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结直肠癌肝转移立体定向消融放疗
DOI: 10.3969/j.issn.1001-5256.2021.03.006
利益冲突声明：所有作者均声明不存在利益冲突。
作者贡献声明：李学敏负责调研整理文献，起草论文；王皓负责提出研究选题，修订论文；王俊杰负责终审论文，获取研究经费及指导性支持。
Stereotactic ablative radiotherapy for colorectal cancer liver metastasis
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摘要: 全身治疗和转移灶局部治疗可以改善结直肠癌肝转移(CRLM)患者的生存。体部立体定向放射治疗，又称立体定向消融放疗(SABR)，不仅是转移灶局部治疗的有效手段，还对全身免疫状态具有一定的影响。SABR可以直接杀伤肿瘤细胞，也通过对肿瘤细胞和非肿瘤细胞的影响改变肿瘤免疫微环境。SABR联合免疫治疗可能通过影响免疫应答的各个环节增加照射区域之外病灶远隔效应的发生率。立体定向近距离消融(SABT)是一种独立的微创治疗体系，具有疗程短、精确性高、疗效确切的特点。现就SABR和SABT在CRLM中的应用进行综述。Abstract: Systemic treatment and local treatment of metastatic lesion can improve the survival of patients with colorectal cancer liver metastasis (CRLM). Stereotactic body radiotherapy, also known as stereotactic ablative radiotherapy (SABR), is an effective method for local treatment of metastatic lesion and also has a certain impact on systemic immune status. SABR can directly kill tumor cells and change tumor immune microenvironment through influence on tumor cells and non-tumor cells. SABR combined with immunotherapy may increase the incidence rate of abscopal effect outside the irradiated area by affecting different links of immune response. Stereotactic ablative brachytherapy (SABT) is an independent minimally invasive treatment system with the characteristics of short treatment course, high accuracy, and definite therapeutic effect. This article reviews the application of SABR and SABT in CRLM.
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