肝祖细胞与肝再生的关系

王俊俊; 陆伦根; 蔡晓波

doi:10.3969/j.issn.1001-5256.2021.08.048

肝祖细胞与肝再生的关系

DOI: 10.3969/j.issn.1001-5256.2021.08.048

上海交通大学附属第一人民医院消化科，上海 200080

基金项目:

国家新药开发重大科技专项基金资助项目 (2018ZX09201016)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：王俊俊负责文章结构设计，撰写文章；陆伦根负责收集、筛选文献，修改文章；蔡晓波负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
蔡晓波，caixiaobo1979@hotmail.com

中图分类号: R575
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- 被引次数: 0
出版历程
- 收稿日期: 2021-01-07
- 录用日期: 2021-01-28
- 出版日期: 2021-08-20

Association between liver progenitor cells and liver regeneration

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

Research funding:

Major Scientific and Technological Funding Project of National New Drug Development (2018ZX09201016)

摘要

摘要: 肝脏具有极强的再生能力，在急性肝损伤或肝大部分切除后残存的肝细胞迅速进入复制状态。而在慢性肝损伤或重症肝病时，肝祖细胞(LPC)介导的再生在肝再生中可能起到主要作用。目前已经通过谱系追踪和单细胞测序方法在动物和人方面均证实了双能LPC的存在。且多项研究显示LPC增殖程度与肝损伤严重程度有关。简述了LPC的起源与激活，以及LPC在不同类型肝损伤中介导肝再生的作用和调节机制。指出未来需要对LPC进行深入研究，以期为LPC移植重建肝实质和晚期肝病治疗提供依据。
- 干细胞 /
- 肝再生 /
- 胆管反应
Abstract: The liver has a strong ability of regeneration and the remaining liver cells can quickly enter the replication state after acute liver injury or partial hepatectomy. In case of chronic liver injury or severe liver disease, liver progenitor cell (LPC)-mediated regeneration may play a major role in liver regeneration. At present, the presence of dual-energy LPCs in animals and humans has been confirmed by lineage tracing and single-cell sequencing, and many studies have shown that the degree of LPC proliferation is associated with the severity of liver injury. This article briefly describes the origin and activation of LPCs and the role and regulatory mechanism of LPCs in mediating liver regeneration in different types of liver injury, and it is pointed out that in-depth research is needed for LPCs in the future to provide a basis for the reconstruction of liver parenchyma and the treatment of advanced liver disease by LPC transplantation.
- Stem Cells /
- Liver Regeneration /
- Ductular Reaction

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参考文献(40)

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