血细胞中表达的非受体酪氨酸激酶，在免疫和非免疫生物学反应中都起着至关重要的作用。Syk通过免疫受体酪氨酸激活基序(ITAM)依赖性的信号通路和ITAM半依赖性的信号通路等介导多种细胞反应。已有研究表明，Syk在肝实质细胞和非实质细胞中表达，并与肝纤维化、病毒性肝炎、酒精性肝病、非酒精性脂肪性肝炎和肝细胞癌等肝脏疾病的发病机制及防治密切相关。对Syk在慢性肝脏疾病中的作用特点及调控机制进行归纳总结，以期为肝脏疾病的治疗提供思路和依据。
- Syk激酶 /
- 肝疾病 /
- 病理过程
Abstract: Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase expressed in most hematopoietic and non-hematopoietic cells and plays an important role in both immune and non-immune biological responses. Syk mediates a variety of cellular responses through immunoreceptor tyrosine-based activation motifs (ITAM)-dependent and ITAM-semi-dependent signaling pathways. Studies have shown that Syk is expressed in liver parenchymal cells and nonparenchymal cells and is closely associated with the pathogenesis, prevention, and treatment of various liver diseases such as liver fibrosis, viral hepatitis, alcoholic liver disease, nonalcoholic steatohepatitis, and hepatocellular carcinoma. This article summarizes the feature and regulatory mechanism of Syk in chronic liver diseases, in order to provide ideas and basis for the treatment of liver diseases.
- Syk Kinase /
- Liver Diseases /
- Pathologic Processes

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参考文献(50)

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