细胞自噬及其在肝纤维化中的作用

代倩兰; 刘绍能

doi:10.3969/j.issn.1001-5256.2021.06.046

细胞自噬及其在肝纤维化中的作用

DOI: 10.3969/j.issn.1001-5256.2021.06.046

代倩兰,
刘绍能^,

中国中医科学院广安门医院消化内科，北京 100053

基金项目:

国家自然科学基金 (81973832)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：代倩兰负责查找文献，资料分析，撰写论文；刘绍能负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
代倩兰(1991—)，女，主要从事肝纤维化的基础和临床研究

通信作者:
刘绍能，liushaoneng@126.com

中图分类号: R575.2
计量
- 文章访问数: 689
- HTML全文浏览量: 317
- PDF下载量: 76
- 被引次数: 0
出版历程
- 收稿日期: 2020-11-23
- 录用日期: 2020-12-16
- 出版日期: 2021-06-20

Role of autophagy in liver fibrosis

Qianlan DAI,
Shaoneng LIU^,

Department of Gastroenterology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

摘要

摘要: 自噬是指真核细胞内细胞器、蛋白质等在溶酶体中被降解及其降解产物被重新利用的过程，其对细胞的增殖、分化及稳态起着重要作用。近年来，自噬在肝纤维化中的作用受到越来越多的关注，干预自噬也许成为治疗肝纤维化的新方法。总结了自噬的过程、功能及在肝纤维化中作用，这些研究揭示了自噬对肝纤维化作用机制的复杂性，也启示未来需要找到干预自噬更加可靠、确定的机制和靶点，进而为治疗肝纤维化提供新途径。
- 自噬 /
- 肝硬化 /
- 肝星状细胞
Abstract: Autophagy refers to the process in which organelles and proteins in eukaryocytes are degraded in lysosomes and their degradation products are reused, and it plays an important role in cell proliferation, differentiation, and homeostasis. In recent years, the role of autophagy in liver fibrosis has attracted more and more attention, and intervention of autophagy may become a new method for the treatment of liver fibrosis. This article summarizes the process and function of autophagy and its role in liver fibrosis. These data reveal the complex mechanism of action of autophagy in liver fibrosis and point out the need to find more reliable and definite mechanisms and targets for autophagy intervention in the future, so as to provide new ways for the treatment of liver fibrosis.
- Autophagy /
- Liver Cirrhosis /
- Hepatic Stellate Cell

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