慢性乙型肝炎合并特发性门静脉高压症1例报告

朱芳; 张振江; 袁玲; 裴兵

doi:10.3969/j.issn.1001-5256.2021.06.038

慢性乙型肝炎合并特发性门静脉高压症1例报告

DOI: 10.3969/j.issn.1001-5256.2021.06.038

朱芳^a,
张振江^a, ,,
袁玲^a,
裴兵^b

a.
南京医科大学附属宿迁第一人民医院感染病科, 江苏宿迁 223800
b.
南京医科大学附属宿迁第一人民医院检验科, 江苏宿迁 223800

基金项目:

宿迁市临床医学检验实验室 (M201902)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：朱芳负责课题设计，拟定写作思路，撰写论文；袁玲负责收集数据；张振江、裴兵负责指导撰写文章并定稿。

详细信息

作者简介:
朱芳(1987—)，女，主治医师，主要从事感染病科临床及基础研究工作

通信作者:
张振江，zzj80526305@126.com

中图分类号: R575.21
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- 文章访问数: 328
- HTML全文浏览量: 90
- PDF下载量: 44
- 被引次数: 0
出版历程
- 收稿日期: 2020-11-04
- 录用日期: 2020-12-29
- 出版日期: 2021-06-20

A case of idiopathic portal hypertension in chronic hepatitis B

a.
Department of Infectious Diseases, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu 223800, China
b.
Department of Clinical Laboratory, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu 223800, China

摘要

- 高血压，门静脉 /
- 乙型肝炎，慢性 /
- 肝硬化
- Hypertension, Portal /
- Hepatitis B Chromic /
- Liver Cirrhosis

HTML全文

图 1 上腹部增强CT检查

注：a，门静脉增宽(16.04 mm，箭头所示)、脾肿大；b，食管静脉曲张(箭头所示)。

下载: 全尺寸图片幻灯片

图 2 肝组织病理检查

注：a，汇管区炎症(免疫组化，×40)；b，点状坏死(免疫组化，×40)；c，HBsAg(免疫组化，×100)；d，CK19胆管上皮(免疫组化，×100)；e、f，Masson及天狼猩红染色示汇管区纤维组织增生(×40)。

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图 3 门静脉超声检查

注：a，门静脉增宽，通畅；b，门静脉流速降低；c，肝静脉通畅。

下载: 全尺寸图片幻灯片

参考文献(14)

[1]	GUIDO M, SARCOGNATO S, SACCHI D, et al. Pathology of idiopathic non-cirrhotic portal hypertension[J]. Virchows Arch, 2018, 473(1): 23-31. DOI: 10.1007/s00428-018-2355-8.
[2]	Working Subgroup for Clinical Practice Guideline for Aberrant Portal Hemodynamics. Diagnosis and treatment guidelines for aberrant portal hemodynamics: The Aberrant Portal Hemodynamics Study Group supported by the Ministry of Health, Labor and Welfare of Japan[J]. Hepatol Res, 2017, 47(5): 373-386. DOI: 10.1111/hepr.12862.
[3]	SARIN SK. Non-cirrhotic portal hypertension[M]//Advances in Therapeutic Hepatology: A World View. Chicago: IASL, 1998: 111-124.
[4]	ZHANG Y, TANG SH, MOU D, et al. A case of idiopathic portal hypertension[J]. J Clin Hepatol, 2017, 33(4): 738-739. DOI: 10.3969/j.issn.1001-5256.2017.04.031.
[5]	ZHU Q, XIANG CH. Current status regarding diagnosis and management of idiopathic portal hypertension[J]. Chin J Gen Surg, 2019, 28(1): 117-124. DOI: 10.7659/j.issn.1005-6947.2019.01.016. 朱青, 项灿宏. 特发性门静脉高压症的诊治现状[J]. 中国普通外科杂志, 2019, 28(1): 117-124. DOI: 10.7659/j.issn.1005-6947.2019.01.016.
[6]	HERNÁNDEZ-GEA V, BAIGES A, TURON F, et al. Idiopathic portal hypertension[J]. Hepatology, 2018, 68(6): 2413-2423. DOI: 10.1002/hep.30132.
[7]	GÓMEZ ALONSO M, GOÑI ESARTE S, BOLADO CONCEJO F, et al. Idiopathic non-cirrhotic portal hypertension and portal vein thrombosis in a patient with HIV infection[J]. Gastroenterol Hepatol, 2017, 40(5): 353-354. DOI: 10.1016/j.gastrohep.2016.03.005.
[8]	POLA S, BOLAND BS, LIN GY, et al. Non-cirrhotic portal hypertension due to 6-mercaptopurine use for Crohn's disease[J]. Dig Dis Sci, 2014, 59(7): 1642-1644. DOI: 10.1007/s10620-014-3052-3.
[9]	KOOT BG, ALDERS M, VERHEIJ J, et al. A de novo mutation in KCNN3 associated with autosomal dominant idiopathic non-cirrhotic portal hypertension[J]. J Hepatol, 2016, 64(4): 974-977. DOI: 10.1016/j.jhep.2015.11.027.
[10]	CAI MX, LIN LW, XUE ES, et al. Color Doppler in the diagnosis of idiopathic portal hypertension and its clinical value[J]. J Clin Hepatol, 2009, 25(5): 374-376. http://lcgdbzz.org/article/id/LCGD200905023 蔡敏娴, 林礼务, 薛恩生, 等. 特发性门静脉高压症的彩色多普勒超声诊断与临床价值[J]. 临床肝胆病杂志, 2009, 25(5): 374-376. http://lcgdbzz.org/article/id/LCGD200905023
[11]	SHARMA P, AGARWAL R, DHAWAN S, et al. Transient elastography (fibroscan) in patients with non-cirrhotic portal fibrosis[J]. J Clin Exp Hepatol, 2017, 7(3): 230-234. DOI: 10.1016/j.jceh.2017.03.002.
[12]	LIU X, WANG TL, XIANG CH, et al. Liver pathology in idiopathic portal hypertension[J]. Chin J Hepatol, 2007, 15(5): 374-377. DOI: 10.3760/j.issn:1007-3418.2007.05.015. 刘霞, 王泰龄, 项灿宏, 等. 特发性门静脉高压的肝脏病理学分析[J]. 中华肝脏病杂志, 2007, 15(5): 374-377. DOI: 10.3760/j.issn:1007-3418.2007.05.015.
[13]	European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Vascular diseases of the liver[J]. J Hepatol, 2016, 64(1): 179-202. DOI: 10.1016/j.jhep.2015.07.040.
[14]	XU HF, DING HG. Diagnosis and treatment of pre-hepatic (sinusoidal) non-cirrhotic portal hypertension and related difficulties[J]. J Clin Hepatol, 2019, 35(1): 13-17. DOI: 10.3969/j.issn.1001-5256.2019.01.002. 徐航飞, 丁惠国. 肝(窦)前型非肝硬化门静脉高压症的诊断与治疗及其面临的困境[J]. 临床肝胆病杂志, 2019, 35(1): 13-17. DOI: 10.3969/j.issn.1001-5256.2019.01.002.