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肝细胞癌非手术治疗的发展现状

于志远 杨诗语 李佳启 孙岩

引用本文:
Citation:

肝细胞癌非手术治疗的发展现状

DOI: 10.3969/j.issn.1001-5256.2021.05.048
基金项目: 

黑龙江省自然基金资助项目 (H2016028)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:于志远、杨诗语负责文章选题,资料分析,撰写论文;于志远、李佳启负责整理文献,设计论文框架及修改论文;孙岩负责帮助拟定写作思路,批改文章并最后定稿。
详细信息
    作者简介:

    于志远(1995—),男,主要从事肝胆疾病诊治方面的研究

    通信作者:

    孙岩,sunyandoctor@163.com

  • 中图分类号: R735.7

Current developmental status of non-surgical treatment of hepatocellular carcinoma

  • 摘要: 肝细胞癌是临床上常见且死亡率较高的恶性肿瘤之一。随着影像及介入技术的进步,经肝动脉化疗栓塞术、局部消融治疗等应用日益广泛,在某些早期肝细胞癌的治疗中甚至能达到与手术相同的效果。精准医学和生物医学也得到蓬勃发展,放化疗被更准确、有效的应用于肝细胞癌的治疗中,分子靶向治疗、免疫治疗、基因治疗等成为未来的突破方向。就肝细胞癌非手术治疗的最新进展进行综述。

     

  • [1] XIE DY, REN ZG, ZHOU J, et al. 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: Updates and insights[J]. Hepatobiliary Surg Nutr, 2020, 9(4): 452-463. DOI: 10.21037/hbsn-20-480.
    [2] LLOVET JM, BRUIX J. Novel advancements in the management of hepatocellular carcinoma in 2008[J]. J Hepatol, 2008, 48(Suppl 1): s20-s37. DOI: 10.1016/j.jhep.2008.01.022.
    [3] ZHU ZM, ZHAO ZJ, TANG CX. Research advances in apatinib combined with transcatheter arterial embolization in the treatment of hepatocellular carcinoma[J]. J Clin Hepatol, 2020, 36(10): 2325-2328. DOI: 10.3969/j.issn.1001-5256.2020.10.036.

    朱泽民, 赵志坚, 唐才喜. 阿帕替尼联合经肝动脉化疗栓塞术治疗肝细胞癌的研究进展[J]. 临床肝胆病杂志, 2020, 36(10): 2325-2328. DOI: 10.3969/j.issn.1001-5256.2020.10.036.
    [4] HUANG D, DAI H, TANG K, et al. A versatile UCST-type composite microsphere for image-guided chemoembolization and photothermal therapy against liver cancer[J]. Nanoscale, 2020, 12(38): 20002-20015. DOI: 10.1039/d0nr04592f.
    [5] ZHAO J, LI YS, LIU ZX, et al. Nanosized drug-eluting bead for transcatheter arterial chemoembolization (ND-TACE)[J]. J Mater Chem B, 2020, 8(37): 8684-8694. DOI: 10.1039/d0tb01295e.
    [6] GUO QY, WEN F. Current situation and prospect of interventional treatment of hepatocellular carcinoma[J]. J Clin Hepatol, 2013, 29(10): 721-725. DOI: 10.3969/j.issn.1001-5256.2013.10.001.

    郭启勇, 温锋. 肝细胞癌介入治疗的现状与展望[J]. 临床肝胆病杂志, 2013, 29(10): 721-725. DOI: 10.3969/j.issn.1001-5256.2013.10.001.
    [7] TSAI WL, SUN WC, CHEN WC, et al. Hepatic arterial infusion chemotherapy vs transcatheter arterial embolization for patients with huge unresectable hepatocellular carcinoma[J]. Medicine (Baltimore), 2020, 99(32): e21489. DOI: 10.1097/MD.0000000000021489.
    [8] YOUNG S, CRAIG P, GOLZARIAN J. Current trends in the treatment of hepatocellular carcinoma with transarterial embolization: A cross-sectional survey of techniques[J]. Eur Radiol, 2019, 29(6): 3287-3295. DOI: 10.1007/s00330-018-5782-7.
    [9] YOON SM, RYOO BY, LEE SJ, et al. Efficacy and safety of transarterial chemoembolization plus external beam radiotherapy vs sorafenib in hepatocellular carcinoma with macroscopic vascular invasion: A randomized clinical Trial[J]. JAMA Oncol, 2018, 4(5): 661-669. DOI: 10.1001/jamaoncol.2017.5847.
    [10] VIETTI VIOLI N, DURAN R, GUIU B, et al. Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: A randomised controlled phase 2 trial[J]. Lancet Gastroenterol Hepatol, 2018, 3(5): 317-325. DOI: 10.1016/S2468-1253(18)30029-3.
    [11] Bureau of Medical AdministrationNational Health Commission of the People's Republic of China. Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition)[J]. J Clin Hepatol, 2020, 36(2): 277-292. DOI: 10.3969/j.issn.1001-5256.2020.02.007.

    中华人民共和国国家卫生健康委员会医政医管局. 原发性肝癌诊疗规范(2019年版)[J]. 临床肝胆病杂志, 2020, 36(2): 277-292. DOI: 10.3969/j.issn.1001-5256.2020.02.007.
    [12] YAMAO T, IMAI K, YAMASHITA YI, et al. Surgical treatment strategy for hepatocellular carcinoma in patients with impaired liver function: Hepatic resection or radiofrequency ablation?[J]. HPB (Oxford), 2018, 20(3): 244-250. DOI: 10.1016/j.hpb.2017.08.031.
    [13] SCHER N, JANORAY G, RIET FG, et al. Stereotactic body radiation therapy for hepatocellular carcinoma: Results from a retrospective multicentre study[J]. Cancer Radiother, 2019, 23(2): 104-115. DOI: 10.1016/j.canrad.2018.07.138.
    [14] SEKINO Y, OKUMURA T, FUKUMITSU N, et al. Proton beam therapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus[J]. J Cancer Res Clin Oncol, 2020, 146(3): 711-720. DOI: 10.1007/s00432-019-03096-7.
    [15] SHIBUYA K, OHNO T, TERASHIMA K, et al. Short-course carbon-ion radiotherapy for hepatocellular carcinoma: A multi-institutional retrospective study[J]. Liver Int, 2018, 38(12): 2239-2247. DOI: 10.1111/liv.13969.
    [16] LEE EW, ALANIS L, CHO SK, et al. Yttrium-90 selective internal radiation therapy with glass microspheres for hepatocellular carcinoma: Current and updated literature review[J]. Korean J Radiol, 2016, 17(4): 472-488. DOI: 10.3348/kjr.2016.17.4.472.
    [17] TAYLOR AC, MADDIRELA D, WHITE SB. Role of radioembolization for biliary tract and primary liver cancer[J]. Surg Oncol Clin N Am, 2019, 28(4): 731-743. DOI: 10.1016/j.soc.2019.07.001.
    [18] 王艳红. 肝癌的综合治疗之我见[J/CD]. 中华临床医师杂志(电子版), 2015, 9(19): 3488-3493. DOI:10.3877/cma.j.issn.1674-0785.2015.19.002.

    WANG YH. Comprehensive treatment of liver cancer[J/CD]. Chin J Clinicians(Electronic Edition), 2015, 9(19): 3488-3493. DOI:10.3877/cma.j.issn.1674-0785.2015.19.002.
    [19] HUANG S, LI C, WANG W, et al. A54 peptide-mediated functionalized gold nanocages for targeted delivery of DOX as a combinational photothermal-chemotherapy for liver cancer[J]. Int J Nanomedicine, 2017, 12: 5163-5176. DOI: 10.2147/IJN.S131089.
    [20] BRUIX J, TAKAYAMA T, MAZZAFERRO V, et al. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): A phase 3, randomised, double-blind, placebo-controlled trial[J]. Lancet Oncol, 2015, 16(13): 1344-1354. DOI: 10.1016/S1470-2045(15)00198-9.
    [21] LI M, SU Y, ZHANG F, et al. A dual-targeting reconstituted high density lipoprotein leveraging the synergy of sorafenib and antimiRNA21 for enhanced hepatocellular carcinoma therapy[J]. Acta Biomater, 2018, 75: 413-426. DOI: 10.1016/j.actbio.2018.05.049.
    [22] KUDO M, FINN RS, QIN S, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial[J]. Lancet, 2018, 391(10126): 1163-1173. DOI: 10.1016/S0140-6736(18)30207-1
    [23] KIMURA T, KATO Y, OZAWA Y, et al. Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1-6 hepatocellular carcinoma model[J]. Cancer Sci, 2018, 109(12): 3993-4002. DOI: 10.1111/cas.13806.
    [24] BRUIX J, QIN S, MERLE P, et al. Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): A randomised, double-blind, placebo-controlled, phase 3 trial[J]. Lancet, 2017, 389(10064): 56-66. DOI: 10.1016/S0140-6736(16)32453-9.
    [25] DEEKS ED. Cabozantinib: A review in advanced hepatocellular carcinoma[J]. Target Oncol, 2019, 14(1): 107-113. DOI: 10.1007/s11523-019-00622-y.
    [26] KASPRZAK A, ADAMEK A. Role of Endoglin (CD105) in the progression of hepatocellular carcinoma and anti-angiogenic therapy[J]. Int J Mol Sci, 2018, 19(12): 3887. DOI: 10.3390/ijms19123887.
    [27] LEE JH, LEE JH, LIM YS, et al. Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma[J]. Gastroenterology, 2015, 148(7): 1383-1391. e6. DOI: 10.1053/j.gastro.2015.02.055.
    [28] LIU LX, CAI W. Current situation and prospect of immunotherapy for hepatocellular carcinoma[J]. Chin J Dig Surg, 2020, 19(2): 119-122. DOI: 10.3760/ma.j.issn.1673-9752.2020.02.002.

    刘连新, 蔡伟. 肝细胞癌免疫治疗的现状和展望[J]. 中华消化外科杂志, 2020, 19(2): 119-122. DOI: 10. 3760/cma. j. issn. 1673-9752. 2020.02.002.
    [29] PINTER M, PECK-RADOSAVLJEVIC M. Review article: Systemic treatment of hepatocellular carcinoma[J]. Aliment Pharmacol Ther, 2018, 48(6): 598-609. DOI: 10.1111/apt.14913.
    [30] SANMAMED MF, CHEN L. A paradigm shift in cancer immunotherapy: From enhancement to normalization[J]. Cell, 2019, 176(3): 677. DOI: 10.1016/j.cell.2019.01.008.
    [31] WAIDMANN O. Recent developments with immunotherapy for hepatocellular carcinoma[J]. Expert Opin Biol Ther, 2018, 18(8): 905-910. DOI: 10.1080/14712598.2018.1499722.
    [32] ZHANG BH, PAN XP, COBB GP, et al. MicroRNAs as oncogenes and tumor suppressors[J]. Dev Biol, 2009, 302(1): 1-12. DOI: 10.1016/j.ydbio.2006.08.028.
    [33] TANG ZH, TANG CW, WANG SH, et al. The research situation and progress in the invasion and metastasis mechanism of intrahepatic cholangiocarcinoma[J]. Chin J Dig Surg, 2019, 18(4): 321-327. DOI: 10.3760 / cma.j.issn.1673-9752.2019.04.006.

    汤朝晖, 唐陈伟, 王寿华, 等. 肝内胆管癌侵袭转移机制的研究现状与进展[J]. 中华消化外科杂志, 2019, 18(4): 321-327. DOI: 10.3760/cma.j.issn.1673-9752.2019.04.006.
    [34] WEILER J, HUNZIKER J, HALL J. Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease?[J]. Gene Ther, 2006, 13(6): 496-502. DOI: 10.1038/sj.gt.3302654.
    [35] HU Q, WANG K, SUN X, et al. A redox-sensitive, oligopeptide-guided, self-assembling, and efficiency-enhanced (ROSE) system for functional delivery of microRNA therapeutics for treatment of hepatocellular carcinoma[J]. Biomaterials, 2016, 104: 192-200. DOI: 10.1016/j.biomaterials.2016.07.016.
    [36] LI F, WANG F, ZHU C, et al. miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker[J]. Int J Nanomedicine, 2018, 13: 2295-2307. DOI: 10.2147/IJN.S157805.
    [37] LIU X, LI M, WANG X, et al. Effects of adjuvant traditional Chinese medicine therapy on long-term survival in patients with hepatocellular carcinoma[J]. Phytomedicine, 2019, 62: 152930. DOI: 10.1016/j.phymed.2019.152930.
    [38] LI C, XU X. Biological functions and clinical applications of exosomal non-coding RNAs in hepatocellular carcinoma[J]. Cell Mol Life Sci, 2019, 76(21): 4203-4219. DOI: 10.1007/s00018-019-03215-0.
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  • 收稿日期:  2020-10-26
  • 录用日期:  2020-11-11
  • 出版日期:  2021-05-20
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