靶向共价闭合环状DNA抗HBV治疗的研究进展

王艺颖; 刘熙称; 朴荣利; 秦俊杰

doi:10.3969/j.issn.1001-5256.2021.05.044

靶向共价闭合环状DNA抗HBV治疗的研究进展

DOI: 10.3969/j.issn.1001-5256.2021.05.044

吉林大学第一医院肝病科，长春 130000

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：王艺颖负责资料分析、撰写论文；刘熙称负责收集数据，修改论文；朴荣利负责课题设计、拟定写作思路；秦俊杰负责撰写文章并最后定稿。

详细信息

作者简介:
王艺颖(1995—)，女，主要从事肝病的治疗

通信作者:
秦俊杰, qinjj.1982@163.com

中图分类号: R512.621001-5256(2021)05-1189-04
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- 被引次数: 0
出版历程
- 收稿日期: 2020-10-12
- 录用日期: 2020-11-23
- 出版日期: 2021-05-20

Research advances in anti-hepatitis B virus therapy targeting covalently closed circular DNA

Department of Hepatology, The First Hospital of Jilin University, Changchun 130000, China

摘要

摘要: HBV引起尚未治愈的慢性感染，是世界范围内的主要健康负担。共价闭合环状DNA作为稳定的微染色体存在于受感染细胞的细胞核中，当新型治疗手段实现灭活或消除感染肝细胞中持久存在的共价闭合环状DNA，慢性感染自然过程和长期抗病毒治疗将不复存在。介绍了通过基因编辑、表观遗传修饰等方法靶向共价闭合环状DNA, 以期完全性治愈HBV感染。
- 共价闭合环状DNA /
- 乙型肝炎病毒 /
- 基因编辑
Abstract: The incurable chronic infection caused by hepatitis B virus (HBV) is the major health burden worldwide. Covalently closed circular DNA (cccDNA) exists in the nucleus of infected cells as a stable minichromosome, and when a new therapy realizes inactivation or eliminates persistent cccDNA in infected hepatocytes, the natural process of chronic infection and long-term antiviral therapy will no longer exist. This article introduces the methods targeting cccDNA, such as gene editing and epigenetic modification, so as to achieve the complete cure of HBV infection.
- Covalently Closed Circular DNA /
- Hepatitis B Virus /
- Gene Editing

HTML全文

图 1 HBV复制周期示意图^{[4, 17-18]}

下载: 全尺寸图片幻灯片

表 1 新研发的抗HBV感染的代表药物

类型	药物名称	作用机理	类别	临床阶段
进入抑制剂	Myrcludex B	阻断NTCP	肽类	Ⅱ
	CRV431	阻断NTCP和蛋白质折叠	小分子	Ⅰ
翻译抑制剂	JNJ3989	mRNA降解	siRNA	Ⅱ
	GSK3389404	mRNA降解	反义寡核苷酸	Ⅱ
衣壳装配抑制剂	RO7049389	结合核心蛋白	小分子	Ⅱ
	ABI-H0731	结合核心蛋白	小分子	Ⅱ
	JNJ0440	结合核心蛋白	小分子
HBsAg分泌抑制剂	REP 2139、REP 2165	结合HBsAg	核酸基聚合物	Ⅱ
先天性免疫激活剂	Inarigivir	RIG-Ⅰ激动剂和聚合酶抑制剂	小分子	Ⅱ
适应性免疫激活剂	TG-1050	疫苗	5型腺病毒抗体	Ⅰ

下载: 导出CSV

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